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Total 83 results found since Jan 2013.

Immunologic Adverse Effects of Biologics for the Treatment of Atopy
AbstractThe use of biologic agents as therapies for atopic diseases such as asthma and atopic dermatitis has increased greatly in recent years. The biological agents used to treat atopic diseases are for the most part monoclonal antibodies that suppress the immune response and reduce inflammation by targeting particular cytokines or other molecules involved in Th1, Th2, or Th17 immune reactions. Various side effects and rare complications have been reported from these agents. In this review, we discuss mechanisms of various adverse effects for the biologic agents currently in use or in development for atopic and inflammato...
Source: Clinical Reviews in Allergy and Immunology - July 12, 2019 Category: Allergy & Immunology Source Type: research

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Ketogenic Diet as a Treatment for Super-Refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome
Conclusions: The characteristic EEG pattern in the acute phase promoted timely diagnosis of FIRES. Our data suggest that KD may be a safe and promising therapy for FIRES with SRSE, and that early initiation of KD produces a favorable prognosis. Therefore, KD should be applied earlier in the course of FIRES. Intravenous KD can be an effective alternative route of administration for patients who may not take KD enterally. Introduction Febrile infection-related epilepsy syndrome (FIRES) is a rare epileptic encephalopathy of unknown etiology which occurs in patients without active epilepsy or underlying neurological diso...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Phase 1 clinical study to assess the safety of a novel drug delivery system providing long ‐term topical steroid therapy for chronic rhinosinusitis
ConclusionLYR ‐210 is safe and well‐tolerated in ESS‐naive CRS patients and leads to sustained symptom improvement in patients.
Source: International Forum of Allergy and Rhinology - March 27, 2019 Category: Allergy & Immunology Authors: Richard G. Douglas, Alkis J. Psaltis, Joanne Rimmer, Tom Kuruvilla, Anders Cervin, Yina Kuang Tags: ORIGINAL ARTICLE Source Type: research

A Comprehensive Systematic Review of the Association Between Airway Mucins and Chronic Rhinosinusitis.
CONCLUSION: There is a strong correlation between alterations in mucin expression profiles and CRS. This systematic review highlights the most recent literature on the role of mucins in CRS. The analysis of these studies is limited by the heterogeneity in study designs, relatively few numbers of clinical samples, and lack of mechanistic studies in animal models and in vitro cultures. PMID: 30892914 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - March 19, 2019 Category: ENT & OMF Authors: Kato K, Song BH, Howe CL, Chang EH Tags: Am J Rhinol Allergy Source Type: research

The neuroplastic effect of olfactory training to the recovery of olfactory system in mouse model
ConclusionOT improved olfactory function, as indicated by the food ‐finding test. OT improved the olfactory recovery time to stimulate olfactory nerve regeneration. OT may initially stimulate the olfactory receptor, followed by neurogenesis. Steroid therapy and OT operated under completely different mechanisms in the upregulated gene study. These results indicate that OT may be one of the future modalities for treating olfactory impairment.
Source: International Forum of Allergy and Rhinology - February 21, 2019 Category: Allergy & Immunology Authors: Boo ‐Young Kim, Ju Yeon Park, Eui Jin Kim, Byung Guk Kim, Sung Won Kim, Soo Whan Kim Tags: ORIGINAL ARTICLE Source Type: research

Phase 1 clinical study to assess the safety of a novel drug delivery system providing long ‐term topical steroid therapy for chronic rhinosinusitis
ConclusionLYR ‐210 is safe and well‐tolerated in ESS‐naive CRS patients and leads to sustained symptom improvement in patients.
Source: International Forum of Allergy and Rhinology - January 15, 2019 Category: Allergy & Immunology Authors: Richard G. Douglas, Alkis J. Psaltis, Joanne Rimmer, Tom Kuruvilla, Anders Cervin, Yina Kuang Tags: ORIGINAL ARTICLE Source Type: research

