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Total 58 results found since Jan 2013.

Molecules, Vol. 28, Pages 2400: Bruton & rsquo;s Tyrosine Kinase Inhibitors (BTKIs): Review of Preclinical Studies and Evaluation of Clinical Trials
Molecules, Vol. 28, Pages 2400: Bruton’s Tyrosine Kinase Inhibitors (BTKIs): Review of Preclinical Studies and Evaluation of Clinical Trials Molecules doi: 10.3390/molecules28052400 Authors: Dariusz Rozkiewicz Justyna Magdalena Hermanowicz Iwona Kwiatkowska Anna Krupa Dariusz Pawlak In the last few decades, there has been a growing interest in Bruton’s tyrosine kinase (BTK) and the compounds that target it. BTK is a downstream mediator of the B-cell receptor (BCR) signaling pathway and affects B-cell proliferation and differentiation. Evidence demonstrating the expression of BTK on t...
Source: Molecules - March 6, 2023 Category: Chemistry Authors: Dariusz Rozkiewicz Justyna Magdalena Hermanowicz Iwona Kwiatkowska Anna Krupa Dariusz Pawlak Tags: Review Source Type: research

Two cases of eosinophilic gastrointestinal disorder due to newly appearing food allergies after cord blood transplantation
Transpl Immunol. 2023 Jan 2;77:101781. doi: 10.1016/j.trim.2022.101781. Online ahead of print.ABSTRACTEosinophilic gastrointestinal disorders (EGIDs) are infrequent complications after allogeneic hematopoietic cell transplantation (allo-HCT). Furthermore, it is well-known that allergic diseases are transferable after allo-HCT from allergic donors to non-allergic recipients. However, the type of graft-versus host disease (GVHD) prophylaxis that leads to allergic disease transfer is unclear. Furthermore, no study has reported a case of acquired food allergy resulting in EGID that was detected based on the clinical course and...
Source: Transplant Immunology - January 5, 2023 Category: Transplant Surgery Authors: Naonori Harada Yosuke Makuuchi Masatomo Kuno Teruhito Takakuwa Hiroshi Okamura Mitsutaka Nishimoto Yasuhiro Nakashima Hideo Koh Miho Sakaida Sayaka Tanaka Yuko Kuwae Akira Higashimori Fumino Tanaka Masahiko Ohsawa Yasuhiro Fujiwara Masayuki Hino Hirohisa Source Type: research

Novel peanut-specific human IgE monoclonal antibodies enable screens for inhibitors of the effector phase in food allergy
ConclusionAllergen-specific human IgE mAbs, expressed from human hybridomas and specific for a clinically relevant food allergen, passively sensitize allergy effector cells central to the in vitro models of the effector phase of food allergy. Peanut reproducibly activates and induces degranulation of RBL SX-38 cells sensitized with peanut-specific human IgE mAbs. This system provides a unique screening tool to assess the efficacy of therapeutics that target allergy effector cells and inhibit food allergen-induced effector cell activation.
Source: Frontiers in Immunology - September 29, 2022 Category: Allergy & Immunology Source Type: research

Betamethasone Dipropionate Derivatization, Biotransformation, Molecular Docking, and ADME Analysis as Glucocorticoid Receptor
Biomed Res Int. 2022 Jul 6;2022:6865472. doi: 10.1155/2022/6865472. eCollection 2022.ABSTRACTBetamethasone is an important glucocorticoids (GCs), frequently used to cure allergies (such as asthma and angioedema), Crohn's disease, skin diseases (such as dermatitis and psoriasis), systemic lupus erythematosus, rheumatic disorders, and leukemia. Present investigation deals to find potential agonist of glucocorticoid receptors after biotransformation of betamethasone dipropionate (1) and to carry out the molecular docking and ADME analyses. Biotransformation of 1 was carried out with Launaea capitata (dandy) roots and Musa acu...
Source: Biomed Res - July 22, 2022 Category: Research Authors: Sana Rashid Shazia Anjum Aqeel Ahmad Raziya Nadeem Maqsood Ahmed Syed Adnan Ali Shah Muhammad Abdullah Komal Zia Zaheer Ul-Haq Source Type: research

