What Are Some Indications for Using Dexamethasone?

Discussion Corticosteroids are a group of drugs which can be naturally or synthetically produced. Naturally occurring substances are produced in the adrenal gland, and are protein-bound (primarily corticosteroid-binding globulin and albumin). In the target tissues, they may need to be converted to an active substance. They are then reduced, oxidized, hydroxylated or conjugated as measures to inactivate them. Synthetic steroids have less protein binding and depending on their structure are more or less resistant to inactivation. Prednisone is the glucocorticoid most often used for treatment, especially as it has a short half-life. Prednisone must be converted to prednisolone to create any glucocorticoid effect. Asthma, acute severe dermatitis (e.g. poison ivy), chronic dermatitis (e.g. atopic dermatitis) are common uses of it for the primary care provider. Systemic corticosteroids comparison: Short acting Cortisol or hydrocortisone, cortisone acetate Lasts 8-12 hours Anti-inflammatory activity = hydrocortisone is considered the standard Intermediate Prednisone, prednisolone, methylprednisolone, triamcinolone Lasts 12-36 hours Anti-inflammatory activity is increased 4-5 times, therefore an equivalent dose is less than hydrocortisone dosing (specific dosing must be checked) Long acting Betamethasone, dexamethasone Lasts 36-72 hours Anti-inflammatory activity is increased ~30 times, therefore an equivalent dose is substantially less than hydrocortisone dosing (specific do...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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Source: Journal of Toxicology and Environmental Health Part A - Category: Environmental Health Authors: Source Type: research
Authors: Musio F Abstract INTRODUCTION: Anemia has and will continue to be a central theme in medicine particularly as clinicians are treating a burgeoning population of complex multi-organ system processes. As a result of multiple randomized controlled trials (RCTs), meta-analyses, and societal recommendations overly restrictive paradigms and under-administration of erythropoiesis stimulating agents (ESAs) have likely been followed by clinicians among all specialties. AREAS COVERED: A review of anemia in the context of chronic kidney disease, hematologic malignancies and cancer is presented with focus on the e...
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