Mast cells in mastocytosis and allergy – Important player in metabolic and immunological homeostasis
Publication date: March 2019Source: Advances in Medical Sciences, Volume 64, Issue 1Author(s): Joanna Renke, Sabina Kędzierska-Mieszkowska, Magdalena Lange, Bogusław Nedoszytko, Eliza Wasilewska, Anna Liberek, Marcin Renke, Marek Niedoszytko, Jacek Witkowski, Joanna Skórko-Glonek, Barbara LipińskaAbstractThe role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell m...
Source: Advances in Medical Sciences - January 13, 2019 Category: Biomedical Science Source Type: research

Mast cells in mastocytosis and allergy - Important player in metabolic and immunological homeostasis.
Abstract The role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell mediators, especially those released from mast cells in degranulation, but also those released constitutively, are important both in metabolic and immunological processes. Mastocytosis is a heterogeneous group of disorders characterized by accumulation of MC in one or more organs. There are s...
Source: Advances in Medical Sciences - January 11, 2019 Category: Biomedical Science Authors: Renke J, Kędzierska-Mieszkowska S, Lange M, Nedoszytko B, Wasilewska E, Liberek A, Renke M, Niedoszytko M, Witkowski J, Skórko-Glonek J, Lipińska B Tags: Adv Med Sci Source Type: research

Pediatric eosinophilic esophagitis: updates for the primary care setting
Purpose of review Eosinophilic esophagitis (EoE) is a multifactorial, non-IgE-mediated inflammatory disorder of the esophagus and is the most common cause of food impaction in the pediatric population. The purpose of this review is to describe the current recommendations for diagnosis and management of EoE. Recent findings New data has associated EoE with other allergic disorders of the atopic march as well as several risk factors, which predispose to allergic conditions. A subset of patients with esophageal eosinophilia respond to proton pump inhibitor (PPI) therapy with a partial or complete resolution of esophageal...
Source: Current Opinion in Pediatrics - December 1, 2018 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

Overlapping biological drugs prescription status: real life in Genoa
Conclusion: This study involving selected patients with severe asthma underlines the possible overlap in the choice of biological treatments. With the current lack of a reliable biomarker that orient us towards a more precise use of these drugs, so far a detailed clinical history and objective examination remain central. Despite this approach could be, now suitable, in the near future it will be no longer sufficient, the identification of a single, or a panel of biomarkers, would be mandatory.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Bagnasco, D., Aloe', T., Bondavalli, T., Testino, E., Manfredi, A., Passalacqua, G. Tags: Clinical Problems Source Type: research

Pediatric eosinophilic esophagitis: updates for the primary care setting
Purpose of review Eosinophilic esophagitis (EoE) is a multifactorial, non-IgE-mediated inflammatory disorder of the esophagus and is the most common cause of food impaction in the pediatric population. The purpose of this review is to describe the current recommendations for diagnosis and management of EoE. Recent findings New data has associated EoE with other allergic disorders of the atopic march as well as several risk factors, which predispose to allergic conditions. A subset of patients with esophageal eosinophilia respond to proton pump inhibitor (PPI) therapy with a partial or complete resolution of esophageal...
Source: Current Opinion in Pediatrics - November 10, 2018 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Henry H. Bernstein Source Type: research

Multiphasic treatment modality for pediatric eosinophilic gastroenteritis, a single center experience
Treatment of eosinophilic gastroenteritis (EG) in pediatrics is challenging. Options available include systemic immune modulators as well as targeted dietary restriction. Both regimens are difficult to adhere to given the adverse effects of systemic steroid therapy and compliance difficulties with diet restriction. At our institution we have found that only 25% of patients with EG respond to diet restriction. Here we describe the presentation and outcome of pediatric EG patients placed on a unique multiphasic steroid treatment.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: K. Kennedy, M. Ruffner, A. Muir Tags: P403 Source Type: research

A Pilot Study Investigating the Impact of Topical Nasal Steroid Spray in Allergic Rhinitis Patients with Dry Eye
Conclusion: In our study, symptoms of dry eye with allergic rhinitis were significantly improved with nasal steroid therapy, without affecting the intraocular pressure.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - May 7, 2018 Category: Allergy & Immunology Source Type: research