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Identification of specific markers for amphetamine synthesised from the pre ‐precursor APAAN following the Leuckart route and retrospective search for APAAN markers in profiling databases from Germany and the Netherlands
In this study several syntheses of amphetamine following the Leuckart route were performed starting from different organic compounds including APAAN. The organic phases were analysed using GC/MS to search for signals caused by possible APAAN markers. Three compounds were discovered, isolated and based on the performed syntheses it was found that they are highly specific for the use of APAAN. Using mass spectra, high resolution MS and NMR data the compounds were characterised and identified as 2‐phenyl‐2‐butenenitrile, 3‐amino‐2‐phenyl‐2‐butenenitrile and 4‐amino‐6‐methyl‐5‐phenylpyrimidine. To inv...
Source: Drug Testing and Analysis - August 1, 2017 Category: Drugs & Pharmacology Authors: Frank M. Hauser, Thorsten R ößler, Janneke W. Hulshof, Diana Weigel, Ralf Zimmermann, Michael Pütz Tags: RESEARCH ARTICLE Source Type: research
The Search for Anticancer Agents from Tropical Plants.
Authors: Henkin JM, Ren Y, Soejarto DD, Kinghorn AD
Abstract
Many of the clinically used anticancer agents in Western medicine are derived from secondary metabolites found in terrestrial microbes, marine organisms, and higher plants, with additional compounds of this type being currently in clinical trials. If plants are taken specifically, it is generally agreed that the prospects of encountering enhanced small organic-molecule chemical diversity are better if tropical rather than temperate species are investigated in drug discovery efforts. Plant collection in tropical source countries requires considerable prepa...
Source: Progress in the chemistry of organic natural products - September 6, 2018 Category: Chemistry Tags: Prog Chem Org Nat Prod Source Type: research
Author Correction: Controlling an organic synthesis robot with machine learning to search for new reactivity
Nature, Published online: 26 June 2019; doi:10.1038/s41586-019-1218-zAuthor Correction: Controlling an organic synthesis robot with machine learning to search for new reactivity
Source: Nature AOP - June 25, 2019 Category: Research Authors: Jaros ław M. Granda Liva Donina Vincenza Dragone De-Liang Long Leroy Cronin Source Type: research
Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search.
Abstract
Optimization of export mechanisms for valuable extracellular products is important for the development of efficient microbial production processes. Identification of the relevant export mechanism is the prerequisite step for product export optimization. In this work, we identified transporters involved in malate export in an engineered L-malate-producing Escherichia coli strain using cheminformatics-guided genetics tests. Among all short-chain di- or tricarboxylates with known transporters in E. coli, citrate, tartrate, and succinate are most chemically similar to malate as estimated by their molecular si...
Source: Applied Microbiology and Biotechnology - October 21, 2019 Category: Microbiology Authors: Kurgan G, Kurgan L, Schneider A, Onyeabor M, Rodriguez-Sanchez Y, Taylor E, Martinez R, Carbonell P, Shi X, Gu H, Wang X Tags: Appl Microbiol Biotechnol Source Type: research
Source-related smart suspect screening in the aqueous environment: search for tire-derived persistent and mobile trace organic contaminants in surface waters.
Abstract
A variant of suspect screening by liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is proposed in this study: Samples of a potential source of contamination and of an environmental sample close to this source are first analyzed in a non-targeted manner to select source-related suspects and to identify them. The suspect list compiled from such an exercise is then applied to LC-HRMS data of environmental samples to ascribe and to identify persistent and mobile contaminants in the water cycle that may originate from the source under study. This approach was applied to tire crumb rubber (sour...
Source: Analytical and Bioanalytical Chemistry - May 7, 2020 Category: Chemistry Authors: Seiwert B, Klöckner P, Wagner S, Reemtsma T Tags: Anal Bioanal Chem Source Type: research
New substance library to accelerate the search for active compounds
(Helmholtz-Zentrum Berlin f ü r Materialien und Energie) The MX team at HZB and a Group at the University of Marburg have established a new substance library. It consists of 1103 organic molecules that could be used as building blocks for new drugs. Now, this library has been validated at MAX IV. The substance library of the HZB is available for research worldwide and also plays a role in the search for active substances against SARS-CoV-19.
Source: EurekAlert! - Medicine and Health - July 13, 2020 Category: International Medicine & Public Health Source Type: news
Molecules, Vol. 26, Pages 3288: In Search of Factors Determining Activity of Co3O4 Nanoparticles Dispersed in Partially Exfoliated Montmorillonite Structure
owski
The paper discusses a formation of Mt–PAA composite containing a natural montmorillonite structure partially exfoliated by poly(acrylic acid) introduced through intercalation polymerization of acrylic acid. Mt–PAA was subsequently modified by controlled adsorption of Co2+ ions. The presence of aluminosilicate packets (clay) and carboxyl groups (hydrogel) led to the deposition of significant amounts of Co2+ ions, which after calcination formed the Co3O4 spinel particles. The conditions of the Co2+ ions’ deposition (pH, volume and concentration of Co(NO3)2 solution, as well as a type of pH-controlling agent) ...
