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Total 71 results found since Jan 2013.

CCL24 Signaling in the Tumor Microenvironment
Adv Exp Med Biol. 2021;1302:91-98. doi: 10.1007/978-3-030-62658-7_7.ABSTRACTChemokines with their network play an important role in cancer growth, metastasis, and host-tumor interactions. Of many chemokines, C-C motif chemokine ligand 24 (CCL24) has been shown to contribute to tumorigenesis as well as inflammatory diseases like asthma, allergies, and eosinophilic esophagitis. CCL24 is expressed in some tumor cells such as colon cancer, hepatocellular carcinoma, and cutaneous T cell lymphoma. CCL24 can be used as a potential biomarker in several cancers including colon cancer, non-small cell cancer, and nasopharyngeal carci...
Source: Advances in Experimental Medicine and Biology - July 21, 2021 Category: Research Authors: Sung-Jig Lim Source Type: research

Characterization of outcomes in patients with advanced genitourinary malignancies treated with immune checkpoint inhibitors.
CONCLUSION: Greater frequency and higher grades of irAEs are associated with better treatment response in patients with RCC and urothelial malignancy receiving ICI therapy. The presence of liver metastases denotes a negative predictive marker for immunotherapy efficacy. SUMMARY: Immune checkpoint inhibitors (ICI) are increasingly used to treat genitourinary (GU) malignancies. However, clinical data regarding patients with advanced-stage GU malignancies treated with ICI is lacking. Thus, we performed a single-center, retrospective cohort study on patients with metastatic and unresectable renal cell carcinoma (RCC) and ...
Source: Urologic Oncology - January 22, 2021 Category: Urology & Nephrology Authors: Ma VT, Su CT, Hu M, Taylor JMG, Daignault-Newton S, Kellezi O, Dahl MN, Shah MA, Erickson S, Lora J, Hamasha R, Ali A, Yancey S, Kiros L, Balicki HM, Winfield DC, Green MD, Alva AS Tags: Urol Oncol Source Type: research

Anticancer effects of Poncirus  fructus on hepatocellular carcinoma through regulation of apoptosis, migration, and invasion.
This study investigated the ability of PF to induce apoptosis and inhibit the invasiveness and migratory ability of HCC cell lines (Hep3B and Huh7). Wound healing, Transwell migration and invasion, and colony‑formation assays, as well as flow cytometry, were used to analyze cell proliferation, migration, invasion, and apoptosis. Epithelial‑mesenchymal transition (EMT)‑related and apoptotic proteins were assessed by western blotting. The mitochondrial membrane potential of the Hep3B and Huh7 cells was observed with tetramethylrhodamine ethyl ester. The reactive oxygen species (ROS) level was determined by dihydroethid...
Source: Oncology Reports - November 1, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Exploring bioactivity potential of polyphenolic water-soluble lignin derivative.
Abstract Many natural substances exhibit anti-inflammatory activity and considerable potential in prophylaxis and treatment of allergies. Knowing exact molecular targets, which is required for developing these as medicinal products, is often challenging for multicomponent compositions. In the present study we examined novel polyphenolic substance, a water-soluble fraction of wood lignin (laboratory code BP-Cx-1). In our previous study, a number of polyphenolic components of BP-Cx-1 (flavonoids, sapogenins, phenanthrenes etc.) were identified as the major carriers of biological activity of BP-Cx drug family, and se...
Source: Environmental Research - September 10, 2020 Category: Environmental Health Authors: Fedoros EI, Baldueva IA, Perminova IV, Badun GA, Chernysheva MG, Grozdova ID, Melik-Nubarov NS, Danilova AB, Nekhaeva TL, Kuznetsova AI, Emelyanova NV, Ryakhovskiy AA, Pigarev SE, Semenov AL, Tyndyk ML, Gubareva EA, Panchenko AV, Bykov VN, Anisimov VN Tags: Environ Res Source Type: research

58P Risk factors for immune related adverse events: A retrospective study
ConclusionThis study helped distinguish potential risk factors for irAE, like the female gender and history of allergies. Autoimmune disorders are already reported as risk factores. However the small sample isn't enough for us to draw accurate conclusions. More prospective trials are waranted in this setting.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - December 15, 2019 Category: Cancer & Oncology Source Type: research

Characterizations and application of CA/ZnO/AgNP composite nanofibers for sustained antibacterial properties
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Abdul Wahab Jatoi, Ick Soo Kim, Hiroshi Ogasawara, Qing-Qing NiAbstractAlthough silver based nanofibers possess excellent bactericidal and bacteriostatic characteristics. However, excess release/contact with silver may induce harmful side-effects including carcinoma, argyria, argyrosis and allergies. Similarly, silver depletion may limit prolonged antibacterial activities as well. Thus present research proposes electrospun CA/ZnO/AgNPs composite nanofibers for biologically safer and sustained antibacterial applications. The Zn...
Source: Materials Science and Engineering: C - August 19, 2019 Category: Materials Science Source Type: research

