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Total 58 results found since Jan 2013.

Allergic‐like reactions to asparaginase: Atypical allergies without asparaginase inactivation
ConclusionsIn conclusion, allergic‐like reactions occur relatively late after the start of infusion and without antibodies. Despite these clinical differences, allergic‐like reactions can only be distinguished from real allergies by continually measuring asparaginase activity levels. If clinically tolerated, formulations should not be switched in case of allergic‐like reactions. Moreover, failure to recognize these reactions may lead to a less favorable prognosis if asparaginase therapy is terminated unnecessarily.
Source: Pediatric Blood and Cancer - July 4, 2016 Category: Cancer & Oncology Authors: Robin Q. H. Kloos, Rob Pieters, Gabriele Escherich, Inge M. der Sluis Tags: Research Article Source Type: research

Allergic ‐like reactions to asparaginase: Atypical allergies without asparaginase inactivation
ConclusionsIn conclusion, allergic‐like reactions occur relatively late after the start of infusion and without antibodies. Despite these clinical differences, allergic‐like reactions can only be distinguished from real allergies by continually measuring asparaginase activity levels. If clinically tolerated, formulations should not be switched in case of allergic‐like reactions. Moreover, failure to recognize these reactions may lead to a less favorable prognosis if asparaginase therapy is terminated unnecessarily.
Source: Pediatric Blood and Cancer - July 3, 2016 Category: Cancer & Oncology Authors: Robin Q. H. Kloos, Rob Pieters, Gabriele Escherich, Inge M. der Sluis Tags: Research Article Source Type: research

Development of a rice-based peptide vaccine for Japanese cedar and cypress pollen allergies.
Abstract Peptide immunotherapy using dominant T-cell epitopes is a safe treatment alternative to conventional subcutaneous injection of natural crude allergen extract, which is sometimes accompanied by anaphylactic shock. For Japanese cedar pollinosis (JCP), hybrid peptides composed of six to seven major T-cell epitopes (7Crp peptide) from the causative allergens Cry j 1 and Cry j 2 have been developed on the basis of different human leukemia antigen class II restrictions, because of the diversity of patients' genetic backgrounds. However, other dominant T-cell epitopes that are produced in some patients are not c...
Source: Transgenic Research - March 18, 2014 Category: Genetics & Stem Cells Authors: Takaiwa F, Yang L Tags: Transgenic Res Source Type: research

Reply: Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter-Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – A reality or myth or two viewpoints about the association between allergies and acute leukaemia in Down syndrome children
Reply: Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter-Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – A reality or myth or two viewpoints about the association between allergies and acute leukaemia in Down syndrome children British Journal of Cancer advance online publication, August 1 2013. doi:10.1038/bjc.2013.436 Authors: J C Núñez-Enríquez, A Fajardo-Gutiérrez, E P Buchán-Durán, E Jiménez-Hernández & J M Mejía-Aranguré
Source: British Journal of Cancer AOP - August 1, 2013 Category: Cancer & Oncology Authors: J C Núñez-EnríquezA Fajardo-GutiérrezE P Buchán-DuránE Jiménez-HernándezJ M Mejía-Aranguré Source Type: research

Allergies and Risk of NHL in the Agricultural Health Study
Conclusions: Both the reduced risk of NHL among those with allergy symptoms and specific farm exposures in adulthood, and the increased risk among those who grew up on a farm suggest that the host immune response to agricultural allergens may influence NHL development. Impact: This prospective study is, to our knowledge, the first to investigate the relationship between allergy symptoms and NHL risk in farmers; confirmation of these findings in other farming populations is warranted. Cancer Epidemiol Biomarkers Prev; 24(3); 587–94. ©2015 AACR.
Source: Cancer Epidemiology Biomarkers and Prevention - March 5, 2015 Category: Cancer & Oncology Authors: Hofmann, J. N., Hoppin, J. A., Lynch, C. F., Poole, J. A., Purdue, M. P., Blair, A., Alavanja, M. C., Beane Freeman, L. E. Tags: Research Articles Source Type: research

Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia.
Conclusions:This finding might have implication for treatment individualization in ALL and other cancers employing asparagine depletion strategies. PMID: 24907114 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - June 6, 2014 Category: Cancer & Oncology Authors: Ben Tanfous M, Sharif-Askari B, Ceppi F, Laaribi H, Gagné V, Rousseau J, Labuda M, Silverman LB, Sallan SE, Neuberg D, Kutok JL, Sinnett D, Laverdière C, Krajinovic M Tags: Clin Cancer Res Source Type: research

Cesarean Section and Chronic Immune Disorders
This study analyzed the potential association of delivery by cesarean delivery with immune disorders to investigate the potential influence cesarean deliveries could have on development of such conditions. Data from registries in Denmark were used to identify children born between 1977 and 2012. Data were collected on mode of delivery as well as other variables, and the association with several immune diseases was analyzed. The data set included 2 million children over that 35-year period. Nine diseases and 8 confounders were analyzed. The effects of cesarean versus vaginal birth were investigated, and all data were analyz...
Source: Obstetrical and Gynecological Survey - May 1, 2015 Category: OBGYN Tags: Obstetrics: Newborn Medicine Source Type: research

