Idiopathic inflammatory myopathies – increased expression of heat shock protein-90 in muscle tissue and plasma correlates with disease activity and skeletal muscle involvement

Heat shock proteins (Hsp) are chaperones playing important roles in skeletal muscle physiology, adaptation to exercise or stress, and activation of inflammatory cells. The aim of our study was to assess Hsp90 expression in muscle biopsies and plasma of patients with idiopathic inflammatory myopathies (IIM) and to characterize its association with IIM-related features. Total of 277 patients with IIM (dermatomyositis (DM, 104); polymyositis (PM, 104); cancer associated myositis (CAM, 42); necrotizing myopathy (IMNM, 27)), and 100 age-/sex-matched healthy individuals were included in Hsp90 plasma analysis by ELISA.

Source: Neuromuscular Disorders - September 10, 2017 Category: Neurology Authors: J. Zamecnik, H. Storkanova, O. Krystufkova, M. Klein, H. Mann, L. Vernerova, M. Spiritovic, L. Senolt, J. Vencovsky, M. Tomcik Source Type: research