Rapidly ulcerated swelling in the hard palate of a HIV-positive pregnant woman
Publication date: Available online 13 February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Lucas Lacerda de Souza, Thayná Melo de Lima Morais, Hélder Antônio Rebelo Pontes, Oslei Paes de Almeida, Maria Goretti Freire de Carvalho, Ciro Dantas Soares (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 14, 2020 Category: ENT & OMF Source Type: research

Distribution of metal artifacts arising from the exomass in small field-of-view cone beam computed tomography scans
ConclusionsThe distribution of metal artifacts from the exomass follows the inherent gray value dispersion of CBCT images, with greater inhomogeneity in the inner zone of the FOV. This is exacerbated when metal objects are in the exomass. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 12, 2020 Category: ENT & OMF Source Type: research

Predictors of symptomatic oral lichen planus
ConclusionsMost patients with OLP in the present cohort were symptomatic at the initial visit, with location, type, sex, steroid use and medical conditions being predictors of symptomatic OLP. Despite improvement in OLP symptoms in most patients over time, 25% of patients who are asymptomatic at the initial visit present with symptomatic OLP at a future visit. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 8, 2020 Category: ENT & OMF Source Type: research

A new look at quality assurance in oral and maxillofacial radiology
Publication date: Available online 7 February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): James R. Geist (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 7, 2020 Category: ENT & OMF Source Type: research

A review of the molecular profile of benign and malignant odontogenic lesions
This article summarizes and discusses studies using small, medium, and large-scale and/or “-omic” techniques to describe the molecular characteristics of benign and malignant odontogenic lesions and briefly debates strategies to increase the use of “-omic” and multi-omic approaches or integrative analyses in the research of these lesions. A comprehensive understanding of the molecular aspects of odontogenic lesions by using large-scale approaches will enable us to refine the classification of this heterogeneous group of disorders and provide more accurate biomarkers for precise diagnosis, prognosis,...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 6, 2020 Category: ENT & OMF Source Type: research

Primary pseudomyogenic hemangioendothelioma of right maxilla: a case with immunohistochemistry and FOSB rearrangement study
ConclusionsTo the best of our knowledge, this case represents the first report of PMH arising in the maxilla. The distinct morphologic features, immunophenotypes, and FOSB rearrangement could help achieve precise diagnosis and prevent misdiagnosis of mimics with overlapping features. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 6, 2020 Category: ENT & OMF Source Type: research

Oral manifestations and clinical progression of a rare double-hit B-cell lymphoma: a case report and review of the literature
Publication date: Available online 5 February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Wenli Yu, Chan Park, Benjamin ShimelDouble-hit (DH) lymphoma is a rare subtype of B-cell lymphoma characterized by the chromosomal rearrangement of c-Myc and Bcl-2, and/or Bcl-6. c-Myc is an oncogene that keeps cells proliferative. Bcl-2 and Bcl-6 grant cells antiapoptotic features. The concurrent expression of these genes and their synergistic effect make DH lymphoma refractory to traditional chemotherapy, with an extremely poor prognosis. Here, we present a case of DH lymphoma in the oral cav...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 6, 2020 Category: ENT & OMF Source Type: research

The impact of peritumoral depapillation in cancers of the tongue
ConclusionsLocal invasion and inflammation results in papilla dysfunction clinically appearing as depapillation, leading to accumulation of neurotransmitters and a favorable environment for neural infiltration. We suggest peritumoral depapillation to be a clinical surrogate for perineural invasion, especially in early tongue cancers. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 6, 2020 Category: ENT & OMF Source Type: research

Fractal and radiomorphometric analysis of mandibular bone changes in patients undergoing intravenous corticosteroid therapy
Publication date: Available online 4 February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Ceren Aktuna Belgin, Gozde SerindereObjectiveTo evaluate mandibular bone changes by comparing the fractal dimension (FD), mandibular cortical width (MCW), and panoramic mandibular index (PMI) on panoramic radiographs in patients using intravenous corticosteroids versus controls.Study DesignIn total, 60 patients were divided into 2 groups: 30 patients receiving intravenous corticosteroid treatment and 30 age- and sex-matched healthy people as the control group. Panoramic radiographs of all patie...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 5, 2020 Category: ENT & OMF Source Type: research