Abstract PR03: Association of environmental risk factors, family history, and polygenic risk scores with chronic lymphocytic leukemia
Conclusions: We found evidence of independent effects among the genetic and non-genetic factors with risk of CLL. Among these factors, the PRS had the largest effect size. Although we did not observe any statistical interactions, larger sample sizes are warranted to fully evaluate these effects on risk of CLL. We are currently increasing our sample size through collaboration with other research groups. Final results will be presented in the meeting.This abstract is also being presented as Poster A06.Citation Format: Geffen Kleinstern, Dennis Robinson, Tim G. Call, Mark Liebow, Silvia de Sanjosé, Yolanda Benavente, J...
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Kleinstern, G., Robinson, D., Call, T. G., Liebow, M., Sanjose, S. d., Benavente, Y., Cerhan, J. R., Slager, S. L. Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Proffered Abstracts Source Type: research

New cancer drug can prevent reactions to common airborne allergens
(Northwestern University) A cancer drug for patients with certain types of leukemia and lymphoma can also prevent reactions to some of the most common airborne allergies, according to a recent Northwestern Medicine study. The promising data from this pilot study could have greater implications for adults with food allergies.
Source: EurekAlert! - Medicine and Health - May 22, 2017 Category: International Medicine & Public Health Source Type: news

Structure –activity relationships of flavanones, flavanone glycosides, and flavones in anti-degranulation activity in rat basophilic leukemia RBL-2H3 cells
AbstractThe incidence of type I allergies, which are associated with mast cell degranulation and local inflammation, is increasing, and new treatments are needed. To date, structure –activity relationships of flavonoids in their degranulation-inhibiting activity have not been systematically characterized. In the current study, the degranulation-inhibiting activity of a series of flavonoids was evaluated. The following three observations were made: (1) the activity disappears when a sugar moiety is introduced into the A ring of the flavanone; (2) the activity depends on the number of hydroxyl groups on the B ring; (3) the...
Source: Journal of Natural Medicines - January 18, 2018 Category: Drugs & Pharmacology Source Type: research

Safety, Efficacy, and Clinical Impact of Penicillin Skin Testing in Immunocompromised Cancer Patients
ConclusionOur findings support PST use in immunocompromised hosts. The widespread use of PST in patients with cancer will allow for optimal use of antimicrobial therapy and stewardship, which are vital in a population at increased risk for infections.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 28, 2019 Category: Allergy & Immunology Source Type: research

Plasma cell gingivitis due to cosmetics related iodopropynyl butylcarbamate (ipbc) allergy in a teenage female patient masking as desquamative gingivitis.
We present a case of PCG in a 13 year old female patient which clinically presented as generalized desquamative gingivitis involving the facial aspects of the attached and marginal gingiva that persisted despite substituting to a non flavored dentifrice and failure to elicit any suspected drug or food allergies. Dermatologic patch testing proved positive for Iodopropynyl Butylcarbamate (IPBC), a water based preservative or biocide used in personal care products. Microscopically, there was an intense inflammatory infiltrate in the lamina propria composed predominantly of mature plasma cells. Immunohistochemistry and in situ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - June 13, 2019 Category: ENT & OMF Source Type: research

Loeffler's endocarditis caused by Strongyloides infection
We report a case of a patient who is presented with severe congestive cardiac failure symptoms secondary to Loeffler's endocarditis associated with Strongyloides infection.
Source: International Journal of Cardiology - October 18, 2012 Category: Cardiology Authors: Mark T. Nolan, Fateh Ali Tipoo Sultan, Andrew D. McGavigan, Joseph B. Selvanayagam, Majo X. Joseph Tags: Online Letters to the Editor Source Type: research

The great disappearing act: Bone marrow receiver cured of allergy
(American College of Allergy, Asthma, and Immunology) Not only can bone marrow transplants be life-saving for children with acute lymphocytic leukemia, they may also cure peanut allergies. According to research presented during the American College of Allergy, Asthma and Immunology's Annual Scientific Meeting, a 10-year-old boy no longer had a peanut allergy after undergoing a bone marrow transplant.
Source: EurekAlert! - Medicine and Health - November 8, 2013 Category: Global & Universal Source Type: news

Life-saving transplant results in end to peanut allergy
Not only can bone marrow transplants be life-saving for children with acute lymphocytic leukemia, they may also cure peanut allergies. According to research presented during the American College of Allergy, Asthma and Immunology's (ACAAI) Annual Scientific Meeting, a 10-year-old boy no longer had a peanut allergy after undergoing a bone marrow transplant. "It has been reported that bone marrow and liver transplants can transfer peanut allergy from donor to recipient," said allergist Yong Luo, MD, Ph.D., ACAAI member and lead study author...
Source: Health News from Medical News Today - November 12, 2013 Category: Consumer Health News Tags: Allergy Source Type: news