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M406 what came first the immunodeficiency or immunosuppression
64 year old male with polymyositis previously treated with rituximab 5 years prior presented with hypogammaglobulinemia. Polymyositis was poorly controlled and the patient needed clearance prior to restarting rituximab. The patient had no significant infection history. Screening laboratories included a low IgG of 610, low IgM of 31 and protection to 4/14 post vaccination pneumococcal titers.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: M. Karasov, J. Carlson Source Type: research

Survey: Many U.S. Adults Not Planning to Get Flu Vaccine
Vaccine knowledge and anticipated rates of vaccination even lower for pneumococcal disease
Source: The Doctors Lounge - Oncology - October 4, 2019 Category: Cancer & Oncology Tags: Cardiology, Endocrinology, Family Medicine, Geriatrics, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nursing, Oncology, Pathology, Pediatrics, Pharmacy, Pulmonology, Rheumatology, Institutional, Source Type: news

Otitis Media: Rapid Evidence Review.
Abstract Acute otitis media (AOM) is the most common diagnosis in childhood acute sick visits. By three years of age, 50% to 85% of children will have at least one episode of AOM. Symptoms may include ear pain (rubbing, tugging, or holding the ear may be a sign of pain), fever, irritability, otorrhea, anorexia, and sometimes vomiting or lethargy. AOM is diagnosed in symptomatic children with moderate to severe bulging of the tympanic membrane or new-onset otorrhea not caused by acute otitis externa, and in children with mild bulging and either recent-onset ear pain (less than 48 hours) or intense erythema of the t...
Source: American Family Physician - September 14, 2019 Category: Primary Care Authors: Gaddey HL, Wright MT, Nelson TN Tags: Am Fam Physician Source Type: research

A Critical View of Specific Antibody Deficiencies
Ricardo U. Sorensen1,2,3* 1Professor Emeritus of Pediatrics, Department of Pediatrics, Louisiana State University Health Science Center, New Orleans, LA, United States 2Louisiana Primary Immunodeficiency Network, New Orleans, LA, United States 3Honorary Professor, Faculty of Medicine, University of La Frontera, Temuco, Chile In thisopinion manuscript the author postulates that the present definition of Specific Antibody Deficiency (SAD) needs to be revised and expanded. It is presently defined as a syndrome of low IgG antibody responses to purified Streptococcus pneumoniae capsular polysaccharides vaccine...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for TP53 Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia
Discussion This case demonstrates successful cure of pre-B-ALL complicating XLA by alloSCT with restoration of B-cell development and functional antibody response. We are aware of only one previous case of pre-B-ALL in an XLA patient (21), which suggests that human BTK deficiency in itself does not predispose to pre-B-ALL. However, there are data to suggest that BTK may act as a tumor suppressor, and BTK deficiency may predispose to tumor development following a “second hit.” Mice with a genetic deficiency in Slp65, a gene encoding an adaptor protein that functions together with BTK, have a block in proge...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology
Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. Introduction Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influen...
Source: Frontiers in cellular and infection microbiology - April 16, 2019 Category: Microbiology Source Type: research

Keeping Athletes Healthy at the 2020 Tokyo Summer Games: Considerations and Illness Prevention Strategies
Conclusion It is apparent that athletes will be exposed to various stressors during both the preparatory and competition phases of the Summer Games. Athletes residing in the southern hemisphere appear to be at increased risk for illness during the preparatory phase, while female, Paralympic, water-sport and multi-competition/event athletes may be more susceptible to illness during the competition phase of the Summer Games. To maintain athlete health, illness prevention strategies should be targeted to stressors and at-risk athletes. Keeping athletes healthy will contribute to optimal Olympic and Paralympic athletic perfor...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome
This study was carried out after written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Stanford University and UCLA Institutional Review Boards. Author Contributions MB provided patient care and obtained IRB approval. RO prepared histology images. MB, TT, and RB designed the research. TT and LP conducted experiments and analyzed data. MB made the molecular model. MB and TT wrote the manuscript. Funding Funding for this work came from the Jeffrey Modell Foundation and from the NIH/NIGMS (R01 GM110482 to MB)....
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children
Nicolaas G. van der Maas, Dagmar Berghuis, Mirjam van der Burg and Arjan C. Lankester* Willem-Alexander Children's Hospital, Department of Pediatrics and Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, Netherlands B cell reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and influenced by different patient, donor, and treatment related factors. In this review we describe B cell reconstitution after pediatric allogeneic HST, including the kinetics of reconstitution of the different B cell subsets and the development of the B cell repertoire, and d...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Interpretation of post–pneumococcal vaccine antibody levels: Concerns and pitfalls
Publication date: March 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 3Author(s): Caitlin M.G. McNulty, James T. Li
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 4, 2019 Category: Allergy & Immunology Source Type: research

Expecting the Unexpected: Complement screening in the meningococcal vaccination era
Publication date: Available online 20 February 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Priscilla H. Wong, Rachel U. Lee
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 21, 2019 Category: Allergy & Immunology Source Type: research

Severe Necrotic Reaction to 23-Valent Polysaccharide Pneumococcal Vaccine in a Patient With STAT3 Deficiency
Publication date: Available online 15 February 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Mervin Piñones, Cecilia Vizcaya, Guillermo Pérez-Mateluna, Rodrigo Hoyos-Bachiloglu, Arturo Borzutzky
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 16, 2019 Category: Allergy & Immunology Source Type: research

Every Breath You Take – Improving Asthma Wellness
Good control of asthma reduces related deaths and costs. The CDC recommends pneumococcal vaccination for patients with asthma, aged 18-64 years. Guidelines recommend assessment and documentation of asthma severity at each clinic visit. Objectives were to determine whether specific interventions would improve rates of pneumococcal vaccination and asthma severity documentation in asthma patients.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Aparna S. Daley Source Type: research

Predicting Patient Response To Pneumococcal 23-vaccine (PPV23) Using Age, Baseline Immunoglobulins, and Pneumococcal Serotypes
The pneumococcal polysaccharide 23-serotype vaccine (PPV23) is an integral part of the evaluation and diagnosis of humoral antibody deficiencies. Although there are guidelines on how to interpret overall vaccine responses, there is a paucity of evidence on the significance of individual serotypes as possible predictors of immunodeficiency or future risk of immunodeficiency.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Rayna J. Doll, David McGarry, Nancy Joseph, Jack Jeskey, Linda Quinn, Devi Jhaveri, Haig Tcheurekdjian, Robert W. Hostoffer Source Type: research

Effect of pneumococcal conjugate vaccine introduction on childhood pneumonia mortality in Brazil: a retrospective observational study
Publication date: February 2019Source: The Lancet Global Health, Volume 7, Issue 2Author(s): Cynthia Schuck-Paim, Robert J Taylor, Wladimir J Alonso, Daniel M Weinberger, Lone SimonsenSummaryBackgroundUnderstanding the real-world effect of pneumococcal conjugate vaccines (PCVs) on pneumonia mortality is crucial because of the expectation that increased PCV use will substantially reduce the burden of pneumonia deaths in children younger than 5 years. However, few post-vaccine introduction studies have estimated the benefits of PCV use on childhood mortality and results have been inconsistent. Therefore, we set out to assess...
Source: The Lancet Global Health - January 24, 2019 Category: International Medicine & Public Health Source Type: research

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