Allergic ‐like reactions to asparaginase: Atypical allergies without asparaginase inactivation

ConclusionsIn conclusion, allergic‐like reactions occur relatively late after the start of infusion and without antibodies. Despite these clinical differences, allergic‐like reactions can only be distinguished from real allergies by continually measuring asparaginase activity levels. If clinically tolerated, formulations should not be switched in case of allergic‐like reactions. Moreover, failure to recognize these reactions may lead to a less favorable prognosis if asparaginase therapy is terminated unnecessarily.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research