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Condition: Polymyositis

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Total 420 results found since Jan 2013.

Differences in muscle magnetic resonance imaging findings between anti-signal recognition particle antibody-positive myopathy and anti-aminoacyl-tRNA synthetase antibody-positive myositis
CONCLUSIONS: A comparison of thigh MRI between anti-SRP myopathy and anti-ARS myositis showed different findings and lesion sites reflecting the different pathophysiology that may contribute to their diagnosis.PMID:37497714 | DOI:10.55563/clinexprheumatol/fjfkfs
Source: Clinical and Experimental Rheumatology - July 27, 2023 Category: Rheumatology Authors: Masatoshi Kimura Ayako Aizawa Risa Kudou Yuki Rikitake Chihiro Iwao Mao Rikitake Kousho Iwao Yumi Kariya Takeshi Kawaguchi Motohiro Matsuda Shunichi Miyauchi Ichiro Takajo Kunihiko Umekita Source Type: research

An atypical presentation of hypothyroidism with extremely exaggerated functional impairment
We report a 34-year-old woman, presenting with a new atypical musculoskeletal manifestation of hypothyroidism mimicking polymyositis.
Source: Clinical Case Reports - July 19, 2023 Category: General Medicine Authors: Alireza Arezoumand, Sahar Nazari, Kimia Jazi, Mohammad Bagherzade, Mohammad Mehdi Riahi, Melika AkbariMehr, Narges Kanganee, Maryam Masoumi Tags: CASE REPORT Source Type: research

Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis
CONCLUSIONS: Overall, our study demonstrates the mitochondrial involvement in the skeletal muscle pathology and calcinosis of JDM and mtROS as a central player in the calcification of human skeletal muscle cells. Therapeutic targeting of mtROS and/or upstream inducers, such as inflammation, may alleviate mitochondrial dysfunction, leading to calcinosis. AMAs can potentially identify patients with JDM at risk for developing calcinosis.PMID:37244073 | DOI:10.1016/j.jaut.2023.103061
Source: Journal of Autoimmunity - May 27, 2023 Category: Allergy & Immunology Authors: Bhargavi Duvvuri Lauren M Pachman Payton Hermanson Ting Wang Richard Moore Dennis Ding-Hwa Wang Aaron Long Gabrielle A Morgan Stephen Doty Rong Tian Yasemin Sancak Christian Lood Source Type: research

Molecular signature of neutrophil extracellular trap mediating disease module in idiopathic inflammatory myopathy
J Autoimmun. 2023 May 21;138:103063. doi: 10.1016/j.jaut.2023.103063. Online ahead of print.ABSTRACTThe rarity and heterogeneity of idiopathic inflammatory myopathy (IIM) pose challenges for researching IIM in affected individuals. We analyzed integrated transcriptomic datasets obtained using muscle tissues from patients with five distinct IIM subtypes to investigate the shared and distinctive cellular and molecular characteristics. A transcriptomic dataset of muscle tissues from normal controls (n = 105) and patients with dermatomyositis (n = 89), polymyositis (n = 33), inclusion body myositis (n = 121), immune-mediated n...
Source: Journal of Autoimmunity - May 23, 2023 Category: Allergy & Immunology Authors: Su-Jin Moon Seung Min Jung In-Woon Baek Kyung-Su Park Ki-Jo Kim Source Type: research

Metabolic profiling of patients with different idiopathic inflammatory myopathy subtypes reveals potential biomarkers in plasma
AbstractIdiopathic inflammatory myopathy (IIM) are heterogeneous autoimmune diseases that primarily affect the proximal muscles. IIM subtypes include dermatomyositis (DM), polymyositis (PM), and anti-synthetase syndrome (ASS). Metabolic disturbances may cause irreversible structural damage to muscle fibers in patients with IIM. However, the metabolite profile of patients with different IIM subtypes remains elusive. To investigate metabolic alterations and identify patients with different IIM subtypes, we comprehensively profiled plasma metabolomics of 46 DM, 13 PM, 12 ASS patients, and 30 healthy controls (HCs) using UHPLC...
Source: Clinical and Experimental Medicine - April 27, 2023 Category: Research Source Type: research

Bibliometric and altmetric analyses of publication activity in the field of idiopathic inflammatory myopathy in 2011 –2021 based on web of science core collection databases
AbstractIdiopathic inflammatory myopathy is a multisystem autoimmune condition characterized by muscle inflammation (myositis) and interstitial lung disease (ILD). Bibliometric analysis and altmetric analysis are effective methods of evaluating academic productivity and measuring the influence of publications. The purpose of this study is to analyze the research productivity and influence of idiopathic inflammatory myopathy articles using bibliometric analysis and altmetric analysis. Data from articles published between 2011 and 2021 were obtained from the Web of Science. Altmetric attention scores and Mendeley reader coun...
Source: Rheumatology International - April 25, 2023 Category: Rheumatology Source Type: research

