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Developing the WCRF International/University of Bristol Methodology for Identifying and Carrying Out Systematic Reviews of Mechanisms of Exposure-Cancer Associations
Conclusions: We have developed novel tools for identifying mechanisms and carrying out systematic reviews of mechanistic studies of exposure–disease relationships. In doing so, we have outlined how we have overcome the challenges that we faced and provided researchers with practical guides for conducting mechanistic systematic reviews. Impact: The aforementioned methodology and tools will allow potential mechanisms to be identified and the strength of the evidence underlying a particular mechanism to be assessed. Cancer Epidemiol Biomarkers Prev; 26(11); 1667–75. ©2017 AACR. (Source: Cancer Epidemiology Bi...
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Lewis, S. J., Gardner, M., Higgins, J., Holly, J. M. P., Gaunt, T. R., Perks, C. M., Turner, S. D., Rinaldi, S., Thomas, S., Harrison, S., Lennon, R. J., Tan, V., Borwick, C., Emmett, P., Jeffreys, M., Northstone, K., Mitrou, G., Wiseman, M., Thompson, R. Tags: Research Articles Source Type: research

Relationships between Circulating and Intraprostatic Sex Steroid Hormone Concentrations
Conclusions: Circulating concentrations of sex steroid hormones are poor surrogate measures of the intraprostatic hormonal milieu. Impact: The high exposure misclassification provided by circulating sex steroid hormone concentrations for intraprostatic levels may partly explain the lack of any consistent association of circulating hormones with prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 26(11); 1660–6. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Cook, M. B., Stanczyk, F. Z., Wood, S. N., Pfeiffer, R. M., Hafi, M., Veneroso, C. C., Lynch, B., Falk, R. T., Zhou, C. K., Niwa, S., Emanuel, E., Gao, Y.-T., Hemstreet, G. P., Zolfghari, L., Carroll, P. R., Manyak, M. J., Sesterhann, I. A., Levine, P. H. Tags: Research Articles Source Type: research

Vasectomy and Risk of Prostate Cancer in a Screening Trial
Conclusions: Vasectomy was not associated with prostate cancer risk among men who were screened for prostate cancer as part of a clinical trial, but was associated with prostate cancer detection in men receiving usual care. Impact: The positive association between vasectomy and prostate cancer is likely related to increased detection of prostate cancer based on patterns of care rather than a biological effect of vasectomy on prostate cancer development. Cancer Epidemiol Biomarkers Prev; 26(11); 1653–9. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Shoag, J., Savenkov, O., Christos, P. J., Mittal, S., Halpern, J. A., Askin, G., Shoag, D., Golan, R., Lee, D. J., O'Malley, P., Najari, B., Eisner, B., Hu, J. C., Scherr, D., Schlegel, P., Barbieri, C. E. Tags: Research Articles Source Type: research

Cannabis Use and Incidence of Testicular Cancer: A 42-Year Follow-up of Swedish Men between 1970 and 2011
Conclusions: The current study provides additional evidence to the limited prior literature suggesting cannabis use may contribute to the development of testicular cancer. Impact: Emerging changes to cannabis drug policy should consider the potential role of cannabis use in the development of testicular cancer. Cancer Epidemiol Biomarkers Prev; 26(11); 1644–52. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Callaghan, R. C., Allebeck, P., Akre, O., McGlynn, K. A., Sidorchuk, A. Tags: Research Articles Source Type: research

Indoor Tanning Dependence in Young Adult Women
Background: There is mounting evidence that young people can develop a dependence on indoor tanning, but research on factors associated with indoor tanning dependence remains limited. Methods: This cross-sectional study investigated factors associated with indoor tanning dependence in a community sample of 389 non-Hispanic white young adult women ages 18 to 30 who had indoor tanned ≥1 time in the past year. Participants completed measures of indoor tanning dependence, including the modified CAGE and modified Diagnostic and Statistical Manual for Mental Disorders-IV psychiatric screening assessments, indoor tanning behav...
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Mays, D., Atkins, M. B., Ahn, J., Tercyak, K. P. Tags: Research Articles Source Type: research

