Filtered By:
Cancer: Leukemia
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 58 results found since Jan 2013.
Immune Conditions and Childhood Leukemia
Conclusions and Impact: Children with Down syndrome who develop leukemia have increased diabetes risk, likely due to treatment and underlying susceptibility factors. Cancer Epidemiol Biomarkers Prev; 24(2); 454–8. ©2014 AACR.
Source: Cancer Epidemiology Biomarkers and Prevention - February 5, 2015 Category: Cancer & Oncology Authors: Linabery, A. M., Li, W., Roesler, M. A., Spector, L. G., Gamis, A. S., Olshan, A. F., Heerema, N. A., Ross, J. A. Tags: Research Articles Source Type: research
Epigenetics in Pediatrics
Epigenetic mechanisms are external modifications of DNA that cause changes in gene function and are involved in many diseases. Specific examples of pediatric diseases with a known or suspected epigenetic component include Beckwith-Wiedemann syndrome, childhood leukemia, allergies, asthma, fetal alcohol spectrum disorders, childhood obesity, and type 2 diabetes mellitus. Currently, epigenetically active treatments are being used to treat childhood leukemia. Potential epigenetically active treatments and preventive regimens are under study for other diseases. Pediatricians need to be aware of the epigenetic basis of disease ...
Source: Pediatrics in Review - January 1, 2015 Category: Pediatrics Authors: Puumala, S. E., Hoyme, H. E. Tags: Genetics Articles Source Type: research
Prediagnostic immunoglobulin E levels and risk of chronic lymphocytic leukemia, other lymphomas and multiple myeloma-results of the European Prospective Investigation into Cancer and Nutrition
We examined the association between prediagnostic total (low: <20; intermediate: 20–100; high >100 kU/l) and specific IgE (negative: <0.35; positive ≥0.35 kU/I) concentrations against inhalant antigens and lymphoma risk in a study nested within the European Prospective Investigation into Cancer and Nutrition cohort. A total of 1021 incident cases and matched controls of NHL, multiple myeloma (MM) and Hodgkin lymphoma with a mean follow-up time of 7 years were investigated. Multivariate-adjusted odds ratios (ORs) with 95% confidence intervals (CI) were calculated by conditional logistic regression. Specifi...
Source: Carcinogenesis - November 29, 2014 Category: Cancer & Oncology Authors: Nieters, A., Łuczyłska, A., Becker, S., Becker, N., Vermeulen, R., Overvad, K., Aleksandrova, K., Boeing, H., Lagiou, P., Trichopoulos, D., Trichopoulou, A., Krogh, V., Masala, G., Panico, S., Tumino, R., Sacerdote, C., Bueno-de-Mesquita, B. Tags: Original Manuscript Source Type: research
HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies
Asparaginase is a therapeutic enzyme used to treat leukemia and lymphoma, with immune responses resulting in suboptimal drug exposure and a greater risk of relapse. To elucidate whether there is a genetic component to the mechanism of asparaginase-induced immune responses, we imputed human leukocyte antigen (HLA) alleles in patients of European ancestry enrolled on leukemia trials at St. Jude Children’s Research Hospital (n = 541) and the Children’s Oncology Group (n = 1329). We identified a higher incidence of hypersensitivity and anti-asparaginase antibodies in patients with HLA-DRB1*07:01 alleles (P = 7.5 x ...
Source: Blood - August 21, 2014 Category: Hematology Authors: Fernandez, C. A., Smith, C., Yang, W., Date, M., Bashford, D., Larsen, E., Bowman, W. P., Liu, C., Ramsey, L. B., Chang, T., Turner, V., Loh, M. L., Raetz, E. A., Winick, N. J., Hunger, S. P., Carroll, W. L., Onengut-Gumuscu, S., Chen, W.-M., Concannon, P Tags: Pediatric Hematology, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
Epidemiology of MPN: What Do We Know?
Abstract
The myeloproliferative neoplasms, are characterised by overproduction of myeloid cells. Chronic myeloid leukaemia, polycythaemia vera, essential thrombocythaemia, myelofibrosis and the very rare disorders chronic neutrophilic leukaemia, chronic eosinophilic leukaemia not otherwise specified and mastocytosis are all included in the group. Incidence and prevalence rates reported in the worldwide literature are presented in this review. Survival data on each condition is described. Information on the aetiology of the disorders is discussed including body mass index, diet, smoking and alcohol, allergies, asso...
Source: Current Hematologic Malignancy Reports - August 17, 2014 Category: Hematology Source Type: research
Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia.
Conclusions:This finding might have implication for treatment individualization in ALL and other cancers employing asparagine depletion strategies.
PMID: 24907114 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - June 6, 2014 Category: Cancer & Oncology Authors: Ben Tanfous M, Sharif-Askari B, Ceppi F, Laaribi H, Gagné V, Rousseau J, Labuda M, Silverman LB, Sallan SE, Neuberg D, Kutok JL, Sinnett D, Laverdière C, Krajinovic M Tags: Clin Cancer Res Source Type: research
A prospective study on drug monitoring of PEGasparaginase and Erwinia asparaginase and asparaginase antibodies in pediatric acute lymphoblastic leukemia
This study prospectively analyzed the efficacy of very prolonged courses of pegylated Escherichia coli asparaginase (PEGasparaginase) and Erwinia asparaginase in pediatric acute lymphoblastic leukemia (ALL) patients. Patients received 15 PEGasparaginase infusions (2500 IU/m2 every 2 weeks) in intensification after receiving native E coli asparaginase in induction. In case of allergy to or silent inactivation of PEGasparaginase, Erwinia asparaginase (20 000 IU/m2 2-3 times weekly) was given. Eighty-nine patients were enrolled in the PEGasparaginase study. Twenty (22%) of the PEGasparaginase–treated patients developed ...
