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Vaccination: Meningitis Vaccine
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Total 126 results found since Jan 2013.
2016 Adult Immunization Schedule Includes New Vaccines2016 Adult Immunization Schedule Includes New Vaccines
New vaccines against meningococcal serogroup B and human papillomavirus and a revision to the pneumococcal vaccine recommendation are among the 2016 changes. Medscape Medical News
Source: Medscape Allergy Headlines - February 1, 2016 Category: Allergy & Immunology Tags: Internal Medicine News Alert Source Type: news
No long-term evidence of hyporesponsiveness after use of pneumococcal conjugate vaccine in children previously immunized with pneumococcal polysaccharide vaccine
A randomized controlled trial in Fiji examined the immunogenicity and effect on nasopharyngeal carriage after 0, 1, 2, or 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7; Prevnar) in infancy followed by 23-valent pneumococcal polysaccharide vaccine (23vPPV; Pneumovax) at 12 months of age. At 18 months of age, children given 23vPPV exhibited immune hyporesponsiveness to a micro-23vPPV (20%) challenge dose in terms of serotype-specific IgG and opsonophagocytosis, while 23vPPV had no effect on vaccine-type carriage.
Source: Journal of Allergy and Clinical Immunology - January 26, 2016 Category: Allergy & Immunology Authors: Paul V. Licciardi, Zheng Quan Toh, Elizabeth A. Clutterbuck, Anne Balloch, Rachel A. Marimla, Leena Tikkanen, Karen E. Lamb, Kathryn J. Bright, Uraia Rabuatoka, Lisi Tikoduadua, Laura K. Boelsen, Eileen M. Dunne, Catherine Satzke, Yin Bun Cheung, Andrew J Source Type: research
Encephalitis in Australian children: contemporary trends in hospitalisation
Conclusion
Hospitalisation of childhood encephalitis has slightly decreased in Australia. High rates of childhood immunisation have been associated with a reduction of varicella-associated encephalitis in Australian children. ADEM, an immune-mediated encephalitis, is the most common recognised cause of encephalitis in children. Young children (<1 year) have the highest admission rates. The high proportion of ‘unspecified’ encephalitis deaths and hospitalisations is an ongoing challenge.
Source: Archives of Disease in Childhood - December 14, 2015 Category: Pediatrics Authors: Britton, P. N., Khoury, L., Booy, R., Wood, N., Jones, C. A. Tags: Health policy, Immunology (including allergy), Meningitis, Vaccination / immunisation, Infection (neurology), Health economics, Health service research Original article Source Type: research
Question 1: Does prophylactic paracetamol prevent fever after vaccination in infants?
Scenario A 2-month-old infant is brought into the emergency department with a 24 h history of fever. He was born at term and had an uneventful neonatal period with no risk factors for sepsis. Clinical examination was unremarkable apart from a temperature of 38.5°C. Upon further questioning, his mother revealed that the infant had received his routine vaccinations the previous day. She had been advised to give prophylactic paracetamol at the time of vaccination but had refrained from doing so because, 2 years previously, the same practice nurse had told her to give paracetamol to her older child only if he dev...
Source: Archives of Disease in Childhood - November 19, 2015 Category: Pediatrics Authors: Braccio, S., Saliba, V., Ramsay, M., Ladhani, S. N. Tags: ADC Archimedes, Liver disease, Clinical trials (epidemiology), Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, Hepatitis and other GI infections, Meningitis, TB and other respiratory infections, Tropical medicine (infect Source Type: research
The RTS,S/AS01 vaccine continues to show modest protection against malaria in African infants and children
This report provides final follow-up data for a large phase III trial conducted at 11 sites in sub-Saharan Africa. It...
Source: Evidence-Based Medicine - September 24, 2015 Category: Internal Medicine Authors: Rosenthal, P. J. Tags: Clinical trials (epidemiology), Immunology (including allergy), Meningitis, Travel medicine, Tropical medicine (infectious diseases), Vaccination / immunisation, Infection (neurology) Therapeutics/Prevention Source Type: research
Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections.