Defining Optimal Triage Strategies for hrHPV Screen-Positive Women--An Evaluation of HPV 16/18 Genotyping, Cytology, and p16/Ki-67 Cytoimmunochemistry
Conclusions: All three single-test triage options, if positive, exceed the threshold of 20% risk at which colposcopy would be indicated. However, none of them conferred a post-test probability of CIN2+ 20%, whereas women who tested negative had a probability of CIN2+ of
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Stanczuk, G. A., Baxter, G. J., Currie, H., Forson, W., Lawrence, J. R., Cuschieri, K., Wilson, A., Patterson, L., Govan, L., Black, J., Palmer, T., Arbyn, M. Tags: Research Articles Source Type: research

A Novel 18-Marker Panel Predicting Clinical Outcome in Breast Cancer
Conclusions: Our findings demonstrated that the 18 molecular markers were strong predictors of breast cancer–specific mortality. The stable time-dependent area under the ROC curve function (AUC(t)) and high C-indices in the training and validation cohorts were further improved by fitting a combined model consisting of the 18-marker panel and established clinical markers. Impact: Our work supports the applicability of this 18-marker panel to improve clinical outcome prediction for breast cancer patients. Cancer Epidemiol Biomarkers Prev; 26(11); 1619–28. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Biermann, J., Nemes, S., Parris, T. Z., Engqvist, H., Rönnerman, E. W., Forssell-Aronsson, E., Steineck, G., Karlsson, P., Helou, K. Tags: Research Articles Source Type: research

An Exploration of Changes in the Measurement of Mammography in the National Health Interview Survey
Conclusions: Self-reports of mammography are sensitive to question wording. Researchers should use equivalent questions that have been designed to minimize response biases such as telescoping and social desirability. Impact: Trend analyses relying on differently worded questions may be misleading and conceal disparities. Cancer Epidemiol Biomarkers Prev; 26(11); 1611–8. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Gonzales, F. A., Willis, G. B., Breen, N., Yan, T., Cronin, K. A., Taplin, S. H., Yu, M. Tags: Research Articles Source Type: research

Use of Antihypertensive Medications and Risk of Adverse Breast Cancer Outcomes in a SEER-Medicare Population
Conclusions: Use of diuretics and β-blockers may be associated with increased risk of breast cancer outcomes among older women. Impact: Most antihypertensive medications are safe with respect to breast cancer outcomes, but more research is needed for diuretics and β-blockers. Cancer Epidemiol Biomarkers Prev; 26(11); 1603–10. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Chen, L., Chubak, J., Boudreau, D. M., Barlow, W. E., Weiss, N. S., Li, C. I. Tags: Research Articles Source Type: research

Cell-Free Circulating DNA Integrity Based on Peripheral Blood as a Biomarker for Diagnosis of Cancer: A Systematic Review
Conclusions: This review suggests that cfDI is controversial as a blood-based biomarker of cancers, although the sensitivity and AUC were relatively high. Impact: cfDI shows heterogeneity between different studies; more perspective studies are needed to further assess its diagnostic performance, especially with other markers in combination. Cancer Epidemiol Biomarkers Prev; 26(11); 1595–602. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Cheng, J., Tang, Q., Cao, X., Burwinkel, B. Tags: Reviews Source Type: research

A Comparative Study on the WCRF International/University of Bristol Methodology for Systematic Reviews of Mechanisms Underpinning Exposure-Cancer Associations
The World Cancer Research Fund (WCRF) International and the University of Bristol have developed a novel framework for providing an overview of mechanistic pathways and conducting a systematic literature review of the biologically plausible mechanisms underlying exposure–cancer associations. Two teams independently applied the two-stage framework on mechanisms underpinning the association between body fatness and breast cancer to test the framework feasibility and reproducibility as part of a WCRF-commissioned validation study. In stage I, a "hypothesis-free" approach was used to provide an overview of pote...
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Ertaylan, G., Le Cornet, C., van Roekel, E. H., Jung, A. Y., Bours, M. J. L., Damms-Machado, A., van den Brandt, P. A., Schock, H., de Kok, T. M., Theys, J., Arts, I. C. W., Kaaks, R., Weijenberg, M. P., Fortner, R. T. Tags: Reviews Source Type: research