Magnetic resonance diffusion weighted imaging using constrained spherical deconvolution-based tractography of the extracranial course of the facial nerve
ConclusionsOur results indicated the potential for accurate 3-dimensional visualization of the extracranial course of the facial nerve, which could have diagnostic implications in differentiating benign from malignant tumors and, crucially, neural involvement. Preoperative planning applications of DWI could help in planning surgical approaches and providing focused counseling. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - February 5, 2020 Category: ENT & OMF Source Type: research

Table of Contents
Publication date: February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 2Author(s): (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 30, 2020 Category: ENT & OMF Source Type: research

Editorial Board
Publication date: February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 2Author(s): (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 30, 2020 Category: ENT & OMF Source Type: research

Society Page
Publication date: February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 2Author(s): (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 30, 2020 Category: ENT & OMF Source Type: research

Information for Readers
Publication date: February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 2Author(s): (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 30, 2020 Category: ENT & OMF Source Type: research

Extracapsular dissection via sternocleidomastoid muscle–parotid space approach—a new operative technique for treating clinically benign tumor in the parotid tail
Publication date: February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 2Author(s): Rong Yang, Yuxing Guo, Chi Mao, Chuanbin Guo, Diancan WangObjectiveThe aim of this study was to introduce extracapsular dissection via the sternocleidomastoid muscle–parotid space approach (ECD-SMPSA) as a modified operative technique for removal of clinically benign tumors from the parotid tail.Study DesignThe study included 52 patients with clinically benign tumors in the parotid tail, and the patients were divided into 2 groups: one group was treated with ECD-SMPSA and the other with...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 30, 2020 Category: ENT & OMF Source Type: research

Histologic analysis of medication-related osteonecrosis of the jaw compared with antiresorptive-exposed bone and other infectious, inflammatory, and necrotic jaw diseases
This study characterized histologic features of medication-related osteonecrosis of the jaw (MRONJ) through analysis of tissues from patients and healthy individuals.Study DesignBone biopsies were collected from various infectious, inflammatory, and necrotic jaw diseases. Samples were divided into bone exposed to bisphosphonates or denosumab, as well as bisphosphonate-related osteonecrosis of the jaw (BRONJ), denosumab-related osteonecrosis of the jaw (DRONJ), and mixed necrosis, enabling us to identify features of single agent necrosis without influence from previous therapies. Hematoxylin and eosin (H&E), receptor ac...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 30, 2020 Category: ENT & OMF Source Type: research

Expression and clinicopathologic significance of coxsackie–adenovirus receptor in oral squamous cell carcinoma
ConclusionsThis study indicated that CAR expression was upregulated in human OSCC and that patients with OSCC with higher expression of CAR had a lower survival rate. Moreover, CAR expression may be associated with HPV infection. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 30, 2020 Category: ENT & OMF Source Type: research

In reply to the Letter to the Editor concerning “Changes of the condylar position after modified disk repositioning: a retrospective study based on magnetic resonance imaging”
Publication date: February 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 2Author(s): Xuzhuo Chen, Jisi Zheng (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 30, 2020 Category: ENT & OMF Source Type: research

Bleeding risk in thrombocytopenic patients after dental extractions: a retrospective single-center study
Publication date: Available online 27 January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Shaiba Sandhu, Vidya Sankar, Alessandro VillaObjectiveThe aim of the present study was to assess the clinical safety profile of dental extractions in patients with thrombocytopenia and explore the effectiveness of platelet transfusion before dental extractions.Study DesignThis is a retrospective cohort study of patients with moderate to severe (≤100,000/μL) thrombocytopenia who underwent dental extractions in the Oral Medicine and Dentistry Clinic at Brigham and Women's Hospital from 2003...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 28, 2020 Category: ENT & OMF Source Type: research

Geographic tongue severity index: A new and clinical scoring system
ConclusionThe new index, Geographic Tongue Area and Severity Index, provides a better characterization of GT by assessing the severity of lesions in an easy and reliable manner, and it is indicated as a first step for interpreting the condition in clinical routines and clinical trials. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 21, 2020 Category: ENT & OMF Source Type: research

Diffuse palatal swelling
Publication date: Available online 13 January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Alaa F. Bukhari, Britta E. Magnuson, Bhavik Desai, Monika Pilichowska, Mark A. Lerman (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 15, 2020 Category: ENT & OMF Source Type: research

