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Spring health cheat sheet
The beginning of spring often brings warm weather and hours of outdoor fun, and many common winter infections recede. Unfortunately, spring weather can bring its own health challenges. As soon as the trees and flowers bloom, flowers bud and the grass grows, susceptible children will start to display symptoms of seasonal allergies. Seasonal allergies cause sneezing, runny nose and itchy red eyes and can trigger flares of asthma and eczema. As children spend more time outdoors, parents also need to watch for exposure to ticks, poison ivy and excess sun. Read on for the parents’ guide to spring health. Seasonal allergies: ...
Source: Thrive, Children's Hospital Boston - March 29, 2016 Category: Pediatrics Authors: Carolyn Sax Tags: Health & Wellness Parenting allergies asthma Carolyn Sax conjunctivitis lyme disease poion ivy sunburn Source Type: news

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids
Conclusion In Table 1, an overview is presented of the complex roles of AAs described in this review regarding the microbiome-gut-immune-brain axis in ASD. Besides behavioral deficits, people with ASD are characterized by systemic inflammation, gastrointestinal immune-related disturbances and changes in the gut microbiota composition. Moreover, differences in levels of specific AAs in various body compartments, including the intestinal tract, blood, urine and brain have been reported in patients with ASD, as well as in rodent models for ASD. This review described that specific AAs can modulate the intestinal epithelial im...
Source: Frontiers in Endocrinology - April 15, 2019 Category: Endocrinology Source Type: research

The Epigenetics of Food Allergy.
Authors: Chang C, Wu H, Lu Q Abstract Food allergy is a global health problem, particularly in developed countries. It is mainly mediated by Th2 cell and IgE produced by B cells. While the pathogenesis of IgE-mediated food allergy is quite straightforward, the factors that lead to the development of food allergies at any age in children and adults are unclear. Recent studies have revealed that genetics, epigenetics, and environmental exposures contribute to the development of atopy. In this chapter, we discuss the interplay between these three key elements, reveal how epigenetic modifications may mediate genetic su...
Source: Advances in Experimental Medicine and Biology - May 25, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Abstract PR03: Association of environmental risk factors, family history, and polygenic risk scores with chronic lymphocytic leukemia
Conclusions: We found evidence of independent effects among the genetic and non-genetic factors with risk of CLL. Among these factors, the PRS had the largest effect size. Although we did not observe any statistical interactions, larger sample sizes are warranted to fully evaluate these effects on risk of CLL. We are currently increasing our sample size through collaboration with other research groups. Final results will be presented in the meeting.This abstract is also being presented as Poster A06.Citation Format: Geffen Kleinstern, Dennis Robinson, Tim G. Call, Mark Liebow, Silvia de Sanjosé, Yolanda Benavente, J...
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Kleinstern, G., Robinson, D., Call, T. G., Liebow, M., Sanjose, S. d., Benavente, Y., Cerhan, J. R., Slager, S. L. Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Proffered Abstracts Source Type: research

Elemental Sulfur Use and Associations with Pediatric Lung Function and Respiratory Symptoms in an Agricultural Community (California, USA)
Conclusions: This study suggests that elemental sulfur use, allowed in both organic and conventional farming, in close proximity to residential areas, may adversely affect children’s respiratory health. https://doi.org/10.1289/EHP528 Received: 19 May 2016 Revised: 05 May 2017 Accepted: 09 May 2017 Published: 14 August 2017 Address correspondence to R. Raanan, Center for Environmental Research and Children’s Health (CERCH), University of California, Berkeley, School of Public Health, 1995 University Ave., Suite 265, Berkeley, CA 94704 USA. Telephone: (510) 642-9431. Email: rachelraananrr@gmail.com Supplemental Ma...
Source: EHP Research - August 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

In Brief: Severe Hypersensitivity Reactions with Rolapitant IV Emulsion (Varubi)
Date: January 29, 2018 Issue #:  1539Summary:  The FDA has warned that the IV emulsion formulation of the substance P/neurokinin 1 (NK1) receptor antagonist rolapitant(Varubi) has been associated in postmarketing reports with serious hypersensitivity reactions including anaphylaxis and anaphylactic shock.1 Rolapitant was approved by the FDA as an oral tablet in 2015 for adjunctive prevention of delayed nausea and vomiting associated with cancer chemotherapy in adults2; the IV emulsion formulation of the drug was approved for the same indication in 2017.The reported hypersensitivity reactions oc...
Source: The Medical Letter - January 23, 2018 Category: Drugs & Pharmacology Authors: admin Source Type: research

