Progress in the chemistry of organic natural products 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Neurotrophic Natural Products
Prog Chem Org Nat Prod. 2024;123:1-473. doi: 10.1007/978-3-031-42422-9_1.ABSTRACTNeurotrophins (NGF, BDNF, NT3, NT4) can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons, which make them promising therapeutic agents for the treatment of neurodegenerative disorders. However, neurotrophins have not been very effective in clinical trials mostly because they cannot pass through the blood-brain barrier owing to being high-molecular-weight proteins. Thus, neurotrophin-mimic small molecules, which stimulate the synthesis of endogenous neurotrophins or enhance neurotrophic actio...
Source: Progress in the chemistry of organic natural products - February 10, 2024 Category: Chemistry Authors: Yoshiyasu Fukuyama Miwa Kubo Kenichi Harada Source Type: research