Periodontitis, oral hygiene habits, and risk of upper aerodigestive tract cancers: a case-control study in Maharashtra, India
ConclusionsSevere periodontitis is associated with an elevated risk for UADT cancers, and tobacco chewing strengthens this association in this population. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 12, 2020 Category: ENT & OMF Source Type: research

Large expansile lesion of left posterior mandible
Publication date: Available online 10 January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Danielle Gill, Ricardo Padilla, Tamara Giorgadze, Mariko Suchi, Carolyn Brookes (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - January 11, 2020 Category: ENT & OMF Source Type: research

Effects of cannabidiol, a cannabis sativa constituent, on oral wound healing
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): MARIANA KLEIN, JULIANE DE QUADROS DE BORTOLLI, RUCHIELI LOUREIRO BORGHETTI, LETÍCIA SPINELLI JACOBY, FERNANDA GONÇALVES SALUM, KAREN CHERUBINI, MARIA ANTONIA ZANCANARO DE FIGUEIREDOObjectiveTo evaluate the effect of cannabidiol (CBD) on the healing of rats’ oral wounds.Study DesignTraumatic ulcers were induced in 60 Wistar rats using a 5-mm biopsy punch on the midline of the ventral tongue. Animals received daily intraperitoneal (ip) injections of CBD at doses of 0 (control...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Cancer gene mutation profiling in calcifying epithelial odontogenic tumor
ConclusionsCEOT harbor mutations in the tumor suppressor PTEN and CDKN2A and in the oncogenes JAK3 and MET. As these mutations occurred in only 1 case each, they are probably not driver mutations for these tumors. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Methotrexate metabolism and bilirubin levels as predictors of oral mucositis in pediatric oncologic patients
ConclusionsSerum metabolite concentration of MTX and BB should be monitored as relative predictors of higher OM risk. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Dermoid cysts of the oral cavity: a 48-year-retrospective analysis
ConclusionThis study reinforces the importance of knowledge of the clinical and histopathologic aspects of DCs for the correct diagnosis of these lesions. The clinical and histopathologic data of the DCs in our series are similar to studies in other populations. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Immunoexpression pten in oral epithelial dysplasias and squamous cell carcinoma
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): FILIPE NOBRE CHAVES, THÂMARA MANOELA MARINHO BEZERRA, PAULO GOBERLÂNIO DE BARROS SILVA, FÁBIO WILDSON GURGEL COSTA, ANA PAULA NEGREIROS NUNES ALVES, MÁRIO ROGÉRIO LIMA MOTA, KARUZA MARIA ALVES PEREIRAEpithelial oral dysplasia (OED) is a risk factor for developing subsequent oral squamous cell carcinomas (OSCC). PTEN is a tumor suppressor gene of the PI3K/AKT pathway, which is 1 of the most deregulated pathways in cancer.Objective: To perform immunohistochemical...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Comparison of world health organization and binary grading systems in actinic cheilitis
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): THAMIRIS CASTRO ABRANTES, THAMYRES CAMPOS FONSÊCA, MARIENE DA SILVA MONTEIRO, PAULA HELENA ACCIOLY, MÁRCIA GRILLO CABRAL, ALINE CORRÊA ABRAHÃO, MARIO ROMAÑACHObjectiveTo compare the role of histologic epithelial changes of epithelial dysplasia (ED) in actinic cheilitis (AC) in 2 grading systems: World Health Organization (WHO) and binary (BS).Study DesignCytologic and architectural changes of ED, proposed by WHO, were microscopically evaluated in 26 AC by 2 obs...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Inflammatory infiltrate and tumor budding in lip squamous cell carcinomas
This study aimed to describe the morphologic characteristics of lip squamous cells carcinomas focusing in the invasive front and its association with tumor budding, and the presence of neutrophils and T lymphocytes.Study DesignWe included 43 surgical specimens of lip squamous cells carcinoma and classified them in accordance with a histologic invasive front grading system. Immunohistochemistry was performed for CD66b and CD3 for evaluation of neutrophils and T lymphocytes, respectively, in the invasive front of the tumors. Tumor budding was evidenced by AE1/AE3 staining.ResultsThirty-six (83.7%) tumors were well-differenti...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Study of oral lesions biopsed and diagnosed in stomatology clinic of the university during the period from 2002 to 2017
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): RUTH TRAMONTANI RAMOS, MÔNICA SIMÕES ISRAEL, CARLA RENATA PETILLO DE PINHO, TÚLIO FERNANDES DE SOUZA, KARINNE RODRIGUES ALVES LIMA, MARCELA ASSIS VAZ BATISTA OLIVEIRA, JÚLIA BARBOSA LEITEOur objective was to report the principal biopsied and diagnosed oral lesions in a stomatology clinic in a private university between 2002 and 2017. We have conducted a descriptive study in which the data from the histopathologic reports were analyzed on ExcelT and were compared to e...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

