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Total 71 results found since Jan 2013.

Allergies and Atopic Dermatitis in Relation to Skin Cancer
Conclusion: Our findings suggest that allergies and atopy may influence risk of early onset BCC and SCC, and that effects may be gender specific. Impact: A deeper understanding of the immune mechanisms underlying allergies and atopy may provide new routes of preventing keratinocyte cancers. Cancer Epidemiol Biomarkers Prev; 24(4); 749–54. ©2015 AACR.
Source: Cancer Epidemiology Biomarkers and Prevention - March 31, 2015 Category: Cancer & Oncology Authors: Cheng, J., Zens, M. S., Duell, E., Perry, A. E., Chapman, M. S., Karagas, M. R. Tags: Research Articles Source Type: research

58P Risk factors for immune related adverse events: A retrospective study
ConclusionThis study helped distinguish potential risk factors for irAE, like the female gender and history of allergies. Autoimmune disorders are already reported as risk factores. However the small sample isn't enough for us to draw accurate conclusions. More prospective trials are waranted in this setting.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - December 15, 2019 Category: Cancer & Oncology Source Type: research

Characterization of outcomes in patients with advanced genitourinary malignancies treated with immune checkpoint inhibitors.
CONCLUSION: Greater frequency and higher grades of irAEs are associated with better treatment response in patients with RCC and urothelial malignancy receiving ICI therapy. The presence of liver metastases denotes a negative predictive marker for immunotherapy efficacy. SUMMARY: Immune checkpoint inhibitors (ICI) are increasingly used to treat genitourinary (GU) malignancies. However, clinical data regarding patients with advanced-stage GU malignancies treated with ICI is lacking. Thus, we performed a single-center, retrospective cohort study on patients with metastatic and unresectable renal cell carcinoma (RCC) and ...
Source: Urologic Oncology - January 22, 2021 Category: Urology & Nephrology Authors: Ma VT, Su CT, Hu M, Taylor JMG, Daignault-Newton S, Kellezi O, Dahl MN, Shah MA, Erickson S, Lora J, Hamasha R, Ali A, Yancey S, Kiros L, Balicki HM, Winfield DC, Green MD, Alva AS Tags: Urol Oncol Source Type: research

Adenocarcinoma of the Stomach and Neuroendocrine Carcinoma of the Colon in a 45-Year-Old Male Patient Suffering from Common Variable Immunodeficiency (CVID) and Ulcerative Colitis.
Abstract Common variable immunodeficiency (CVID) is the most common primary antibody deficient syndrome in adults. Among the broad spectrum of clinical manifestations are recurrent infections, allergies, autoimmune, tumour, pulmonary, liver and gastrointestinal diseases. Here we report the case of a 45-year-old male patient, who has been suffering from ulcerative colitis - likewise recognised as a CVID-associated disease - for many years. He was admitted to our clinic with a rapid progressive reduction of his general condition and a loss of weight. Diagnostic work-up revealed adenocarcinoma of the stomach as well ...
Source: Zeitschrift fur Gastroenterologie - December 1, 2012 Category: Gastroenterology Authors: Gemeinhardt M, Türck J, Piper B, Helmberger T, Nerlich A, Schepp W Tags: Z Gastroenterol Source Type: research

UK cancer treatment: When ‘out of the ordinary’ means ‘out of luck’
Lynne Hazelden is caught in a bureaucratic nightmare – and nothing less than her life is at stake
Source: Alliance for Natural Health - July 17, 2013 Category: Complementary Medicine Authors: Adam Tags: allergies allergy breast cancer carcinoma ductal europe Grade III Hazelden international Lynne Hazelden mercury NHS pathways Source Type: news

Systemic glucocorticoid use and early-onset basal cell carcinoma
Immunosuppressive medications are common in the management of numerous conditions, such as organ transplantation, allergies, and respiratory disorders [1]. In some patients with conditions, such as organ transplantation, that require long-term high-dose immunosuppression, immunosuppressives increase risk for squamous cell carcinoma of the skin (SCC; 60- to 250-fold increase), and to a lesser extent for basal cell carcinoma (BCC; 10-fold increase) [2–10]. An increased risk of nonmelanoma skin cancer (NMSC) has also been associated with immunosuppressives among rheumatoid arthritis and inflammatory bowel disease patients [11–13].
Source: Annals of Epidemiology - May 22, 2014 Category: Epidemiology Authors: Jose Ramon Troche, Leah M. Ferrucci, Brenda Cartmel, David J. Leffell, Allen E. Bale, Susan T. Mayne Tags: Rapid Report Source Type: research

New systemic agents in dermatology with respect to fertility, pregnancy, and lactation
This article presents current knowledge from the sources mentioned above, and gives detailed information about the use of new biologic agents in women wishing to conceive as well as during pregnancy and lactation. Drugs reviewed include: infliximab, adalimumab, etanercept, metastatic for psoriasis, vemurafenib, dabrafenib, imatinib, ipilimumab for melanoma, vismodegib for basal cell carcinoma, rituximab for cutaneous lymphoma as well as omalizumab and anakinra used in the treatment of allergies.
Source: JDDG - March 25, 2015 Category: Dermatology Authors: Sonja Grunewald, Alexander Jank Tags: CME Article Source Type: research