Source: Blood - March 27, 2014 Category: Hematology Authors: Tong, W. H., Pieters, R., Kaspers, G. J. L., te Loo, D. M. W. M., Bierings, M. B., van den Bos, C., Kollen, W. J. W., Hop, W. C. J., Lanvers-Kaminsky, C., Relling, M. V., Tissing, W. J. E., van der Sluis, I. M. Tags: Pediatric Hematology, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
Development of a rice-based peptide vaccine for Japanese cedar and cypress pollen allergies.
Abstract
Peptide immunotherapy using dominant T-cell epitopes is a safe treatment alternative to conventional subcutaneous injection of natural crude allergen extract, which is sometimes accompanied by anaphylactic shock. For Japanese cedar pollinosis (JCP), hybrid peptides composed of six to seven major T-cell epitopes (7Crp peptide) from the causative allergens Cry j 1 and Cry j 2 have been developed on the basis of different human leukemia antigen class II restrictions, because of the diversity of patients' genetic backgrounds. However, other dominant T-cell epitopes that are produced in some patients are not c...
Source: Transgenic Research - March 18, 2014 Category: Genetics & Stem Cells Authors: Takaiwa F, Yang L Tags: Transgenic Res Source Type: research
Red Gram (Cajanus cajan) Proteins Induce Hypersensitivity in BALB/c Mice following Oral Exposure and Cause Mediators Release from RBL-2H3 Cells.
Abstract
The prevalence of food allergy is an increasing health concern throughout the world. Among different types of food responsible for causing allergies, legumes contribute a major proportion. Lack of in depth mechanistic information on the allergenic potential through oral route of several leguminous food crops especially Red gram (Cajanus cajan) led to this work. Allergenic potential of red gram crude protein extract was evaluated in BALB/c mice following oral exposure to explore clinical symptoms, thymic stromal lymphopoitin (TSLP), mouse mast cell protease-1 (mMCPT-1) and histamine levels. Also, Rat Basop...
Source: Inflammation and Allergy Drug Targets - January 31, 2014 Category: Allergy & Immunology Authors: Kumar S, Misra A, Verma AK, Sharma A, Das M, Dwivedi PD Tags: Inflamm Allergy Drug Targets Source Type: research
Life-saving transplant results in end to peanut allergy
Not only can bone marrow transplants be life-saving for children with acute lymphocytic leukemia, they may also cure peanut allergies. According to research presented during the American College of Allergy, Asthma and Immunology's (ACAAI) Annual Scientific Meeting, a 10-year-old boy no longer had a peanut allergy after undergoing a bone marrow transplant. "It has been reported that bone marrow and liver transplants can transfer peanut allergy from donor to recipient," said allergist Yong Luo, MD, Ph.D., ACAAI member and lead study author...
Source: Health News from Medical News Today - November 12, 2013 Category: Consumer Health News Tags: Allergy Source Type: news
The great disappearing act: Bone marrow receiver cured of allergy
(American College of Allergy, Asthma, and Immunology) Not only can bone marrow transplants be life-saving for children with acute lymphocytic leukemia, they may also cure peanut allergies. According to research presented during the American College of Allergy, Asthma and Immunology's Annual Scientific Meeting, a 10-year-old boy no longer had a peanut allergy after undergoing a bone marrow transplant.
Source: EurekAlert! - Medicine and Health - November 8, 2013 Category: Global & Universal Source Type: news
Reply: Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter-Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – A reality or myth or two viewpoints about the association between allergies and acute leukaemia in Down syndrome children
Reply: Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter-Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – A reality or myth or two viewpoints about the association between allergies and acute leukaemia in Down syndrome children
British Journal of Cancer advance online publication, August 1 2013.
doi:10.1038/bjc.2013.436
Authors: J C Núñez-Enríquez, A Fajardo-Gutiérrez, E P Buchán-Durán, E Jiménez-Hernández
& J M Mejía-Aranguré
Source: British Journal of Cancer AOP - August 1, 2013 Category: Cancer & Oncology Authors: J C Núñez-EnríquezA Fajardo-GutiérrezE P Buchán-DuránE Jiménez-HernándezJ M Mejía-Aranguré Source Type: research
Loeffler's endocarditis caused by Strongyloides infection
We report a case of a patient who is presented with severe congestive cardiac failure symptoms secondary to Loeffler's endocarditis associated with Strongyloides infection.
Source: International Journal of Cardiology - October 18, 2012 Category: Cardiology Authors: Mark T. Nolan, Fateh Ali Tipoo Sultan, Andrew D. McGavigan, Joseph B. Selvanayagam, Majo X. Joseph Tags: Online Letters to the Editor Source Type: research