A retrospective analysis of 597 oral vascular anomalies diagnosed in a brazilian population
ConclusionsThese lesions particularities knowledge is important for a correct diagnosis and adequate treatment decision. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Low-level laser therapy application for analgesia of odynophagia caused by head and neck radiotherapy
This study aimed to identify the best anatomic area of cervical region of corpses to propose an extraoral LLLT protocol for treating HPM, as well as to evaluate odynophagia in patients treated at a universitary hospital, in southern Brazil. An anatomic study in corpses was performed selecting the best extraoral site to apply LLLT for treating HPM. Furthermore, statements about extraoral LLLT were reported by patients complaining of odynophagia. The carotid trigone showed to be the best site to perform LLLT. Laser protocol to treat HPM consisted of infrared, 4 J, 100 mW, 4 points along the anterior margin of sternocleidomas...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Enamel renal syndrome: a novel homozygous fam20a founder mutation in 5 new brazilian families
ConclusionsOur results reinforce the distinct orofacial features of ERS, which are the clue for kidney examination and genetic testing. Here we report the largest series of patients with ERS of the same population, and describe, for the first time, a founder mutation for FAM20A gene. FAPEMIG, FAPESP, CAPES. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Histopathologic review of malignant salivary gland tumors
ConclusionsThis study is relevant to obtain epidemiologic data of malignant salivary gland tumors due to few reports from our country. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Prevalence of fungal infections and the oral health of hospitalized patients in a dermatology service
ConclusionsThis study demonstrated that the percentage of patients with dental/oral care needs in a hospital service is high and that the performance of dentist in the hospital environment is essential for the promotion, protection, and recovery of hospitalized patients’ health, reducing the risk of infection caused by opportunistic pathogens and improving the quality of life of these patients. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Intravascular papillary endothelial hyperplasia: a systematic review
ConclusionsThe features presented in this study are more similar to than different from those reported in the literature. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Epidemiologic evaluation of oral lesions biopsied in stomatology service in population of 7 cities
ConclusionsClinical care in the area of stomatology offered to population of 7 cities by the CEO presents fundamental importance in the diagnosis and treatment of oral cavity lesions. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Association between periapical lesions and sinus maxillary alterations using cone beam computed tomography
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): PRISCILA QUINTINO CHABOT, TÂNIA MARA PIMENTA AMARAL, LOLIZA LUIZ FIGUEIREDO HOURI CHALUB, CLÁUDIA BORGES BRASILEIROObjectiveThe aim of this study was to evaluate the relationship between periapical lesion (PL) and maxillary sinus alterations (MSA) using cone beam computed tomography (CBCT).Study DesignCBCT images of a dental radiology service were seen from January 2013 to December 2017 by a single previously calibrated examiner. PL was recorded when at least 1 posterior tooth pre...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Calcification of the stylohyoid ligament: a retrospective study of the year 2017
This study aims to analyze the incidence of calcification of the stylohyoid ligament through panoramic radiographs, considering its importance in clinical routine. Five hundred digitalized panoramic radiographs taken in 2017 were analyzed considering the incidence of the calcification of the stylohyoid ligament. The material was classified according to age, sex, and the affected side. According to the analysis, it was possible to identify a high frequency of calcifications (88%). It was observed that patients aged between 21 and 30 years old were the most affected ones (32.2%). Despite its probability, no significant diffe...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

