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Condition: Polymyositis

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Total 420 results found since Jan 2013.

Lipid storage myopathy due to late-onset multiple Acyl-CoA dehydrogenase deficiency with novel mutations in ETFDH: A case report
ConclusionOur observations extend the spectrum of ETFDH variants in Chinese the population and reinforce the role of NGS in diagnosis of MADD. Early diagnosis and appropriate treatment of LSM lead to great clinical efficacy and avoid some lethal complications.
Source: Frontiers in Neurology - December 15, 2022 Category: Neurology Source Type: research

Idiopathic Inflammatory Myopathy-associated Interstitial Lung Disease (IIM-ILD): does radiologic features matter?
Conclusions: Ground-glass-opacities is the prevalent HRCT pattern and is associated to normal lung volume. Fibrotic changes are present at presentation in over a quarter of the population. Consolidation needs a special attention being associated to muscle injury and anticipating the diagnosis of IIM.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Castelli, G., Cocconcelli, E., Zanatta, E., Giraudo, C., Bernardinello, N., Dartora, C., Iaccarino, L., Spagnolo, P., Balestro, E. Tags: 12.04 - Rare ILD/DPLD Source Type: research

Assessment of idiopathic inflammatory myopathy using a deep learning method for muscle T2 mapping segmentation
ConclusionAutomatic DL could be used to segment thigh muscles and help quantitatively assess muscular inflammation of IIM through T2 mapping.Key Points•Muscle T2 mapping automatically segmented by deep learning can differentiate IIM from healthy controls.•T2 value, an indicator of active muscle inflammation, positively correlates with serum muscle enzymes.• T2 mapping can detect muscle disease in patients with normal muscle enzyme levels.
Source: European Radiology - November 18, 2022 Category: Radiology Source Type: research

In-patient comorbidities in inclusion body myositis: a United States national in-patient sample-based study
CONCLUSIONS: IBM increases a patient's risk for dysphagia, falls, and infection as compared to other IIM patients. Further population-based studies are warranted to better elucidate the impact of these comorbidities in patients with IBM.PMID:36377563 | DOI:10.55563/clinexprheumatol/791fq8
Source: Clinical and Experimental Rheumatology - November 15, 2022 Category: Rheumatology Authors: Anthony K Ma Feng Dai Bhaskar Roy Source Type: research

Identification of hub biomarkers and immune cell infiltration characteristics of polymyositis by bioinformatics analysis
ConclusionWe identified the hub genes closely related to PM using WGCNA combined with LASSO algorithm, which helped clarify the molecular mechanism of PM development and might have great significance for finding new immunotherapeutic targets, and disease prevention and treatment.
Source: Frontiers in Immunology - September 26, 2022 Category: Allergy & Immunology Source Type: research

Genetic influences in cancer ‐associated myositis
Idiopathic inflammatory myopathies comprise a heterogeneous group of rare immune-mediated disorders that primarily affect muscles, but also lead to dysfunction of other organs. Five different clinical sub-phenotypes of IIM have been distinguished: dermatomyositis, polymyositis, inclusion body myositis, anti-synthetase syndrome and immune-mediated necrotizing myopathy. Excess mortality and morbidity associated with IIM are by large attributed to comorbidities, particularly cancer. The risk of malignancy is not equally distributed among IIM groups and is particularly high among patients with dermatomyositis. The cancer risk ...
Source: Arthritis and Rheumatology - September 2, 2022 Category: Rheumatology Authors: Karina Patasova, Ingrid E Lundberg, Marie Holmqvist Tags: Review Source Type: research