Ketogenic Diet as a Treatment for Super-Refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome

Conclusions: The characteristic EEG pattern in the acute phase promoted timely diagnosis of FIRES. Our data suggest that KD may be a safe and promising therapy for FIRES with SRSE, and that early initiation of KD produces a favorable prognosis. Therefore, KD should be applied earlier in the course of FIRES. Intravenous KD can be an effective alternative route of administration for patients who may not take KD enterally. Introduction Febrile infection-related epilepsy syndrome (FIRES) is a rare epileptic encephalopathy of unknown etiology which occurs in patients without active epilepsy or underlying neurological disorders. It is characterized by new onset of refractory status epilepticus (SE) following a short nonspecific febrile illness (1). It is a biphasic disease, with an acute phase of refractory SE that always transforms into super-refractory SE (SRSE, i.e., SE that continues or recurs 24 h or more after the onset of anesthesia). This condition often requires intensive care and management, and it often progresses to a chronic phase which is characterized by refractory epilepsy without an intervening silent period. In the acute phase, the risk of mortality is high. Moreover, survivors are likely to live with a drug-resistant epilepsy and neuropsychological impairment. Nevertheless, few individuals do not experience neurologic sequelae or mild learning difficulties (2). Multiple therapeutic modalities have been reported for this disease, but most of them do not effe...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Publication date: Available online 21 September 2019Source: Carbohydrate PolymersAuthor(s): Ana Letícia Rodrigues Costa, Andresa Gomes, Guilherme de Figueiredo Furtado, Heloisa Tibolla, Florencia Cecilia Menegalli, Rosiane Lopes CunhaAbstractAn in vitro digestibility protocol was used to elucidate the role of different emulsifying polysaccharides particles on the lipid digestion rate of oil-in-water Pickering emulsions. Emulsions stabilized by cellulose crystals (CCrys), cellulose nanofibers (CNFs), chitosan particles and a conventional emulsifier (Tween 80) were evaluated concerning microstructure, droplet size, ze...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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