Abstract PR03: Association of environmental risk factors, family history, and polygenic risk scores with chronic lymphocytic leukemia

Conclusions: We found evidence of independent effects among the genetic and non-genetic factors with risk of CLL. Among these factors, the PRS had the largest effect size. Although we did not observe any statistical interactions, larger sample sizes are warranted to fully evaluate these effects on risk of CLL. We are currently increasing our sample size through collaboration with other research groups. Final results will be presented in the meeting.This abstract is also being presented as Poster A06.Citation Format: Geffen Kleinstern, Dennis Robinson, Tim G. Call, Mark Liebow, Silvia de Sanjosé, Yolanda Benavente, James R. Cerhan, Susan L. Slager. Association of environmental risk factors, family history, and polygenic risk scores with chronic lymphocytic leukemia. [abstract]. In: Proceedings of the AACR Special Conference: Improving Cancer Risk Prediction for Prevention and Early Detection; Nov 16-19, 2016; Orlando, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(5 Suppl):Abstract nr PR03.

Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Kleinstern, G., Robinson, D., Call, T. G., Liebow, M., Sanjose, S. d., Benavente, Y., Cerhan, J. R., Slager, S. L. Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Proffered Abstracts Source Type: research