Vaccines against SARS ‐CoV‐2 are safe to administer in patients with antibodies to pegaspargase
ConclusionSARS-CoV-2 vaccination is safe in this population.
Source: Cancer Medicine - July 15, 2022 Category: Cancer & Oncology Authors: Hope D. Swanson, Hana Hakim, Diego R. Hijano, Ted Morton, Shane Cross, Hiroto Inaba, Sima Jeha, Ching ‐Hon Pui, Seth E. Karol Tags: BRIEF COMMUNICATION Source Type: research

Post-transplant food anaphylaxis in an adult cord blood transplant recipient (Ms. No. IJHM-D-20-01037R1)
Int J Hematol. 2021 Mar 27. doi: 10.1007/s12185-021-03140-8. Online ahead of print.ABSTRACTTransplant acquired food allergy (TAFA) is a well-known complication following pediatric liver transplantation, but post-cord blood transplantation (post-CBT) TAFA has rarely been reported. Here, we describe a case of new-onset food anaphylaxis after CBT in an adult patient that demonstrates that post-CBT allergen-challenge is not a risk for long-term allergic sensitization even in adult recipients. The patient was a 39-year-old Japanese man with aggressive NK cell leukemia. He had no previous history of allergies. After receiving CB...
Source: International Journal of Hematology - March 27, 2021 Category: Hematology Authors: Ai Kawahara Tsukasa Nakanishi Midori Goto Kenichi Akao Takefumi Katsuragi Junichi Tsukada Source Type: research

Inhibitory effects of cyanidin-3-O-glucoside in black soybean hull extract on RBL-2H3 cells degranulation and passive cutaneous anaphylaxis reaction in mice.
This study provides evidence for the potential use of BSHE and C3G for the prevention or the treatment of type I allergies. PMID: 33582590 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - February 11, 2021 Category: Allergy & Immunology Authors: Hiemori-Kondo M, Morikawa E, Fujikura M, Nagayasu A, Maekawa Y Tags: Int Immunopharmacol Source Type: research

Induction of apoptosis in breast cancer cells by naphthylisoquinoline alkaloids.
Abstract Breast cancer is one of the most common types of cancer in the world and a major cause of mortality. Present therapeutic strategies against breast cancer have severe drawbacks such as allergies, damage to healthy tissues, reoccurrence of cancer, and emergence of drug resistance. Naphthylisoquinoline alkaloids are a group of structurally unique natural products produced by tropical lianas belonging to the plant families Dioncophyllaceae and Ancistrocladaceae indigenous to Asia and Africa. These secondary metabolites have been reported to show anti-infective activity, but they also act against leukemic and ...
Source: Toxicology and Applied Pharmacology - October 19, 2020 Category: Toxicology Authors: Kushwaha PP, Singh AK, Prajapati KS, Shuaib M, Fayez S, Bringmann G, Kumar S Tags: Toxicol Appl Pharmacol Source Type: research

A 71-Year-Old Man With Chest Pain and a Solitary Pulmonary Mass.
Abstract CASE PRESENTATION: A 71-year-old man was admitted to our hospital because of diffuse chest pain and a mass on routine chest radiography. He did not report cough, dyspnea, fever, night sweats, or weight loss. His medical history was remarkable for chronic lymphocytic leukemia diagnosed 13 years before presentation, and secondary myelodysplastic syndrome diagnosed 2 years before the onset of the current symptoms. As a curative approach, he had received a matched unrelated stem cell transplantation 16 months earlier, and he had been in complete remission since. He developed chronic graft-vs-host disease, pr...
Source: Chest - August 31, 2020 Category: Respiratory Medicine Authors: Papan C, Langer F, Bittenbring JT, Schäfers HJ, Bohle RM, Fries P, Becker SL Tags: Chest Source Type: research

Persistent Basophilia May Suggest an “Accelerated Phase” in the Evolution of CALR-Positive Primary Myelofibrosis Toward Acute Myeloid Leukemia
Basophils are white blood cells that play an important role in the human immune system. These cells physiologically increase in number in immune response to certain allergies, chronic inflammation and parasitic infections. But are also a significant indicator for the presence of certain malignancies such as chronic myeloproliferative neoplasms and acute myeloid leukemia. In the current manuscript we present a statistically significant correlation between increasing basophilia in primary myelofibrosis (PMF) and the risk for the subsequent development of an acute myeloid leukemia. We retrospectively identified in the fil...
Source: Frontiers in Oncology - September 5, 2019 Category: Cancer & Oncology Source Type: research