First detection of dengue virus in the saliva of immunocompetent murine model
ConclusionsThis study reports the first DENV detection in saliva of BALB/c immunocompetent mice experimentally infected with nonneuroadapted DENV-4. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Comparison of prognostic factors of oral squamous cell carcinoma between young and older patients: a systematic review
ConclusionsAmong all prognostic factors evaluated, survival showed difference in age groups, suggesting, then, that OSCC in older patients could exhibit more aggressive biologic behavior. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Effects of caffeic acid phenethyl ester on the expression of interleukins 6 and 8 in oral squamous cell carcinoma
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): LEONARDO RINALDI, LEOPOLDO LUIZ ROCHA FUJII, LUCAS NOVAES TEIXEIRAObjectiveThe present study evaluated the effects of caffeic acid phenethyl ester (CAPE) on cell viability and expression of interleukins (IL-) 6 and 8 in oral squamous cell carcinoma cell cultures (CAL-27).Study DesignCAL-27 cells were plated at the density of 3500 cells/well in 96-well plates and exposed to CAPE at concentrations of 0, 25, 50, 100, and 200 μM. After 24, 48, and 72 hours, the following parameters were evaluat...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Expression of cancer stem cells surface markers in tongue squamous cell carcinoma cell lines
Conclusions: The 2 OSCC cell lines presented distinct patterns of cancer stem cells surface markers. Further experiments will be needed to better characterize the CSCs populations present in SCC9 and SCC9 ZsGreen LN1 cell lines. (FAPESP 14/20832-3). (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Fasn inhibition with tvb-3166 in oral squamous cell carcinoma cell lines
ConclusionsOur preliminary results suggest that fasn inhibition with TVB-3166 affects important processes of tumor progression in cell lines derived from OSCC. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Cd1a+ langerhans cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): LUAN CÉSAR DA SILVA, FELIPE PAIVA FONSECA, OSLEI PAES DE ALMEIDA, MÁRCIO AJUDARTE LOPES, RAGHU RADHAKRISHNAN, LUIZ PAULO KOWALSKI, PABLO AGUSTIN VARGASOral submucous fibrosis (OSMF) affects mainly the Indian subcontinent and its manifestations are closely linked with the habit of chewing betel. Immune system cells such as Langerhans cells (LC) and dendritic cells (DC) are linked to the immunopathogenesis of various lesions and have been studied for their ability of recognizing pr...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Study of immunohistochemical expression of rankl, opg, il-6, and ctsk in odontogenic cysts and tumors
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): FERNANDA MARCELLO SCOTTI, DIOGO LENZI CAPELLA, DANIELLA SERAFIN COUTO VIEIRA, ELENA RIET CORREA RIVEROObjectiveTo evaluate the receptor activator of nuclear factor-K B ligand (RANKL), osteoprotegerin (OPG), interleukin-6 (IL-6), and cathepsin K (CTSK) antigens in 34 radicular cysts (RC), 28 odontogenic keratocysts (OKC), and 25 ameloblastomas (AM).Study DesignThe immunohistochemical expression of these proteins was evaluated considering the mean of percentage marked area in 10 consecutive fiel...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Histologic comparative study of bone specimens from bisphosphonate-related osteonecrosis of the jaws and osteomyelitis
Conclusions: Absence of the osteoblast layer is more common in BRONJ samples in comparison with OM samples and can represent differences in the capacity of bone turnover associated with both conditions. The authors thank FAPERJ for the financial support for the study. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Rapamycin on the treatment of mucoepidermoid carcinomas and squamous cell carcinomas
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): LEONARDO AMARAL DOS REIS, RENATA LUCENA MARKMAN, LIANA PRETTO WEBBER, PABLO AGUSTIN VARGAS, JACKS JORGE, CRISTIANE HELENA SQUARIZE, ROGERIO CASTILHOMucoepidermoid carcinomas (MEC) are the most common malignancy of the salivary glands. Dysfunctional clock signaling is observed in a variety of pathologic conditions. Members of the clock gene family are upregulated in tumor cells. We explored the role of the mTOR signaling pathway, commonly found upregulated in tumors including in MEC, oral squam...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Giant cell fibroma: 10-year survey in an oral pathology service
Conclusions: The distribution of GCF in relation to sex and age is similar to the conventional fibroma; however, its preferential location is different. The final differentiation is given by histopathologic analysis. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research