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Total 40 results found since Jan 2013.

Collaboration with Gastroenterology in Management of Complex Dysphagia
AbstractPurpose of ReviewTo review common patient populations who present with dysphagia to an otolaryngology office and that may benefit from co-management with a gastroenterologist. These patients include those with gastroesophageal reflux disease, head and neck cancer, allergies/atopic disease, autoimmune conditions, and a normal/straightforward workup for dysphagia.Recent FindingsThe additional diagnostic tests that can be offered by a gastroenterologist beyond an upper endoscopy include high-resolution manometry, functional luminal imaging probe, and mucosal impedance testing. Pharmacologic therapies, as well as endos...
Source: Current Otorhinolaryngology Reports - August 15, 2023 Category: ENT & OMF Source Type: research

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, direct oral penicillin challenge in patients with a low-risk penicillin allergy was noninferior compared with standard-of-care skin testing followed by oral challenge. In patients with a low-risk history, direct oral penicillin challenge is a safe procedure to facilitate the removal of a penicillin allergy label.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04454229.PMID:37459086 | DOI:10.1001/jamainternmed.2023.2986
Source: Cancer Control - July 17, 2023 Category: Cancer & Oncology Authors: Ana Maria Copaescu Sara Vogrin Fiona James Kyra Y L Chua Morgan T Rose Joseph De Luca Jamie Waldron Andrew Awad Jack Godsell Elise Mitri Belinda Lambros Abby Douglas Rabea Youcef Khoudja Ghislaine A C Isabwe Genevieve Genest Michael Fein Cristine Radojici Source Type: research

520 A retrospective cohort study of patch testing in oral lichen planus and subsequent diagnosis of oral squamous cell carcinoma
Oral lichen planus (OLP) is a recalcitrant, relapsing autoimmune condition that poses a significant treatment challenge. Allergies to dental metals, fragrances, and additives have been documented in the setting of OLP. Likewise, oral squamous cell carcinoma (OSCC) has been reported to evolve in lesions of OLP. We hypothesized that the chronic inflammation of allergy-driven OLP may increase the odds of developing OSCC. Our primary objective was to compare the odds of OSCC between patch test negative and positive patients.
Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: V.N. Sahni, Z. Hopkins, J. Rhoads, J. Clarke, C. Hansen, D. Powell, R. deShazo, J. Zone, C. Hull Source Type: research

Continuous ingestion of sodium chloride solution promotes allergen absorption and may exacerbate allergy symptoms on ovalbumin-induced food allergy in mice
In this study, we investigated the effect of continuous ingestion of sodium chloride (NaCl) on allergy symptoms using a mouse model of food allergy. BALB/c mice were divided into four groups of 6-8 animals each. The control-water group (CW) and sensitization-water group (SW) groups were provided free access to water, and the control-1% NaCl group (CS) and sensitization-1% NaCl group (SS) groups were provided a 1% NaCl solution. The SW and SS groups were sensitized with 50 µg ovalbumin (OVA) at 2 timepoints by intraperitoneal injection. After oral administration of OVA, anaphylactic response was measured and blood was coll...
Source: Drug Discoveries and Therapeutics - February 27, 2023 Category: Drugs & Pharmacology Authors: Mamoru Tanaka Rui Lu Hana Kozai Source Type: research

Inpatient Direct Oral Penicillin Challenge – A Large Prospective Cohort Study
Penicillin allergies are associated with inferior patient and antimicrobial stewardship outcomes. The long-term implementation (3.5 years) of a whole-of-hospital program to assess the safety of inpatient delabeling by direct oral challenge for low-risk penicillin allergies in hospitalized inpatients at Austin Hospital and the Peter MacCallum Cancer Centre, Australia was described here.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Kyra Chua, Sara Vogrin, Jamie Waldron, Elise Mitri, Rebecca Hall, Ana Maria Copaescu, Natasha Holmes, Jason Trubiano Source Type: research