On the Facilitation of Collaborative Research: Enter Stage Left, the Consortium Director
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Authors: Rolland, B., Potter, J. D. Tags: Commentary Source Type: research

Highlights of This Issue
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 31, 2017 Category: Cancer & Oncology Tags: Highlights Source Type: research

Cigarette Prices and Smoking Cessation--Letter
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Braillon, A. Tags: Letter to the Editor Source Type: research

Explaining the Obesity Paradox--Response
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Caan, B. J., Meyerhardt, J. A., Prado, C. M. Tags: Letter to the Editor Source Type: research

Explaining the Obesity Paradox--Letter
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Winkels, R. M., van Zutphen, M., Kampman, E., van Baar, H., Beijer, S. Tags: Letter to the Editor Source Type: research

The Prevalence of Cancer-Associated Autoantibodies in Patients with Gastric Cancer and Progressive Grades of Premalignant Lesions
Conclusions: Our results suggest that humoral immune response against TAAs is generated already during premalignant stages. Impact: Based on the obtained results, cancer-associated autoantibodies might make a valuable contribution to the stratification of high-risk patients with premalignant lesions in the stomach through enhancing the positive predictive power of existing risk models. Cancer Epidemiol Biomarkers Prev; 26(10); 1564–74. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Meistere, I., Werner, S., Zayakin, P., Silina, K., Rulle, U., Pismennaja, A., Santare, D., Kikuste, I., Isajevs, S., Leja, M., Kupcinskas, L., Kupcinskas, J., Jonaitis, L., Wu, C.-Y., Brenner, H., Line, A., Kalnina, Z. Tags: Research Articles Source Type: research

Mediating Effect of Postsurgical Chemotherapy on Presence of Dementia and Survival among Patients 65 and Older with Stage III Colon Cancer
Conclusions: Preexisting dementia is significantly associated with worse survival for stage III colon cancer patients, and its deleterious effect is partially explained by decreased likelihood of postoperative chemotherapy receipt. Impact: This is the first study that provides estimate of the mediating effect of diminished chemotherapy in patients with stage III colon cancer and dementia, simultaneously demonstrating the cancer-specific survival benefit of chemotherapy in the presence of dementia. Cancer Epidemiol Biomarkers Prev; 26(10); 1558–63. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Chen, Y., Cress, R. D., Stewart, S. L., Semrad, T. J., Harvey, D., Tencredi, D. J., Beckett, L. Tags: Research Articles Source Type: research

A Prospective Study of Chronic Inflammation in Benign Prostate Tissue and Risk of Prostate Cancer: Linked PCPT and SELECT Cohorts
Background: We leveraged two trials to test the hypothesis of an inflammation–prostate cancer link prospectively in men without indication for biopsy. Methods: Prostate Cancer Prevention Trial (PCPT) participants who had an end-of-study biopsy performed per protocol that was negative for cancer and who subsequently enrolled in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) were eligible. We selected all 100 cases and sampled 200 frequency-matched controls and used PCPT end-of-study biopsies as "baseline." Five men with PSA> 4 ng/mL at end-of-study biopsy were excluded. Tissue was located for...
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Platz, E. A., Kulac, I., Barber, J. R., Drake, C. G., Joshu, C. E., Nelson, W. G., Lucia, M. S., Klein, E. A., Lippman, S. M., Parnes, H. L., Thompson, I. M., Goodman, P. J., Tangen, C. M., De Marzo, A. M. Tags: Research Articles Source Type: research

