B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children

B Cell Reconstitution and Influencing Factors After Hematopoietic Stem Cell Transplantation in Children Nicolaas G. van der Maas, Dagmar Berghuis, Mirjam van der Burg and Arjan C. Lankester* Willem-Alexander Children's Hospital, Department of Pediatrics and Laboratory for Pediatric Immunology, Leiden University Medical Center, Leiden, Netherlands B cell reconstitution after hematopoietic stem cell transplantation (HSCT) is variable and influenced by different patient, donor, and treatment related factors. In this review we describe B cell reconstitution after pediatric allogeneic HST, including the kinetics of reconstitution of the different B cell subsets and the development of the B cell repertoire, and discuss the influencing factors. Observational studies show important roles for stem cell source, conditioning regimen, and graft vs. host disease in B cell reconstitution. In addition, B cell recovery can play an important role in post-transplant infections and vaccine responses to encapsulated bacteria, such as pneumococcus. A substantial number of patients experience impaired B cell function and/or dependency on Ig substitution after allogeneic HSCT. The underlying mechanisms are largely unresolved. The integrated aspects of B cell recovery after HSCT, especially BCR repertoire reconstitution, are awaiting further investigation using modern techniques in order to gain more insight into B cell reconstitution and to develop strategies to improve humoral imm...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

Which CKD patients may need measured GFR -- and why? A new review examines the question.Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
New technology and better coordination have sped up development. But a coronavirus vaccine is still months — and most likely years — away.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Vaccination and Immunization Coronavirus (2019-nCoV) Epidemics SARS (Severe Acute Respiratory Syndrome) MERS (Middle East Respiratory Syndrome) Zika Virus Clinical Trials Moderna Therapeutics Johnson & University of Queensland Inovio Source Type: news
AbstractWe performed a prospective study to evaluate the types and characteristics of central nervous system (CNS) disorders in patients after hematopoietic stem cell transplantation. The study included 163 episodes of CNS disorders of which 58 (36%) were infections. Proven or probable infections were documented in 34 patients and included fungi (n = 10, 29%), viruses (n = 12, 35%),Toxoplasma spp. (n = 9, 27%) and bacteria (n = 3, 9%). Non-infectious neurological disorders (n = 105, 64%) frequently encompassed metabolic/drug-induced abnormalities (n&thin...
Source: Journal of Neurology - Category: Neurology Source Type: research
Russia and China are working to develop a coronavirus vaccine and Beijing has handed over the genome of the virus to Moscow, a Russian diplomatic mission in China said on Wednesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
CONCLUSION: Our results indicate the potential role of immediate (5 min) or early (15 min) acquisition in replacement of standardized 240 minutes acquisition in PD patients, but this result is not confirmed in HF patients, in which the acquisition at 240 min is confirmed as the most affordable timing for image interpretation, emphasizing the different pathophysiology that underlies these two pathologies. PMID: 31985388 [PubMed - as supplied by publisher]
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research
When Justin Steece ventures out of his apartment in Wuhan, his primary worry isn’t getting sick. He’s more concerned that he might bring the deadly pneumonia-like virus circulating the city back home to his wife and newborn baby. But with supplies of infant formula getting low, Steece doesn’t have much of a choice. “He’s a very chill kid and doesn’t cry much unless he’s hungry,” Steece, 26, from Lake George, Minn., who works as a teacher in Wuhan, tells TIME. “My biggest fear is that I’ll go out and accidentally transmit the disease to my family.” At 3 a.m. ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized China Infectious Disease onetime overnight Source Type: news
Abstract Background: Historically, Iceland has been an iodine-sufficient nation due to notably high fish and milk consumption. Recent data suggest that the intake of these important dietary sources of iodine has decreased considerably. Objective: To evaluate the iodine status of pregnant women in Iceland and to determine dietary factors associated with risk for deficiency. Methods: Subjects were women (n = 983; 73% of the eligible sample) attending their first ultrasound appointment in gestational weeks 11-14 in the period October 2017-March 2018. Spot urine samples were collected for assessment of urina...
Source: Food and Nutrition Research - Category: Nutrition Authors: Tags: Food Nutr Res Source Type: research
Abstract Quality-certified, nutritious novel groundnut spread has great commercialization possibilities due to evolving urban lifestyles in Africa, but lack of information about likability, sensory attributes, and consumer safety awareness is a severe barrier for small enterprises. This paper examines a novel groundnut spread, made of sorted kernels deemed free of aflatoxin, intended for use on bread in a fashion similar to groundnut paste or groundnut butter, but with modified sensory characteristics. In particular, it seeks to measure the effects of sensory attributes of the novel spread on the intent to pay for...
Source: Food and Nutrition Research - Category: Nutrition Authors: Tags: Food Nutr Res Source Type: research
Authors: Vania R, Pranata R, Tan ST Abstract Introduction: Warts can be difficult to treat and progressing to chronic and resistant disease. Several studies have reported the successful application of mumps-measles-rubella (MMR) vaccine resulting in clearance of warts via immunomodulation and induction of immune system.Methods: We performed a comprehensive search on the role of intralesional MMR in warts from several electronic databases. Complete response is defined as complete clearance of warts lesion.Results: There were a total of 425 subjects from five studies. Intralesional injection of MMR was associated wit...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
In this study we examined the effect of Compound A, N-(2-Aminoethyl)-5-chloro-1H-indol-2-carboxamide a H4 receptor antagonist in allergic asthma mice model. Objective: To investigate the anti-asthmatic effect of compound A in in vivo, airway inflammation in ovalbumin (OVA) induced allergic asthma mouse model was used.Methodology: Allergic asthma was induced in Balb/c mice using ovalbumin. BAL fluid was examined for the level of IgE, IL-4, IL-5, IL-13 and IL-17 using ELISA. Furthermore, infiltration of leucocytes by histopathology and effect of compound A on signalling molecules were examined in lung tissue.Results: In mice...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
More News: Academia | Acute Leukemia | Acute Myeloid Leukemia | Allergy | Allergy & Immunology | Bone Graft | Bone Marrow Transplant | Brazil Health | Bronchiolitis | Cancer & Oncology | Child Development | Children | Chronic Leukemia | Chronic Lymphocytic Leukemia | Databases & Libraries | Diphtheria | Epidemiology | France Health | Genetics | Haemophilus Influenzae (Hib) | Hematology | Hospitals | Immunotherapy | Influenza Vaccine | Laboratory Medicine | Leukemia | Measles | Measles Vaccine | Men | Meningitis Vaccine | Mumps | Mumps Vaccine | Myeloma | Netherlands Health | Parasitic Diseases | Parasitology | Pathology | Pediatrics | PET Scan | Pneomococcal Vaccine | Polio | Polio Vaccine | Portugal Health | Primary Immunodeficiency Disease | Reproduction Medicine | Rituxan | Rubella | Rubella Vaccine | Science | Splenectomy | Stem Cell Therapy | Stem Cells | Study | Sweden Health | Toxicology | Transplants | Vaccines | Velcade