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Anaphylaxis and systemic mastocytosis controlled with KIT inhibitors in a patient with metastatic lung adenocarcinoma
Ann Allergy Asthma Immunol. 2023 Aug 17:S1081-1206(23)00570-7. doi: 10.1016/j.anai.2023.08.009. Online ahead of print.NO ABSTRACTPMID:37597693 | DOI:10.1016/j.anai.2023.08.009
Source: Annals of Allergy, Asthma and Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Camellia L Hernandez Donna-Marie Lynch Abby Jane Golash Kathleen Marquis Kylie Marie Besz Geoffrey Oxnard Julia Rotow Daniel J DeAngelo Mariana Castells Source Type: research

Emerging Concepts in Neuropathic and Neurogenic Itch
Ann Allergy Asthma Immunol. 2023 Aug 17:S1081-1206(23)00571-9. doi: 10.1016/j.anai.2023.08.008. Online ahead of print.ABSTRACTChronic pruritus has multiple etiologies, ranging from inflammatory to metabolic and neuropathic processes. However, recent advances in itch biology have shed light on potential mechanisms that explain the molecular and cellular basis of these pathologies. Further, new understanding of neuroimmune itch circuits necessitates clarification of terminologies such as "neuropathic" and "neurogenic". This review provides an overview of how new concepts may better explain the pathophysiology of a variety of...
Source: Annals of Allergy, Asthma and Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Kelsey L Auyeung Brian S Kim Source Type: research

Anaphylaxis and systemic mastocytosis controlled with KIT inhibitors in a patient with metastatic lung adenocarcinoma
Ann Allergy Asthma Immunol. 2023 Aug 17:S1081-1206(23)00570-7. doi: 10.1016/j.anai.2023.08.009. Online ahead of print.NO ABSTRACTPMID:37597693 | DOI:10.1016/j.anai.2023.08.009
Source: Annals of Allergy, Asthma and Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Camellia L Hernandez Donna-Marie Lynch Abby Jane Golash Kathleen Marquis Kylie Marie Besz Geoffrey Oxnard Julia Rotow Daniel J DeAngelo Mariana Castells Source Type: research

Emerging Concepts in Neuropathic and Neurogenic Itch
Ann Allergy Asthma Immunol. 2023 Aug 17:S1081-1206(23)00571-9. doi: 10.1016/j.anai.2023.08.008. Online ahead of print.ABSTRACTChronic pruritus has multiple etiologies, ranging from inflammatory to metabolic and neuropathic processes. However, recent advances in itch biology have shed light on potential mechanisms that explain the molecular and cellular basis of these pathologies. Further, new understanding of neuroimmune itch circuits necessitates clarification of terminologies such as "neuropathic" and "neurogenic". This review provides an overview of how new concepts may better explain the pathophysiology of a variety of...
Source: Annals of Allergy, Asthma and Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Kelsey L Auyeung Brian S Kim Source Type: research

Anaphylaxis and systemic mastocytosis controlled with KIT inhibitors in a patient with metastatic lung adenocarcinoma
Ann Allergy Asthma Immunol. 2023 Aug 17:S1081-1206(23)00570-7. doi: 10.1016/j.anai.2023.08.009. Online ahead of print.NO ABSTRACTPMID:37597693 | DOI:10.1016/j.anai.2023.08.009
Source: Annals of Allergy, Asthma and Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Camellia L Hernandez Donna-Marie Lynch Abby Jane Golash Kathleen Marquis Kylie Marie Besz Geoffrey Oxnard Julia Rotow Daniel J DeAngelo Mariana Castells Source Type: research

Emerging Concepts in Neuropathic and Neurogenic Itch
Ann Allergy Asthma Immunol. 2023 Aug 17:S1081-1206(23)00571-9. doi: 10.1016/j.anai.2023.08.008. Online ahead of print.ABSTRACTChronic pruritus has multiple etiologies, ranging from inflammatory to metabolic and neuropathic processes. However, recent advances in itch biology have shed light on potential mechanisms that explain the molecular and cellular basis of these pathologies. Further, new understanding of neuroimmune itch circuits necessitates clarification of terminologies such as "neuropathic" and "neurogenic". This review provides an overview of how new concepts may better explain the pathophysiology of a variety of...
Source: Annals of Allergy, Asthma and Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Kelsey L Auyeung Brian S Kim Source Type: research