Impact of Sixteen Established Pancreatic Cancer Susceptibility Loci in American Jews
Conclusions: The 16 pancreatic cancer susceptibility loci similarly impact Jewish and non-Jewish white European subjects, both individually and as summary odds. Impact: These 16 pancreatic cancer susceptibility loci likely do not explain the higher risk seen in Ashkenazi Jews. Cancer Epidemiol Biomarkers Prev; 26(10); 1540–8. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Streicher, S. A., Klein, A. P., Olson, S. H., Amundadottir, L. T., DeWan, A. T., Zhao, H., Risch, H. A. Tags: Research Articles Source Type: research

Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations
Conclusions: Gene and network analysis uncovered loci associated with ALL that are missed by GWA studies, such as MEIS1. Furthermore, ALL-associated loci do not appear to interact directly with each other to influence ALL risk, and instead appear to influence leukemogenesis through multiple, complex pathways. Impact: We present a new pipeline for post hoc analysis of association studies that yields new insight into the etiology of ALL and can be applied in future studies to shed light on the genomic underpinnings of cancer. Cancer Epidemiol Biomarkers Prev; 26(10); 1531–9. ©2017 AACR. (Source: Cancer Epidemiolog...
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Nakka, P., Archer, N. P., Xu, H., Lupo, P. J., Raphael, B. J., Yang, J. J., Ramachandran, S. Tags: Research Articles Source Type: research

Tobacco Product Use Patterns, and Nicotine and Tobacco-Specific Nitrosamine Exposure: NHANES 1999-2012
Background: Few studies have examined differences in product consumption patterns and nicotine and tobacco-specific nitrosamines (TSNA) exposure between single versus dual- and poly-tobacco users. We applied the Tobacco Product Use Patterns (T-PUPs) model to fill this gap in the literature. Methods: Data from adults (age ≥18 years) who used any tobacco products during the 5 days prior to participating in the 1999–2012 National Health and Nutrition Examination Survey (NHANES) were analyzed. Participants were classified into seven T-PUPs: (1) cigarettes only, (2) noncigarette combustibles only, (3) noncombustibles o...
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Choi, K., Sabado, M., El-Toukhy, S., Vogtmann, E., Freedman, N. D., Hatsukami, D. Tags: Research Articles Source Type: research

Serum Insulin, Glucose, Indices of Insulin Resistance, and Risk of Lung Cancer
Conclusions: Higher fasting serum insulin concentrations, as well as the presence of insulin resistance, appear to be associated with an elevated risk of lung cancer development. Impact: Although insulin is hypothesized to increase risk of some cancers, insulin and lung cancer remain understudied. Higher insulin levels and insulin resistance were associated with increased lung cancer risk. Although smoking cessation is the best method of lung cancer prevention, other lifestyle changes that affect insulin concentrations and sensitivity may reduce lung cancer risk. Cancer Epidemiol Biomarkers Prev; 26(10); 1519–24. &co...
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Argirion, I., Weinstein, S. J., Männistö, S., Albanes, D., Mondul, A. M. Tags: Research Articles Source Type: research

Recent Trends in Ovarian Cancer Incidence and Relative Survival in the United States by Race/Ethnicity and Histologic Subtypes
Conclusions: Over the last decade, incidence rates of epithelial ovarian cancer in the United States have decreased or remained stable across race/ethnic and histologic subgroups, except for clear cell carcinoma. Survival remains poorest among NHB women. Impact: Comparative histologic subtype distribution and incidence trends do not explain the ovarian cancer survival disparity disproportionately affecting NHB women. Cancer Epidemiol Biomarkers Prev; 26(10); 1511–8. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Park, H. K., Ruterbusch, J. J., Cote, M. L. Tags: Research Articles Source Type: research

The Cost-Effectiveness of Visual Triage of Human Papillomavirus-Positive Women in Three Low- and Middle-Income Countries
Conclusions: VIA triage of HPV-positive women is not likely to be cost-effective in settings with high cervical cancer burden. HPV alone followed by treatment may achieve greater health benefits and value for public health dollars. Impact: This study provides early evidence on the cost-effectiveness of HPV testing followed by VIA triage versus an HPV screen-and-treat strategy. Cancer Epidemiol Biomarkers Prev; 26(10); 1500–10. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Campos, N. G., Jeronimo, J., Tsu, V., Castle, P. E., Mvundura, M., Kim, J. J. Tags: Research Articles Source Type: research