Cell-penetrating albumin enhances the sublingual delivery of antigens through macropinocytosis
Int J Biol Macromol. 2022 Sep 17:S0141-8130(22)02063-3. doi: 10.1016/j.ijbiomac.2022.09.132. Online ahead of print.ABSTRACTInnovations in oral immunotherapy have greatly advanced the therapeutic control of allergies. However, these therapeutic effects suffer from the fact that the amount of antigen delivered to antigen-presenting cells is limited given the formulations that are currently available. We recently designed a cell-penetrating albumin and found that this modified albumin enters cells via the induction of macropinocytosis. Herein, we report on a novel system for delivering antigens based on cell-penetrating album...
Source: International Journal of Biological Macromolecules - September 20, 2022 Category: Biochemistry Authors: Hitoshi Maeda Shota Ichimizu Hiroshi Watanabe Keisuke Hamasaki Mayuko Chikamatsu Ryota Murata Nao Yumoto Takahiro Seki Hiroshi Katsuki Masaki Otagiri Toru Maruyama Source Type: research

What Are Some Indications for Using Dexamethasone?
Discussion Corticosteroids are a group of drugs which can be naturally or synthetically produced. Naturally occurring substances are produced in the adrenal gland, and are protein-bound (primarily corticosteroid-binding globulin and albumin). In the target tissues, they may need to be converted to an active substance. They are then reduced, oxidized, hydroxylated or conjugated as measures to inactivate them. Synthetic steroids have less protein binding and depending on their structure are more or less resistant to inactivation. Prednisone is the glucocorticoid most often used for treatment, especially as it has a short hal...
Source: PediatricEducation.org - June 7, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

The Epigenetics of Food Allergy.
Authors: Chang C, Wu H, Lu Q Abstract Food allergy is a global health problem, particularly in developed countries. It is mainly mediated by Th2 cell and IgE produced by B cells. While the pathogenesis of IgE-mediated food allergy is quite straightforward, the factors that lead to the development of food allergies at any age in children and adults are unclear. Recent studies have revealed that genetics, epigenetics, and environmental exposures contribute to the development of atopy. In this chapter, we discuss the interplay between these three key elements, reveal how epigenetic modifications may mediate genetic su...
Source: Advances in Experimental Medicine and Biology - May 25, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment
Food allergy is rising at an alarming rate and is a major public health concern. Globally, food allergy affects over 500 million people, often starting in early childhood and increasingly reported in adults. Commercially, only one approved oral immunotherapy-based treatment is currently available and other allergen-based immunotherapeutic are being investigated in clinical studies. As an alternative approach, a substantial amount of research has been conducted on natural compounds and probiotics, focusing on the immune modes of action, and therapeutic uses of such sources to tackle various immune-related diseases. Food all...
Source: Frontiers in Immunology - May 21, 2020 Category: Allergy & Immunology Source Type: research

Pharmacological action and potential targets of chlorogenic acid.
Abstract Chlorogenic acid is a widely distributed natural compound with many important pharmacological effects, which are found in a variety of plants. It is also an important secondary metabolite in plants. As a natural plant extract from a wide range of sources, in vitro and in vivo studies have found that the main pharmacological effects of chlorogenic acid are antioxidant, antiinflammatory, antibacterial, antiviral, hypoglycemic, lipid lowering, anticardiovascular, antimutagenic, anticancer, immunomodulatory, etc. Therefore it may play an important role in promoting human health. For example, it can provide ne...
Source: Advances in Pharmacology - February 26, 2020 Category: Drugs & Pharmacology Authors: Miao M, Xiang L Tags: Adv Pharmacol Source Type: research

Naringenin Suppresses Chemically Induced Skin Cancer in Two-Stage Skin Carcinogenesis Mouse Model.
Conclusion: Naringenin exhibited anti-tumor effect in two stage carcinogenesis mouse skin tumor model. This study revealed that consumption of citrus fruits and the naringenin therein may be helpful in suppression of skin cancer. PMID: 31474152 [PubMed - as supplied by publisher]
Source: Nutrition and Cancer - September 1, 2019 Category: Cancer & Oncology Authors: Kumar R, Bhan Tiku A Tags: Nutr Cancer Source Type: research

Cardioprotective Activity of Agaricus bisporus Against Isoproterenol- Induced Myocardial Infarction in Laboratory Animals
Conclusion: It can be an outcome that EEAB possessed cardioprotective activity against experimental and clinical studies of ISO-induced myocardial infarction in rats.
Source: Current Nutrition and Food Science - June 28, 2019 Category: Nutrition Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research