Childhood Respiratory Viral Infections and the Microbiome
The human microbiome associated with the respiratory tract is diverse, heterogeneous, and dynamic. The diversity and complexity of the microbiome and the interactions between microorganisms, host cells, and the host immune system are complex and multifactorial. Furthermore, the lymphatics provide a direct highway, the gut-lung axis, for the gut microbiome to affect outcomes related to respiratory disease and the host immune response. Viral infections in the airways can also alter the presence or absence of bacterial species, which might increase the risks for allergies and asthma.
Source: Journal of Allergy and Clinical Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Kirsten M. Kloepfer, Joshua L. Kennedy Source Type: research

Progress in Understanding if Respiratory Syncytial Virus Infection in Infancy Causes Asthma in Childhood
Source: Journal of Allergy and Clinical Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Christian Rosas-Salazar, Kohei Hasegawa, Tina V. Hartert Source Type: research

CMV retinitis in patients on mycophenolate immunosuppression: a report of two cases
The rate of cytomegalovirus (CMV) retinitis is increasing, likely secondary to aggressive immunosuppressive regimens for a variety of diseases. Transplant and rheumatological literature show growing evidence s...
Source: Allergy, Asthma and Clinical Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Prem N. Patel, Ahmed M. Alkaliby, Mitul C. Mehta and Angeline L. Wang Tags: Case report Source Type: research

Immune response after SARS-CoV-2 vaccination in patients with inflammatory immune-mediated diseases receiving immunosuppressive treatment
Real world data on the response to the SARS-CoV-2 vaccine in patients with immunomediated diseases (IMIDs) treated with immunesuppressants is of great interest because vaccine response may be impaired. The mai...
Source: Allergy, Asthma and Clinical Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Chamaida Plasencia-Rodr íguez, Ana Martínez-Feito, Marta Hernández, Lucia Del Pino-Molina, Marta Novella-Navarro, Yolanda Serrano, Miguel González-Muñoz, Diana Peiteado, Gema Bonilla, Irene Monjo, Laura Nuño, Carolina Tornero, Eduardo López-Granado Tags: Research Source Type: research

The impact of temperature on the skin barrier and atopic dermatitis
Ann Allergy Asthma Immunol. 2023 Aug 16:S1081-1206(23)00569-0. doi: 10.1016/j.anai.2023.08.007. Online ahead of print.ABSTRACTClimate change is a global threat to public health and causes/worsens various diseases including atopic dermatitis (AD), allergic, infectious, cardiovascular diseases, physical injuries and mental disorders. The incidence of allergy, such as AD, has increased over the last several decades, and environmental factors such as climate change have been implicated as a potential mechanism. A significant amount of literature has been published on the impact of climate factors, including cold and hot temper...
Source: Annals of Allergy, Asthma and Immunology - August 18, 2023 Category: Allergy & Immunology Authors: Jessica Hui-Beckman Elena Goleva Donald Y M Leung Byung Eui Kim Source Type: research

Food Allergies: Diagnosis, Treatment, and Prevention
Am Fam Physician. 2023 Aug;108(2):159-165.ABSTRACTIn the United States, approximately 2% to 3% of adults and 8% of children have a food allergy. Allergic reactions range from minor pruritus to life-threatening anaphylaxis. These allergies often lead to significant anxiety and costs for patients and caregivers. Common food allergies include peanuts, cow's milk, shellfish, tree nuts, egg, fish, soy, and wheat. Peanut allergy, the most common, is the leading cause of life-threatening anaphylaxis. Children with asthma, allergic rhinitis, atopic dermatitis, or an allergy to insect venom, medications, or latex are at an increase...
Source: American Family Physician - August 17, 2023 Category: Primary Care Authors: Dellyse M Bright Holly Leigh Stegall David C Slawson Source Type: research

Chronic oral exposure to low-concentration fumonisin B2 significantly exacerbates the inflammatory responses of allergies in mice via inhibition of IL-10 release by regulatory T cells in gut-associated lymphoid tissue
Arch Toxicol. 2023 Aug 17. doi: 10.1007/s00204-023-03579-0. Online ahead of print.ABSTRACTContamination with fumonisins produced by Fusarium spp. is rapidly growing in both developing and developed countries. The purpose of this study was to determine whether oral exposure to fumonisin contributed to the development of allergic diseases. We initially examined the immunotoxic potential of short-term, oral administration of fumonisin B1 (FB1, 1 mg/kg) and fumonisin B2 (FB2, 1 mg/kg), both naturally occurring fumonisins, using a BALB/c mouse model of allergic contact dermatitis and Dermatophagoides farina-induced asthma. Usin...
Source: Archives of Toxicology - August 17, 2023 Category: Toxicology Authors: Mana Ando Hiroki Yamaguchi Ai Morimoto Naoki Iwashita Yoshiichi Takagi Masaki Nagane Tomoya Yoshinari Tomoki Fukuyama Source Type: research