Cervical Cancer Screening among Women from Muslim-Majority Countries in Ontario, Canada
Conclusions: We have shown that being born in a Muslim-majority country is associated with a decreased likelihood of being up-to-date on cervical screening in Ontario and that access to primary care has a sizeable impact on screening uptake. Impact: Screening efforts need to take into account the background characteristics of population subgroups and to focus on increasing primary care access for all. Cancer Epidemiol Biomarkers Prev; 26(10); 1493–9. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Lofters, A. K., Vahabi, M., Kim, E., Ellison, L., Graves, E., Glazier, R. H. Tags: Research Articles Source Type: research

The Association of Mammographic Density and Molecular Breast Cancer Subtype
Conclusions: Increased MD is more strongly associated with H2P tumors when compared with LA. Impact: Delineating risk factors specific to breast cancer subtype may promote development of individualized risk prediction models and screening strategies. Cancer Epidemiol Biomarkers Prev; 26(10); 1487–92. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Edwards, B. L., Atkins, K. A., Stukenborg, G. J., Novicoff, W. M., Larson, K. N., Cohn, W. F., Harvey, J. A., Schroen, A. T. Tags: Research Articles Source Type: research

Associations of Coffee Drinking and Cancer Mortality in the Cancer Prevention Study-II
Conclusions: These findings are consistent with many other studies that suggest coffee drinking is associated with a lower risk of colorectal, liver, female breast, and head and neck cancer. The association of coffee consumption with higher risk of esophageal cancer among nonsmokers in our study should be confirmed. Impact: These results underscore the importance of assessing associations between coffee consumption and cancer mortality by smoking status. Cancer Epidemiol Biomarkers Prev; 26(10); 1477–86. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Authors: Gapstur, S. M., Anderson, R. L., Campbell, P. T., Jacobs, E. J., Hartman, T. J., Hildebrand, J. S., Wang, Y., McCullough, M. L. Tags: Research Articles Source Type: research

Highlights of This Issue
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - October 1, 2017 Category: Cancer & Oncology Tags: Highlights Source Type: research

Gestational Diabetes Mellitus and Incident Invasive Breast Cancer--Letter
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Mormile, R. Tags: Letter to the Editor Source Type: research

History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium
Conclusions: Histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival. Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis. Cancer Epidemiol Biomarkers Prev; 26(9); 1470–3. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Minlikeeva, A. N., Freudenheim, J. L., Eng, K. H., Cannioto, R. A., Friel, G., Szender, J. B., Segal, B., Odunsi, K., Mayor, P., Diergaarde, B., Zsiros, E., Kelemen, L. E., Köbel, M., Steed, H., deFazio, A., on behalf of the Australian Ovarian Can Tags: Null Results in Brief Source Type: research

Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study
Conclusions: Our results suggest that previously reported differences in breast cancer survival by genetic ancestry may be overcome by improving health care access and/or quality. Impact: Improving health care access and quality may reduce breast cancer disparities among U.S. Latinas. Cancer Epidemiol Biomarkers Prev; 26(9); 1466–9. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Engmann, N. J., Ergas, I. J., Yao, S., Kwan, M. L., Roh, J. M., Ambrosone, C. B., Kushi, L. H., Fejerman, L. Tags: Null Results in Brief Source Type: research

Genome-Wide Testing of Exonic Variants and Breast Cancer Risk in the California Teachers Study
Conclusions: We did not detect any novel statistically significant exonic variants with overall breast cancer risk or by subtype. Impact: Exonic variants in the exome chip may not be associated with overall breast cancer or subtype susceptibility. Cancer Epidemiol Biomarkers Prev; 26(9); 1462–5. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Lacson, J. C. A., Ma, H., Lee, E., Neuhausen, S. L., Anton-Culver, H., Reynolds, P., Nelson, D. O., Ziogas, A., Van Den Berg, D., Deapen, D. M., Bernstein, L., Schumacher, F. R. Tags: Null Results in Brief Source Type: research