Source: Molecules - May 29, 2021 Category: Chemistry Authors: Anna Rokici ńska Tomasz Berniak Marek Drozdek Piotr Ku śtrowski Tags: Article Source Type: research
Types and harms of medical errors in urology: results of reviews from 1999-2019
CONCLUSION: Based on a systematic analysis of medical reviews over two decades, a summary is provided regarding types of diseases and procedures that are particularly prone to error in urology, the types of errors in the treatment process that give rise to direct and indirect medical error, and the that consequences have to be drawn.PMID:34086066 | DOI:10.1007/s00120-021-01516-6
Source: Der Urologe. Ausg. A - June 4, 2021 Category: Urology & Nephrology Authors: V Lent Source Type: research
Interactions of fungal phospholipase Lecitase ultra with phospholipid Langmuir monolayers - Search for substrate specificity and structural factors affecting the activity of the enzyme
Biochim Biophys Acta Biomembr. 2021 Jun 24:183687. doi: 10.1016/j.bbamem.2021.183687. Online ahead of print.ABSTRACTInoculation of selected microbial species into the soils is one of the most effective means of bioremediation of soils polluted by persistent organic pollutants as well as of biocontrol of plant pests. However, this procedure turns out frequently to be ineffective due to the membrane-destructive enzymes secreted to the soil by the autochthonous microorganisms. Especial role play here phospholipases and among them phospholipase A1 (PLA1), Therefore, to explain the interactions of microbial membranes and PLA1 a...
Source: Biochimica et Biophysica Acta - June 27, 2021 Category: Biochemistry Authors: Paulina Perczyk Roksana Gawlak Marcin Broniatowski Source Type: research
The Plight of Haiti
By Jan LundiusSTOCKHOLM / ROME, Sep 30 2021 (IPS) I assume channel surfing and internet browsing contribute to a decrease in people’s attention span. I am not familiar with any scientific proof, though while working as a teacher I found that some students may be exhausted when five minutes of a lesson has passed and begin fingering on their smartphones. They might also complain if a text is longer than half a page, while finding it almost impossible to read a book.
Maybe we are all incapable of keeping a focus. For a while, Afghanistan overshadowed the media stream, though interest faded when the tragic scenes at the ai...
Source: IPS Inter Press Service - Health - September 30, 2021 Category: International Medicine & Public Health Authors: Jan Lundius Tags: Aid Armed Conflicts Climate Change Crime & Justice Economy & Trade Education Food and Agriculture Headlines Health Human Rights Humanitarian Emergencies Labour Latin America & the Caribbean Migration & Refugees TerraViva United Source Type: news
Toxicological transcriptome of human airway constructs after exposure to indoor air particulate matter: In search of relevant pathways of moisture damage-associated health effects
DISCUSSION: The exposure to PM from index houses activated toxicology -related genes in airway constructs. Differential expression was not consistent among all the index/reference pairs, possibly due to compositional differences of bioactive particles. Our study highlights CYP1A1 and NFKB1 as potential targets in moisture damage -associated cellular responses.PMID:34991257 | DOI:10.1016/j.envint.2021.106997
Source: Environment International - January 7, 2022 Category: Environmental Health Authors: Maria-Elisa Nordberg Martin T äubel Sami Heikkinen Kaisa Jalkanen Arto K öliö Marianne Stranger Hanna Lepp änen Anne Hyv ärinen Kati Huttunen Source Type: research
Novel applications of ultrasonic atomization in the manufacturing of fine chemicals, pharmaceuticals, and medical devices
Ultrason Sonochem. 2022 Mar 17;86:105984. doi: 10.1016/j.ultsonch.2022.105984. Online ahead of print.ABSTRACTLiquid atomization as a fluid disintegration method has been used in many industrial applications such as spray drying, coating, incineration, preparation of emulsions, medical devices, etc. The usage of ultrasonic energy for atomizing liquid is gaining interest as a green and energy-efficient alternative to traditional mechanical atomizers. In the past two decades, efforts have been made to explore new applications of ultrasonic misting for downstream separation of chemicals, e.g., bioethanol, from their aqueous so...
Source: Ultrasonics Sonochemistry - April 8, 2022 Category: Chemistry Authors: Haripriya Naidu Ozan Kahraman Hao Feng Source Type: research
High-performance nontarget analysis of halogenated organic compounds in tap water, fly ash, soil and sediment using ultrahigh resolution mass spectrometry and scripting approaches based on Cl/Br-specific search algorithms
This study developed a nontarget analysis method for characterization of known and unknown HOCs in tap water, fly ash, soil and sediment using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) with aid of scripting data-processing approaches. The FT-ICR-MS was equipped with an electrospray ionization source operated in negative ion mode, and full scan at a mass resolution around 200,000 was applied. Data screening scripts were developed based on exact mass differences and abundance ratios between neighboring chlorine/bromine isotopologues. Cosine similarity analysis was applied to evaluating similarit...
Source: Analytica Chimica Acta - April 10, 2022 Category: Chemistry Authors: Caiming Tang Guangshi Chen Bin Jiang Jianhua Tan Yutao Liang Hui Lin Yanhong Zeng Xiaojun Luo Bixian Mai Xianzhi Peng Source Type: research
Novel applications of ultrasonic atomization in the manufacturing of fine chemicals, pharmaceuticals, and medical devices
Ultrason Sonochem. 2022 Mar 17;86:105984. doi: 10.1016/j.ultsonch.2022.105984. Online ahead of print.ABSTRACTLiquid atomization as a fluid disintegration method has been used in many industrial applications such as spray drying, coating, incineration, preparation of emulsions, medical devices, etc. The usage of ultrasonic energy for atomizing liquid is gaining interest as a green and energy-efficient alternative to traditional mechanical atomizers. In the past two decades, efforts have been made to explore new applications of ultrasonic misting for downstream separation of chemicals, e.g., bioethanol, from their aqueous so...
Source: Ultrasonics Sonochemistry - April 8, 2022 Category: Chemistry Authors: Haripriya Naidu Ozan Kahraman Hao Feng Source Type: research