Abstract
We characterized 121 adults with frequent or severe bacterial respiratory tract infections at diagnosis of selective subnormal IgG3. Mean age was 47±13 (SD)y; 87.6% were women. Associated disorders included: autoimmune conditions 33.1%; hypothyroidism 14.9%; atopy 29.8%; and other allergy manifestations 41.3%. In 34.1%, proportions of protective Streptococcus pneumoniae serotype-specific IgG levels did not increase after polyvalent pneumococcal polysaccharide vaccination. Blood CD19+, CD3+/CD4+, CD3+/CD8+, and CD56+/CD16+ lymphocyte levels were within reference limits in most patients. In regression anal...
Source: Cellular Immunology - September 14, 2015 Category: Allergy & Immunology Authors: Barton JC, Bertoli LF, Barton JC, Acton RT Tags: Cell Immunol Source Type: research
Specific Antibody Deficiencies
Patients with specific antibody deficiency (SAD) have a deficient immunologic response to polysaccharide antigens. Such patients experience sinopulmonary infections with increased frequency, duration, or severity compared with the general population. SAD is definitively diagnosed by immunologic challenge with a pure polysaccharide vaccine in patients 2 years old and older who have otherwise intact immunity, using the 23-valent pneumococcal polysaccharide vaccine as the current gold standard. Specific antibody deficiencies comprise multiple immunologic phenotypes. Treatment must be tailored based on the severity of symptom...
Source: Immunology and Allergy Clinics of North America - August 25, 2015 Category: Allergy & Immunology Authors: Luke A. Wall, Victoria R. Dimitriades, Ricardo U. Sorensen Source Type: research
Decreased IgM, IgA, and IgG response to pneumococcal vaccine in children with transient hypogammaglobulinemia of infancy
Transient hypogammaglobulinemia of infancy (THI) is a primary antibody deficiency occurring in the first years of life and is characterized by a delay in the immunoglobulin production that spontaneously recovers in early infancy. In the young symptomatic child with low IgG levels and more than 2% B cells, there are no peculiar clinical and immunologic features that allow discrimination between self-limiting THI, common variable immunodeficiency, or other dysgammaglobulinemias. Only those patients whose IgG levels have normalized after age 4 years have a definitive THI diagnosis made a posteriori.
Source: Journal of Allergy and Clinical Immunology - July 30, 2015 Category: Allergy & Immunology Authors: Viviana Moschese, Filomena Monica Cavaliere, Simona Graziani, Caterina Bilotta, Cinzia Milito, Loredana Chini, Isabella Quinti Tags: Letter to the Editor Source Type: research
ACIP backs broader use of MenB vaccination to include adolescents and college students
A recommendation to expand serogroup B meningococcal vaccination to include adolescents and young adults, including college students, was supported by the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices, at a <a...
Source: Skin and Allergy News - June 24, 2015 Category: Dermatology Tags: CNN News CNN Pediatric Neurology EM Clinical News EM News EM Infectious Disease FPN News FPN Child & Adolescent Medicine FPN Infectious Diseases Source Type: news
Using root cause analysis (rca) to ensure learning from an error involving the national infant primary immunisation schedule
Conclusion
Using RCA methodology to investigate this error identified several deficiencies in the process for immunisation within our Trust enabling action to be taken to ensure that the process is more robust in the future. This has included changing pharmacy purchasing processes for immunisations, identifying both a lead pharmacist and clinician for immunisations, improving links with primary care and PHE and starting to develop minimum standards for immunisations within the Trust. Involving PHE in the RCA process also facilitated learning on a national basis.