No Association of Vitamin D Pathway Genetic Variants with Cancer Risks in a Population-Based Cohort of German Older Adults
Conclusions: Our data provide little to no evidence of a major influence of vitamin D genetic predisposition on cancer risks. Impact: Large-scale genetic epidemiology consortia and meta-analysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of vitamin D with the risk of cancer. Cancer Epidemiol Biomarkers Prev; 26(9); 1459–61. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Ordonez-Mena, J. M., Schöttker, B., Saum, K. U., Holleczek, B., Burwinkel, B., Wang, T. J., Brenner, H. Tags: Null Results in Brief Source Type: research

Age at Menarche and Late Adolescent Adiposity Associated with Mammographic Density on Processed Digital Mammograms in 24,840 Women
Background: High mammographic density is strongly associated with increased breast cancer risk. Some, but not all, risk factors for breast cancer are also associated with higher mammographic density. Methods: The study cohort (N = 24,840) was drawn from the Research Program in Genes, Environment and Health of Kaiser Permanente Northern California and included non-Hispanic white females ages 40 to 74 years with a full-field digital mammogram (FFDM). Percent density (PD) and dense area (DA) were measured by a radiological technologist using Cumulus. The association of age at menarche and late adolescent body mass index (BMI)...
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Alexeeff, S. E., Odo, N. U., Lipson, J. A., Achacoso, N., Rothstein, J. H., Yaffe, M. J., Liang, R. Y., Acton, L., McGuire, V., Whittemore, A. S., Rubin, D. L., Sieh, W., Habel, L. A. Tags: Research Articles Source Type: research

Medical Care Cost of Oropharyngeal Cancer among Texas Patients
Conclusions: Medical care cost was about $140,000 in the first 2 years after diagnosis of oropharyngeal cancer among commercially insured patients in Texas. Impact: The cost estimates provide important parameters for development of decision-analytic models to inform decision makers about the potential value of initiatives for increasing the HPV immunization rate in the state. Cancer Epidemiol Biomarkers Prev; 26(9); 1443–9. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Lairson, D. R., Wu, C.-F., Chan, W., Dahlstrom, K. R., Tam, S., Sturgis, E. M. Tags: Research Articles Source Type: research

Potential Susceptibility Loci Identified for Renal Cell Carcinoma by Targeting Obesity-Related Genes
Background: Obesity is an established risk factor for renal cell carcinoma (RCC). Although genome-wide association studies (GWAS) of RCC have identified several susceptibility loci, additional variants might be missed due to the highly conservative selection. Methods: We conducted a multiphase study utilizing three independent genome-wide scans at MD Anderson Cancer Center (MDA RCC GWAS and MDA RCC OncoArray) and National Cancer Institute (NCI RCC GWAS), which consisted of a total of 3,530 cases and 5,714 controls, to investigate genetic variations in obesity-related genes and RCC risk. Results: In the discovery phase, 32,...
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Shu, X., Purdue, M. P., Ye, Y., Tu, H., Wood, C. G., Tannir, N. M., Wang, Z., Albanes, D., Gapstur, S. M., Stevens, V. L., Rothman, N., Chanock, S. J., Wu, X. Tags: Research Articles Source Type: research

Quantifying the Genetic Correlation between Multiple Cancer Types
In this study, we estimated the pair-wise genetic correlation between six cancer types (breast, colorectal, lung, ovarian, pancreatic, and prostate) using cancer-specific GWAS summary statistics data based on 66,958 case and 70,665 control subjects of European ancestry. We also estimated genetic correlations between cancers and 14 noncancer diseases and traits. Results: After adjusting for 15 pair-wise genetic correlation tests between cancers, we found significant (P
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Lindström, S., Finucane, H., Bulik-Sullivan, B., Schumacher, F. R., Amos, C. I., Hung, R. J., Rand, K., Gruber, S. B., Conti, D., Permuth, J. B., Lin, H.-Y., Goode, E. L., Sellers, T. A., Amundadottir, L. T., Stolzenberg-Solomon, R., Klein, A., Pe Tags: Research Articles Source Type: research