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Dysphagia: Thinking outside the box.
Abstract Dysphagia is a common symptom that is important to recognise and appropriately manage, given that causes include life threatening oesophageal neoplasia, oropharyngeal dysfunction, the risk of aspiration, as well as chronic disabling gastroesophageal reflux (GORD). The predominant causes of dysphagia varies between cohorts depending on the interplay between genetic predisposition and environmental risk factors, and is changing with time. Currently in white Caucasian societies adopting a western lifestyle, obesity is common and thus associated gastroesophageal reflux disease is increasingly diagnosed. Simil...
Source: World Journal of Gastroenterology - October 14, 2017 Category: Gastroenterology Authors: Philpott H, Garg M, Tomic D, Balasubramanian S, Sweis R Tags: World J Gastroenterol Source Type: research

To distinguish IgG4-related disease from seronegative granulomatosis with polyangiitis
Rheumatology key messageIgG4-related disease might be an alternative diagnosis in limited granulomatosis with polyangiitis. Sir, IgG4-related disease (IgG4-RD) is a fibro-inflammatory disease that can affect almost every organ [1]. Indeed, previous unexplained conditions have now been reclassified as primarily IgG4-RD and may imitate many inflammatory, infectious and malignant disorders often leading to a delay in diagnosis or incorrect diagnosis. Nasal manifestation of IgG4-RD, mostly of the paranasal sinuses, has previously been described in case reports, but it can also manifest as a primary or secondary nasal disease s...
Source: Rheumatology - September 5, 2017 Category: Rheumatology Source Type: research

Association of atopy and tentative diagnosis of skin cancer – results from occupational skin cancer screenings
ConclusionDesign limitations of the study include that all findings of skin cancer were based on clinical examination only and must therefore be considered tentative diagnoses. Furthermore, owing to the cross‐sectional study design, causal pathways cannot be proven. However, analyses of data from such a large and general population‐based cohort afford valuable insights into the relationship between atopic diseases and skin cancer. They provide the grounds for prospective cohort studies to evaluate and dissect the underlying mechanism.
Source: Journal of the European Academy of Dermatology and Venereology - August 3, 2017 Category: Dermatology Authors: I. Sch äfer, P. Mohr, N. Zander, R. Fölster‐Holst, M. Augustin Tags: Original Article Source Type: research

Association of atopy and tentative diagnosis of skin cancer ‐ results from occupational skin cancer screenings
ConclusionDesign limitations of the study include that all findings of skin cancer were based on clinical examination only and must therefore be considered tentative diagnoses. Furthermore, owing to the cross‐sectional study design, causal pathways cannot be proven. However, analyses of data from such a large and general population‐based cohort afford valuable insights into the relationship of atopic diseases and skin cancer. They provide the grounds for prospective cohort studies to evaluate and dissect the underlying mechanism.This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - July 6, 2017 Category: Dermatology Authors: I. Sch äfer, P. Mohr, N. Zander, R. Fölster‐Holst, M. Augustin Tags: Original Article Source Type: research

A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients
Conclusion: Methylene blue performed as well as patent blue in identifying the SLN in breast cancer patients.Resumo Introdu ção: O azul de metileno é mais facilmente encontrado para comercialização e a um preço menor que o azul patente. Parece ainda haver menor risco de anafilaxia. Objetivo: Comparar a taxa de detecção do linfonodo sentinela com o azul patente e com o azul de metileno. Método: Foram incluídas , de forma randomizada e prospectiva, 142 pacientes com diagnóstico de carcinoma mamário invasor, que consentiram em participar livremente do estudo. Foram injetados 2 mL de azul patente (grupo A) em 69 (4...
Source: Revista da Associacao Medica Brasileira - March 24, 2017 Category: Journals (General) Source Type: research

An asymptomatic diffuse palatal mass
An 82-year-old African American woman presented for evaluation of “itchiness and tingling” of the palate and a poorly fitting maxillary denture of 2 months' history. Her medical history was significant for hypertension, hyperlipidemia, atrial fibrillation, gout, gastroesophageal reflux disease, and left breast ductal carcinoma in situ (status—post–excisi on and radiation therapy in 2008). Her medications included diltiazem, pravastatin, allopurinol, colchicine, and omeprazole, and she had no known drug allergies.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - March 16, 2017 Category: ENT & OMF Authors: Ahmed S. Sultan, Sook-Bin Woo Tags: Clinicopathologic conference Source Type: research