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Consensus of an ACAAI, AAAAI, and ATS Workgroup on Definition of Clinical Remission in Asthma on Treatment
As more and better therapies for the treatment of asthma are developed, the approach to classification of asthma control has been in transition. With the availability of inhaled corticosteroids (ICS) as a treatment class came the introduction of control measures utilizing guideline-based criteria, which included validated tools such as the Asthma Control Test (ACT), Baseline Asthma Impairment and Risk Questionnaire (AirQ) and the Asthma Control Questionnaire (ACQ)1,2,3. Following the addition of long-acting bronchodilator (LABA) therapy, Bateman and colleagues described a measure of total control in the GOAL study, definin...
Source: Annals of Allergy, Asthma and Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Michael Blaiss, John Oppenheimer, Mark Corbett, Len Bacharier, Jonathan Bernstein, Tara Carr, Bradley Chipps, Simon Couillard, Erick Forno, Torie Grant, Njira Lugogo, Kathleen May, Eric Schauberger Source Type: research
Defining remission in asthma care
Treatments for asthma continue to evolve and with the development of biologics, we are now entering an arena where some patients appear to have their asthma symptoms disappear entirely. This dramatic improvement in a chronic disease is reminiscent of remission in other chronic illnesses, such as rheumatoid arthritis, but until now there has been no accepted definition for remission in asthma. In this issue of Annals, a workgroup that involved asthma experts from North America have put together a list of 6 criteria that they have defined as indicating remission of asthma.
Source: Annals of Allergy, Asthma and Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Mitchell H Grayson, Paul V. Williams Tags: Editorial Source Type: research
Prenatal exposures to mixtures of endocrine disrupting chemicals and sex-specific associations with children's BMI and overweight at 5.5 years of age in the SELMA study
CONCLUSION: Prenatal exposure to a mixture of EDCs was associated with lower BMI and overweight among girls, and non-significant associations among boys. Chemicals of concern for girls included phthalates, non-phthalate plasticizers, bisphenols, PAHs, and PFAS.PMID:37672941 | DOI:10.1016/j.envint.2023.108176
Source: Environment International - September 6, 2023 Category: Environmental Health Authors: Katherine Svensson Chris Gennings Christian Lindh Hannu Kiviranta Panu Rantakokko Sverre Wikstr öm Carl-Gustaf Bornehag Source Type: research
Ozone Pollution and Acute Exacerbation of Asthma in Residents of China: An Ecological Study
Source: Journal of Asthma and Allergy - September 6, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Lung Function and Asthma Clinical Control in N-ERD Patients, Three-Year Follow-Up in the Context of Real-World Evidence
Source: Journal of Asthma and Allergy - September 6, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Assessing Available Adolescent Self-Reported Measures for Asthma Management: A Systematic Literature Review
Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.
Source: Pediatric, Allergy, Immunology, and Pulmonology - September 6, 2023 Category: Respiratory Medicine Authors: Elif Isik Gardner Mack Marianna M. Sockrider Nina M. Fredland Ross Shegog Source Type: research
Factors by which Global Warming Worsens Allergic Disease
Increased use of fossil fuels has led to global warming with concomitant increases in the severity and frequency of extreme weather events such as wildfires and sand and dust storms. These changes have led to increases in air pollutants such as particulate matter and greenhouse gases. Global warming is also associated with increases in pollen season length and pollen concentration. Particulate matter, greenhouse gases, and pollen synergistically increase incidence and severity of allergic diseases.
Source: Annals of Allergy, Asthma and Immunology - September 6, 2023 Category: Allergy & Immunology Authors: Hana Seastedt, Kari Nadeau Tags: CME Reviews Source Type: research
Type 2 biomarkers and quality of life in chronic rhinosinusitis with nasal polyps
Historically chronic rhinosinusitis (CRS) has been categorized as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP) 1. EPOS2020 guidelines suggest classifying CRS based on type 2 (T2) biomarkers 2. T2 inflammation is responsible for driving the disease in 80-90% of CRSwNP patients 1. In clinical practice, peripheral blood eosinophils (PBE) and total immunoglobulin E (IgE) may help assess, but cannot fully confirm, whether CRS is driven by T2 inflammation. PBE and IgE reflect T2 cytokines IL-5 and IL-4/IL-13, respectively.
Source: Annals of Allergy, Asthma and Immunology - September 6, 2023 Category: Allergy & Immunology Authors: Rasads Misirovs, Rory Chan, Brian Lipworth Tags: Letters Source Type: research
Managing Anaphylaxis – Epinephrine, Antihistamines, and Corticosteroids: Over 10 years of C-CARE Registry Data
Epinephrine is the first-line treatment for anaphylaxis but is often replaced with antihistamines or corticosteroids. Delayed epinephrine administration is a risk factor for fatal anaphylaxis. Convincing data on the role of antihistamines and corticosteroids in anaphylaxis management is sparse.
Source: Annals of Allergy, Asthma and Immunology - September 6, 2023 Category: Allergy & Immunology Authors: Luca Delli Colli, Adnan Al Ali, Sofianne Gabrielli, Marina Delli Colli, Pasquale Mule, Benjamin Lawson, Ann. E. Clarke, Judy Morris, Jocelyn Gravel, Rod Lim, Edmond S. Chan, Ran D. Goldman, Andrew O'Keefe, Jennifer Gerdts, Derek K. Chu, Julia Upton, Elana Tags: Original Article Source Type: research
The chronic rhinosinusitis practice parameter
Ann Allergy Asthma Immunol. 2023 Sep;131(3):307-310. doi: 10.1016/j.anai.2022.12.022. Epub 2022 Dec 17.ABSTRACTThe Allergy-Immunology Joint Task Force on Practice Parameters has published the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines for the medical management of chronic rhinosinusitis with nasal polyposis (CRSwNP). The practice parameter provides evidence-based guidelines on the use of intranasal corticosteroids (INCS) and biologics for CRSwNP, and aspirin therapy after desensitization (ATAD) for the management of aspirin-exacerbated respiratory disease (AERD). Evidence on surge...
Source: Annals of Allergy, Asthma and Immunology - September 5, 2023 Category: Allergy & Immunology Authors: So Lim Kim Matthew A Rank Anju Tripathi Peters Source Type: research
Generalized urticaria following the use of e-cigarette: a case reported during a switching trial
E-cigarettes (ECs) are popular, yet controversial, tobacco-cigarette substitutes among smokers worldwide1 and are typically used by US youth.2
Source: Annals of Allergy, Asthma and Immunology - September 5, 2023 Category: Allergy & Immunology Authors: Stefan Gospodaru, Gheorghe Bordeniuc, Valeriu Fala, Thomas Bruce Casale, Riccardo Polosa Tags: Letters Source Type: research