Centipeda minima (Ebushicao) extract inhibits PI3K-Akt-mTOR signaling in nasopharyngeal carcinoma CNE-1 cells
This study aims to investigate the anticancer activities of Centipeda minima ethanol extracts (CME) against nasopharyngeal carcinoma cell CNE-1 and their underlying mechanism. Methods: CNE-1 cells were treated with different concentrations (15–50 μg/mL) of CME for different time intervals (24, 48, and 72 h). Cytotoxicity of CME was determined by MTT assay. Cell morphological changes were observed by fluorescence microscopy after HO 33258 staining. Cell cycle status was evaluated by flow cytometry following propidium iodide staining. Apoptosis was detected by flow cytometry following annexin V-FITC/PI staining. The lev...
Source: Chinese Medicine - September 18, 2015 Category: Complementary Medicine Authors: Yu-qing GuoHai-yan SunChi-on ChanBei-bei LiuJian-hong WuShun-wan ChanDaniel MokAnfernee TseZhi-ling YuSi-bao Chen Source Type: research

Clinical Translation of an Albumin-Binding PET Radiotracer 68Ga-NEB
Conclusion: As a blood-pool imaging agent, 68Ga-NEB is safe to use in the clinic, and our preliminary studies demonstrate the value of differentiating hepatic hemangioma from other benign or malignant focal hepatic lesions. Easy labeling with different positron emitters of various half-lives, excellent pharmacokinetics, and imaging quality warrant further clinical applications of NEB-based PET tracers.
Source: Journal of Nuclear Medicine - October 1, 2015 Category: Nuclear Medicine Authors: Zhang, J., Lang, L., Zhu, Z., Li, F., Niu, G., Chen, X. Tags: Basic Science Investigations Source Type: research

EPMA-World Congress 2015
Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of ...
Source: EPMA Journal - May 8, 2016 Category: Global & Universal Source Type: research

Role of diffusion weighted imaging (DWI) for hepatocellular carcinoma (HCC) detection and its grading on 3T MRI: A prospective study
Conclusion DWI can be used as an alternative for the detection and characterization of HCC, especially in patients with impaired renal function or contrast allergies precluding the use of contrast. In addition, DWI with ADC measurement may be helpful for non-invasive and preoperative prediction of the degree of differentiation of HCC.
Source: Journal of Clinical and Experimental Hepatology - September 1, 2016 Category: Gastroenterology Source Type: research

Pilomatrix Carcinoma Mimicking a Pigmented Basal Cell Carcinoma.
Abstract A 76-year-old Caucasian man presented to the dermatology clinic for evaluation of a growing lesion in his right preauricular area. He first noticed the lesion several months prior to presentation but felt it had enlarged significantly in the past month. He denied any pain, pruritus, or bleeding. His medical history was significant for melanoma of the nose treated 47 years ago, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, and chronic back pain. The patient reported having the melanoma treated but was unaware of any other details concerning the lesion. He denied any allergies and his...
Source: Skinmed - December 31, 2016 Category: Dermatology Authors: Glick JB, Alapati U, Khachemoune A Tags: Skinmed Source Type: research

An asymptomatic diffuse palatal mass
An 82 year-old African-American woman presented for evaluation of “itchiness and tingling” of the palate and a poorly fitting maxillary denture of two months history. Her medical history was significant for hypertension, hyperlipidemia, atrial fibrillation, gout, gastroesophageal reflux disease and a history of left breast ductal carcinoma in-situ (status-post excision and radiation therapy in 2008). Her medications included diltiazem, pravastatin, allopurinol, colchicine, and omeprazole and she had no known drug allergies.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - March 15, 2017 Category: ENT & OMF Authors: Ahmed S. Sultan, Sook-Bin Woo Source Type: research

A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients
Conclusion: Methylene blue performed as well as patent blue in identifying the SLN in breast cancer patients.Resumo Introdu ção: O azul de metileno é mais facilmente encontrado para comercialização e a um preço menor que o azul patente. Parece ainda haver menor risco de anafilaxia. Objetivo: Comparar a taxa de detecção do linfonodo sentinela com o azul patente e com o azul de metileno. Método: Foram incluídas , de forma randomizada e prospectiva, 142 pacientes com diagnóstico de carcinoma mamário invasor, que consentiram em participar livremente do estudo. Foram injetados 2 mL de azul patente (grupo A) em 69 (4...
Source: Revista da Associacao Medica Brasileira - March 24, 2017 Category: Journals (General) Source Type: research

Association of atopy and tentative diagnosis of skin cancer ‐ results from occupational skin cancer screenings
ConclusionDesign limitations of the study include that all findings of skin cancer were based on clinical examination only and must therefore be considered tentative diagnoses. Furthermore, owing to the cross‐sectional study design, causal pathways cannot be proven. However, analyses of data from such a large and general population‐based cohort afford valuable insights into the relationship of atopic diseases and skin cancer. They provide the grounds for prospective cohort studies to evaluate and dissect the underlying mechanism.This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - July 6, 2017 Category: Dermatology Authors: I. Sch äfer, P. Mohr, N. Zander, R. Fölster‐Holst, M. Augustin Tags: Original Article Source Type: research