Here ’s Everything You Need to Know About Gut Health
It’s hardly news that the gastrointestinal tract is important to human health: It transports food from the mouth to the stomach, converts it into absorbable nutrients and stored energy, and shuttles waste back out of the body. If you don’t properly nourish yourself, you don’t live. It’s that simple. But in recent years, scientists have discovered that the GI system has an even bigger, more complex job than previously appreciated. It’s been linked to numerous aspects of health that have seemingly nothing to do with digestion, from immunity to emotional stress to chronic illnesses, including can...
Source: TIME: Health - March 25, 2019 Category: Consumer Health News Authors: Amanda MacMillan Tags: Uncategorized Research Source Type: news

Safety, Efficacy, and Clinical Impact of Penicillin Skin Testing in Immunocompromised Cancer Patients
ConclusionOur findings support PST use in immunocompromised hosts. The widespread use of PST in patients with cancer will allow for optimal use of antimicrobial therapy and stewardship, which are vital in a population at increased risk for infections.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 28, 2019 Category: Allergy & Immunology Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

Inpatient Direct Oral Penicillin Challenge – A Large Prospective Cohort Study
Penicillin allergies are associated with inferior patient and antimicrobial stewardship outcomes. The long-term implementation (3.5 years) of a whole-of-hospital program to assess the safety of inpatient delabeling by direct oral challenge for low-risk penicillin allergies in hospitalized inpatients at Austin Hospital and the Peter MacCallum Cancer Centre, Australia was described here.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Kyra Chua, Sara Vogrin, Jamie Waldron, Elise Mitri, Rebecca Hall, Ana Maria Copaescu, Natasha Holmes, Jason Trubiano Source Type: research

Evaluation of micronuclear frequencies in both circulating lymphocytes and buccal epithelial cells of patients with oral lichen planus and oral lichenoid contact reactions
ConclusionsMN scores do not distinguish OLP from OLCR when using buccal smears but significant differences were observed in peripheral lymphocytes. OLP and OLCR both demonstrated significantly higher MN frequencies in both buccal and circulating lymphocytes cells, compared with healthy controls. MN assesment in both buccal epithelial cells and circulating lymphocytes may serve as a potential biomarker tool for evaluating any cancer risk in OLP and OLCR.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - July 31, 2013 Category: ENT & OMF Authors: A. Saruhanoğlu, S. Ergun, M. Kaya, S. Warnakulasuriya, M. Erbağcı, Ş. Öztürk, E. Deniz, S. Özel, K. Çefle, Ş. Palanduz, H. Tanyeri Tags: Original Article Source Type: research

Diet of hookworms to tackle a bread allergy
James Logan, a biologist at the School of Hygiene and Tropical Medicine also tried leeches and is thinking about maggot therapy• Read about more scientists who go to extremes lengthsA lot of people don't realise that just one metre below your feet walking along Gower Street or Malet Street in London, you have thousands upon thousands of very hungry, potentially dangerous insects.In the basement we have our insectary colonies where we keep lots of different species of mosquitoes, found in all parts of the world. None of them are infected with malaria, but they are in very high numbers. We also have bed bugs, house dust mi...
Source: Guardian Unlimited Science - December 1, 2013 Category: Science Authors: Josh Davis Tags: Allergies Health Medical research Society Technology Features Animals Insects The Observer Environment Science Wildlife Source Type: news

5 Scary Symptoms That Are Usually Harmless
SPECIAL FROM Next Avenue By Linda Melone After 50, aches, pains and the occasional muscle twinge become a fact of life. But some symptoms that may seem frightening or serious turn out to be far less than they appear. While you should always see a doctor if you experience something out of the ordinary, these signs generally are more smoke than fire: A Bloody Nose Nosebleeds can be particularly frightening due to the suddenness in which they occur and the sometimes large amount of blood involved. “People worry that it’s internal bleeding, but almost every time it’s not,” says Dr. Carlo Reyes, emergency room...
Source: Healthy Living - The Huffington Post - February 5, 2015 Category: Consumer Health News Source Type: news

Why Would I Be Low in Vitamin D?
My doctors and I test blood levels of vitamin D on everyone we see in our clinic. When the results come in, two things happen: 1. Pretty much everyone is low in vitamin D. 2. Pretty much everyone is shocked that they are low in vitamin D. Why worry about vitamin D? It's important. Multiple studies have shown that people with low levels of Vitamin D have the following: • Weaker bones [1] • Higher mortality rate [2] • More allergies and asthma [3] • Greater risk of cancer [4] • Higher risk of diabetes [5] • Greater risk of heart attacks [6] • Higher rates of MS [7] • Higher risk of infections [8] • More me...
Source: Healthy Living - The Huffington Post - November 20, 2015 Category: Consumer Health News Source Type: news