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Condition: Asthma
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Anxiety in adults with asthma during the coronavirus disease 2019 pandemic: a Canadian perspective
Asthma is a chronic airway inflammatory disease that affects millions of Canadians and often contributes to higher levels of anxiety among patients. Since the coronavirus disease 2019 (COVID-19) pandemic was a...
Source: Allergy, Asthma and Clinical Immunology - August 23, 2023 Category: Allergy & Immunology Authors: Sophia Linton, Kayley Xu, Lubnaa Hossenbaccus, Hannah Botting, Sarah Garvey, Adam Sunavsky, Lisa M. Steacy, Dean A. Tripp and Anne K. Ellis Tags: Research Source Type: research
Assessment of Anxiety, Depression, and Sleep Quality in Mothers of Children with Atopic Dermatitis: A Qualitative Questionnaire Study
Source: Journal of Asthma and Allergy - August 22, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Population-level trends in asthma and chronic obstructive pulmonary disease emergency department visits and hospitalizations before and during the coronavirus disease 2019 pandemic in the United States
Previous studies have identified reductions in exacerbations of chronic lung disease in many locales after onset of the coronavirus disease 2019 (COVID-19) pandemic.
Source: Annals of Allergy, Asthma and Immunology - August 22, 2023 Category: Allergy & Immunology Authors: Adam Gaffney, David U. Himmelstein, Steffie Woolhandler Source Type: research
Tezepelumab reduces exacerbations across all seasons in patients with severe, uncontrolled asthma (NAVIGATOR)
Asthma exacerbation frequencies vary throughout the year owing to seasonal triggers. Tezepelumab is a human monoclonal antibody that targets thymic stromal lymphopoietin. In the phase 3 NAVIGATOR study (NCT03347279), tezepelumab significantly reduced the annualized asthma exacerbation rate (AAER) versus placebo in patients with severe, uncontrolled asthma.
Source: Annals of Allergy, Asthma and Immunology - August 22, 2023 Category: Allergy & Immunology Authors: Ian D. Pavord, Flavia C.L. Hoyte, Andrew W. Lindsley, Christopher S. Ambrose, Joseph D. Spahn, Stephanie L. Roseti, Bill Cook, Janet M. Griffiths, Åsa Hellqvist, Nicole Martin, Jean-Pierre Llanos, Neil Martin, Gene Colice, Jonathan Corren Tags: Original Article Source Type: research
Population-Level Trends in Asthma and COPD Emergency Department Visits and Hospitalizations Before and During the COVID-19 Pandemic in the US
Previous studies have identified reductions in exacerbations of chronic lung disease in many locales after onset of the COVID-19 pandemic.
Source: Annals of Allergy, Asthma and Immunology - August 22, 2023 Category: Allergy & Immunology Authors: Adam Gaffney, David U. Himmelstein, Steffie Woolhandler Tags: Original Article Source Type: research
The US HAEA Scientific Registry: Hereditary Angioedema Demographics, Disease Severity, and Comorbidities
Hereditary Angioedema (HAE) and idiopathic non-histaminergic angioedema (INHA) are ultra-rare diseases whose natural histories and comorbidities are incompletely understood.
Source: Annals of Allergy, Asthma and Immunology - August 22, 2023 Category: Allergy & Immunology Authors: Sandra C. Christiansen, Joyce Wilmot, Anthony J. Castaldo, Bruce L. Zuraw, US HAEA Medical Advisory Board members Tags: Original Article Source Type: research
Epigenetic histone modification by butyrate downregulates KIT and attenuates mast cell function
J Cell Mol Med. 2023 Aug 21. doi: 10.1111/jcmm.17924. Online ahead of print.ABSTRACTShort-chain fatty acid butyrate is produced from the bacterial fermentation of indigestible fiber in the intestinal lumen, and it has been shown to attenuate lung inflammation in murine asthma models. Mast cells (MCs) are initiators of inflammatory response to allergens, and they play an important role in asthma. MC survival and proliferation is regulated by its growth factor stem cell factor (SCF), which acts through the receptor, KIT. It has previously been shown that butyrate attenuates the activation of MCs by allergen stimulation. Howe...
Source: Molecular Medicine - August 21, 2023 Category: Molecular Biology Authors: Ravindra Gudneppanavar Emma Elizabeth Sabu Kattuman Lakshminarayan Reddy Teegala Erik Southard Ramakumar Tummala Bina Joe Charles K Thodeti Sailaja Paruchuri Source Type: research
High Transcriptional Activity and Clinical Correlations in Eosinophils of Patients with Late-Onset Asthma
Source: Journal of Asthma and Allergy - August 21, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
When Nutrition Trends and Food Allergies Collide
Local food customs, once relatively static, are increasingly influenced by consumer demand for new products, changing tastes, and evolving health trends in a global food market. Moreover, with growing consumer concern for the environment, animal welfare, and the quest for sustainable food sources, novel ingredients are emerging and with these, potential allergies to these foods. Food allergen labeling laws reduce the risk of inadvertent exposure to known allergens. However, labeling laws vary by country or region and only priority allergens, those responsible for the vast majority of allergic reactions, require full disclo...
Source: Annals of Allergy, Asthma and Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Marion Groetch, Isabel Skypala Tags: Perspective Source Type: research
How Does Global Warming Contribute to Disorders Originating from an Impaired Epithelial Barrier?
The epithelial barrier represents the point of contact between the host and the external environment. It is the first line of defense against external insults in the skin, gastrointestinal and upper and lower respiratory tracts. The steep increase in chronic disorders in recent decades, including allergies and autoimmune disorders, has prompted studies to investigate the immune mechanisms of their underlying pathogeneses, all of which point to a thought-provoking shared finding: disrupted epithelial barriers.
Source: Annals of Allergy, Asthma and Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Cevdet Ozdemir, Umut Can Kucuksezer, Ismail Ogulur, Yagiz Pat, Duygu Yazici, Ioana Agache, Marek Jutel, Kari C. Nadeau, M übeccel Akdis, Cezmi A. Akdis Tags: Review Source Type: research
Extreme Weather Events and Asthma
The objective of this article is to review recent literature on the implications of extreme weather events such as thunderstorms, wildfires, tropical cyclones, freshwater flooding, and temperature extremes in relationship to asthma symptoms. Several studies have shown worsening of asthma symptoms with thunderstorms, wildfires, tropical cyclones, freshwater flooding, and temperature extremes. In particular, thunderstorm asthma can be exacerbated by certain factors such as temperature, precipitation, and allergen sensitization. Therefore, it is imperative that the allergy and immunology community be aware of the health effec...
Source: Immunology and Allergy Clinics of North America - August 21, 2023 Category: Allergy & Immunology Authors: Jennilee Luedders, Jill A. Poole, Andrew C. Rorie Source Type: research
Anaphylaxis and systemic mastocytosis controlled with KIT inhibitors in a patient with metastatic lung adenocarcinoma
Ann Allergy Asthma Immunol. 2023 Aug 17:S1081-1206(23)00570-7. doi: 10.1016/j.anai.2023.08.009. Online ahead of print.NO ABSTRACTPMID:37597693 | DOI:10.1016/j.anai.2023.08.009
Source: Annals of Allergy, Asthma and Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Camellia L Hernandez Donna-Marie Lynch Abby Jane Golash Kathleen Marquis Kylie Marie Besz Geoffrey Oxnard Julia Rotow Daniel J DeAngelo Mariana Castells Source Type: research