Source: Archives of Disease in Childhood - May 18, 2015 Category: Pediatrics Authors: Aindow, A., Gill, A., Sharpe, D., Barker, C., Mulvoy, J., Falconer, M., Riordan, A. Tags: Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Child health, Infant health Short Papers Source Type: research
Vaccine evaluation: lessons from a meningococcal B vaccine
Vaccination is among the most effective public health interventions of the past century, with immunisations against some of the most common and devastating childhood infections already in use to great effect. The development of new vaccines depends on advances in the field of vaccinology that carry high monetary costs. In most countries, these costs pose an obstacle to adoption of new vaccines. To that end, together with the scientific evaluation of new vaccines, an economic evaluation is vital. This aims to determine whether investment in the proposed vaccine is worthwhile. In this article, we will examine one such case s...
Source: Archives of Disease in Childhood - May 18, 2015 Category: Pediatrics Authors: Sarfatti, A., Martinon-Torres, F., Nadel, S. Tags: Patients, Health policy, Vaccination programs, Immunology (including allergy), Drugs: infectious diseases, Meningitis, Vaccination / immunisation, Infection (neurology), Neonatal and paediatric intensive care, Paediatric intensive care, Health economics, Source Type: research
Humoral immune response to vaccines in patients with rheumatoid arthritis treated with tocilizumab: results of a randomised controlled trial (VISARA)
Conclusions
Short-term TCZ treatment does not significantly attenuate humoral responses to PPV23 or TTV. To maximise vaccine response, patients should be up to date with immunisations before starting TCZ treatment.
ClinicalTrials.gov identifier
NCT01163747.
Source: Annals of the Rheumatic Diseases - April 2, 2015 Category: Rheumatology Authors: Bingham, C. O., Rizzo, W., Kivitz, A., Hassanali, A., Upmanyu, R., Klearman, M. Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research
Has the incidence of empyema in Scottish children continued to increase beyond 2005?
Conclusions
The incidence of empyema in Scottish children initially rose in children aged 1 to 9 years after the introduction of routine conjugate pneumococcal vaccination, however, empyema incidence has fallen since 2010 when the PCV-13 was introduced.
Source: Archives of Disease in Childhood - February 18, 2015 Category: Pediatrics Authors: Nath, S., Thomas, M., Spencer, D., Turner, S. Tags: Immunology (including allergy), Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Vaccination / immunisation, Pneumonia (respiratory medicine), Ear, nose and throat/otolaryngology Original article Source Type: research
Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk Indigenous infants (PREV-IX_COMBO): protocol of a randomised controlled trial
Introduction
Otitis media (OM) starts within weeks of birth in almost all Indigenous infants living in remote areas of the Northern Territory (NT). OM and associated hearing loss persist from infancy throughout childhood and often into adulthood. Educational and social opportunities are greatly compromised. Pneumococcus and non-typeable Haemophilus influenzae (NTHi) are major OM pathogens that densely colonise the nasopharynx and infect the middle ear from very early in life. Our hypothesis is that compared to current single vaccine schedules, a combination of vaccines starting at 1 month of age, may provide earlier, ...
Source: BMJ Open - January 16, 2015 Category: Journals (General) Authors: Leach, A. J., Mulholland, E. K., Santosham, M., Torzillo, P. J., Brown, N. J., McIntyre, P., Smith-Vaughan, H., Skull, S., Balloch, A., Andrews, R., Carapetis, J., McDonnell, J., Krause, V., Morris, P. S., Grierson, Wilson, Birt, Hayes, Wienert, Nankervis Tags: Open access, Ear, nose and throat/otolaryngology, Immunology (including allergy), Infectious diseases, Paediatrics Protocol Source Type: research
Clinical Characteristics of Adults with Chronic Rhinosinusitis and Specific Antibody Deficiency
Conclusions Of the 239 patients with CRS with normal IgG levels evaluated for immunodeficiency, 56 (23.4%) had SAD. A majority of patients with SAD may not need Ig replacement; however, a subset of patients with SAD benefit from Ig replacement.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 18, 2014 Category: Allergy & Immunology Source Type: research
