Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis

CONCLUSIONS: Overall, our study demonstrates the mitochondrial involvement in the skeletal muscle pathology and calcinosis of JDM and mtROS as a central player in the calcification of human skeletal muscle cells. Therapeutic targeting of mtROS and/or upstream inducers, such as inflammation, may alleviate mitochondrial dysfunction, leading to calcinosis. AMAs can potentially identify patients with JDM at risk for developing calcinosis.PMID:37244073 | DOI:10.1016/j.jaut.2023.103061

Source: Journal of Autoimmunity - May 27, 2023 Category: Allergy & Immunology Authors: Bhargavi Duvvuri Lauren M Pachman Payton Hermanson Ting Wang Richard Moore Dennis Ding-Hwa Wang Aaron Long Gabrielle A Morgan Stephen Doty Rong Tian Yasemin Sancak Christian Lood Source Type: research