How Many Deaths from Colorectal Cancer Can Be Prevented by 2030? A Scenario-Based Quantification of Risk Factor Modification, Screening, and Treatment in Norway
Conclusions: Risk factor modification, screening, and treatment all have considerable potential to reduce colorectal cancer mortality by 2030, with the largest potential reduction observed for improved treatment and risk factor modification. Impact: The estimation of these health impact measures provides useful information that can be applied in public health decision-making. Cancer Epidemiol Biomarkers Prev; 26(9); 1420–6. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Skyrud, K. D., Myklebust, T. A., Bray, F., Eriksen, M. T., de Lange, T., Larsen, I. K., Moller, B. Tags: Research Articles Source Type: research

Stool DNA Test of Methylated Syndecan-2 for the Early Detection of Colorectal Neoplasia
Conclusions: Fecal methylated SDC2 is a valuable biomarker for the noninvasive detection of colorectal neoplasms. Impact: Stool DNA test of methylated SDC2 would serve as an alternative method for screening colorectal neoplasms. Cancer Epidemiol Biomarkers Prev; 26(9); 1411–9. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Niu, F., Wen, J., Fu, X., Li, C., Zhao, R., Wu, S., Yu, H., Liu, X., Zhao, X., Liu, S., Wang, X., Wang, J., Zou, H. Tags: Research Articles Source Type: research

The Impact of a Population-Based Screening Program on Income- and Immigration-Related Disparities in Colorectal Cancer Screening
Conclusions: Introduction of a population-based screening program promoting FOBT for colorectal cancer was associated with only modest improvements in immigration and income-related disparities. Impact: Reducing immigration and income-related disparities should be a focus for future research and policy work. Disparities in Ontario seem to be driven by a higher uptake of colonoscopy among more advantaged groups. Cancer Epidemiol Biomarkers Prev; 26(9); 1401–10. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Kiran, T., Glazier, R. H., Moineddin, R., Gu, S., Wilton, A. S., Paszat, L. Tags: Research Articles Source Type: research

Colorectal Cancer Screening: How Health Gains and Cost-Effectiveness Vary by Ethnic Group, the Impact on Health Inequalities, and the Optimal Age Range to Screen
Conclusions: Colorectal cancer screening in NZ using FOBTi is likely to be cost-effective but risks increasing inequalities in health for Māori. Impact: To avoid or mitigate the generation of further health inequalities, attention should be given to underserved population groups when planning and implementing screening programs. Cancer Epidemiol Biomarkers Prev; 26(9); 1391–400. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: McLeod, M., Kvizhinadze, G., Boyd, M., Barendregt, J., Sarfati, D., Wilson, N., Blakely, T. Tags: Research Articles Source Type: research

The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies
The association between telomere length (TL) in peripheral blood cells and cancer risk remains inconclusive. We carried out a meta-analysis on prospective studies. The study-specific RR estimates were first transformed to a common comparable scale and then were pooled by a random-effects model. The dataset was composed of 13,894 cases and 71,672 controls from 28 studies in 25 articles. In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% confidence interval (CI), 0.952–1.238]. Subgroup analyses s...
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Zhang, X., Zhao, Q., Zhu, W., Liu, T., Xie, S.-H., Zhong, L.-X., Cai, Y.-Y., Li, X.-N., Liang, M., Chen, W., Hu, Q.-S., Zhang, B. Tags: Reviews Source Type: research

Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies
In conclusion, new high-dimensional exposure assessments offer many new opportunities for environmental assessment in cancer development. Cancer Epidemiol Biomarkers Prev; 26(9); 1370–80. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Patel, C. J., Kerr, J., Thomas, D. C., Mukherjee, B., Ritz, B., Chatterjee, N., Jankowska, M., Madan, J., Karagas, M. R., McAllister, K. A., Mechanic, L. E., Fallin, M. D., Ladd-Acosta, C., Blair, I. A., Teitelbaum, S. L., Amos, C. I. Tags: Reviews Source Type: research

The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium
This article describes the Group, including the rationale for its initial aims related to pregnancy, obesity, and physical activity. We also describe the 20 cohort studies with data submitted to the Group by June 2016. The infrastructure developed for this work can be leveraged to support additional investigations. Cancer Epidemiol Biomarkers Prev; 26(9); 1360–9. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Nichols, H. B., Schoemaker, M. J., Wright, L. B., McGowan, C., Brook, M. N., McClain, K. M., Jones, M. E., Adami, H.-O., Agnoli, C., Baglietto, L., Bernstein, L., Bertrand, K. A., Blot, W. J., Boutron-Ruault, M.-C., Butler, L., Chen, Y., Doody, M. M., Dos Tags: Reviews Source Type: research

Addressing Disparities: The 10th Anniversary of the AACR Cancer Health Disparities Conference
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Authors: Caligiuri, M. A. Tags: Commentary Source Type: research

Highlights of This Issue
(Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 31, 2017 Category: Cancer & Oncology Tags: Highlights Source Type: research

Coffee and Green Tea Consumption and Subsequent Risk of Malignant Lymphoma and Multiple Myeloma in Japan: The Japan Public Health Center-based Prospective Study
Conclusions: In this study, we observed no significant association between coffee or green tea consumption and the risk of malignant lymphoma or multiple myeloma. Impact: Our results do not support an association between coffee or green tea consumption and the risk of malignant lymphoma or multiple myeloma. Cancer Epidemiol Biomarkers Prev; 26(8); 1352–6. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 1, 2017 Category: Cancer & Oncology Authors: Ugai, T., Matsuo, K., Sawada, N., Iwasaki, M., Yamaji, T., Shimazu, T., Sasazuki, S., Inoue, M., Kanda, Y., Tsugane, S., on behalf of the Japan Public Health Center-based Prospective Study Group Tags: Null Results in Brief Source Type: research

Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium
Conclusions: None of the selected SNPs were convincingly associated with PNET risk in the PANDoRA consortium. Impact: We can exclude a major role of the selected polymorphisms in PNET etiology, and this highlights the need for replication of epidemiologic findings in independent populations, especially in rare diseases such as PNETs. Cancer Epidemiol Biomarkers Prev; 26(8); 1349–51. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 1, 2017 Category: Cancer & Oncology Authors: Campa, D., Obazee, O., Pastore, M., Panzuto, F., Lico, V., Greenhalf, W., Katzke, V., Tavano, F., Costello, E., Corbo, V., Talar-Wojnarowska, R., Strobel, O., Zambon, C. F., Neoptolemos, J. P., Zerboni, G., Kaaks, R., Key, T. J., Lombardo, C., Jamroziak, Tags: Null Results in Brief Source Type: research

Use of Calcium Channel Blockers and Breast Cancer Risk in the Women's Health Initiative
Conclusions: We provide additional evidence that CCBs do not influence breast cancer risk in postmenopausal women. Impact: The results from this study, which includes strong control for potential confounding factors, cast doubt on increases in risk with CCBs. Cancer Epidemiol Biomarkers Prev; 26(8); 1345–8. ©2017 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Source: Cancer Epidemiology Biomarkers and Prevention - August 1, 2017 Category: Cancer & Oncology Authors: Brasky, T. M., Krok-Schoen, J. L., Liu, J., Chlebowski, R. T., Freudenheim, J. L., Lavasani, S., Margolis, K. L., Qi, L., Reding, K. W., Shields, P. G., Simon, M. S., Wactawski-Wende, J., Wang, A., Womack, C., Manson, J. E. Tags: Null Results in Brief Source Type: research