520 A retrospective cohort study of patch testing in oral lichen planus and subsequent diagnosis of oral squamous cell carcinoma

Oral lichen planus (OLP) is a recalcitrant, relapsing autoimmune condition that poses a significant treatment challenge. Allergies to dental metals, fragrances, and additives have been documented in the setting of OLP. Likewise, oral squamous cell carcinoma (OSCC) has been reported to evolve in lesions of OLP. We hypothesized that the chronic inflammation of allergy-driven OLP may increase the odds of developing OSCC. Our primary objective was to compare the odds of OSCC between patch test negative and positive patients.

Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: V.N. Sahni, Z. Hopkins, J. Rhoads, J. Clarke, C. Hansen, D. Powell, R. deShazo, J. Zone, C. Hull Source Type: research