Rituximab as the first-line therapy in anti-synthetase syndrome-related interstitial lung disease
AbstractAnti-synthetase syndrome (ASS) is an idiopathic inflammatory myopathy (IIM). In comparison to interstitial lung disease (ILD) in polymyositis and dermatomyositis (PM/DM), ILD in ASS is more frequent, has a more aggressive phenotype, a greater involvement of the lungs, and a more rapid onset of pulmonary symptoms. Continuous declines in predicted forced vital capacity (FVC) and dyspnea were the main features of patients who developed end-stage ILD. The severity of ASS at diagnosis dictates when and which immunosuppressant will be started. There is an experience for the usage of RTX in the first, second, and subseque...
Source: Rheumatology International - April 25, 2023 Category: Rheumatology Source Type: research

Bibliometric and altmetric analyses of publication activity in the field of idiopathic inflammatory myopathy in 2011 –2021 based on web of science core collection databases
AbstractIdiopathic inflammatory myopathy is a multisystem autoimmune condition characterized by muscle inflammation (myositis) and interstitial lung disease (ILD). Bibliometric analysis and altmetric analysis are effective methods of evaluating academic productivity and measuring the influence of publications. The purpose of this study is to analyze the research productivity and influence of idiopathic inflammatory myopathy articles using bibliometric analysis and altmetric analysis. Data from articles published between 2011 and 2021 were obtained from the Web of Science. Altmetric attention scores and Mendeley reader coun...
Source: Rheumatology International - April 24, 2023 Category: Rheumatology Source Type: research

Clinical significance of anti-NT5c1A autoantibody in Korean patients with inflammatory myopathies
by Seung-Ah Lee, Hyun Joon Lee, Bum Chun Suh, Ha Young Shin, Seung Woo Kim, Byeol-A Yoon, Young-Chul Choi, Hyung Jun Park To explore the clinical significance of anti-cytosolic 5’-nucleoditase 1A (NT5c1A) antibody seropositivity in inflammatory myopathies, we measured anti-NT5c1A antibodies and analyzed their clinical features. Anti-NT5c1A antibodies were measured in the sera of 103 patients with inflammatory myopa thies using an enzyme-linked immunosorbent assay. Positivity for anti-NT5c1A antibody was found in 13 (12.6%) of 103 patients with inflammatory myopathy. Anti-NT5c1A antibody was most frequently identified in...
Source: PLoS One - April 14, 2023 Category: Biomedical Science Authors: Seung-Ah Lee Source Type: research

Pneumomediastinum, pneumatosis intestinalis and pneumoperitoneum in a patient with polymyositis: case-based review
We present a 59-year-old polymyositis (PM) patient who experienced all three complications simultaneously. The patient who presented with proximal muscle weakness, dysphagia, and weight loss was diagnosed with PM due to elevated muscle enzymes and consistent electromyography and muscle biopsy with inflammatory myopathy. On the 45th day of her immunosuppressive treatment, PnM, PI, and PP were detected incidentally in18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) scan performed for severe weight loss and treatment-resistant severe disease. Since the patient had no symptoms or signs o...
Source: Rheumatology International - March 12, 2023 Category: Rheumatology Source Type: research

Correspondence on 'EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups
The publication of the European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) 2017 classification criteria for adult and juvenile idiopathic inflammatory myopathy is a landmark with 186 citations as of date.1 Patients with dermatomyositis (DM) and polymyositis (PM) differ with respect to clinical features, autoantibody profile and treatment response and have been subgrouped for a long time now.2 We studied 26 consecutive adult patients over 1 year seen in a tertiary teaching hospital in south India, satisfying either the 2017 criteria or 1975 Bohan-Peter criteria for idiopathic inflammatory myositi...
Source: Annals of the Rheumatic Diseases - January 23, 2023 Category: Rheumatology Authors: Mohammad, I., Devarasetti, P. K., Rajasekhar, L. Tags: ARD Correspondence Source Type: research

Coexisting autoantibodies against transcription factor Sp4 are associated with decreased cancer risk in patients with dermatomyositis with anti-TIF1{gamma} autoantibodies
Conclusions Anti-Sp4 autoantibodies appear to identify a subgroup of anti-TIF1-positive DM patients with lower cancer risk.
Source: Annals of the Rheumatic Diseases - January 23, 2023 Category: Rheumatology Authors: Hosono, Y., Sie, B., Pinal-Fernandez, I., Pak, K., Mecoli, C. A., Casal-Dominguez, M., Warner, B. M., Kaplan, M. J., Albayda, J., Danoff, S., Lloyd, T. E., Paik, J. J., Tiniakou, E., Aggarwal, R., Oddis, C. V., Moghadam-Kia, S., Carmona-Rivera, C., Milise Tags: ARD, Myositis Source Type: research