Acute Liver Failure of Non–A-E Etiology—Profile, Prognosis, and Predictors of Outcome
Publication date: Available online 16 January 2020Source: Journal of Clinical and Experimental HepatologyAuthor(s): Shalimar, Subrat K. Acharya, Ramesh Kumar, Gangadhar Bharath, Gyanranjan Rout, Deepak Gunjan, Baibaswata NayakBackground/objectivesAcute liver failure (ALF) is rare and associated with poor outcomes. The outcomes of ALF and predictors of outcome may vary as per the etiology. There are limited data on the predictors of spontaneous survival among patients with ALF of non–A-E hepatitis or cryptogenic etiology. We aimed to assess clinical course, complications, and outcome of non–A-E etiology ALF.Meth...
Source: Journal of Clinical and Experimental Hepatology - February 9, 2020 Category: Gastroenterology Source Type: research

Organ Procurement in the Brain Dead Donors Without In Vivo Cold Perfusion: A Novel Technique
ConclusionOur technique has not affected recipient outcomes and with benefits of less use of preservation solution, shortening bench surgery time, and decreasing the propensity of procurement injuries by avoiding cold-phase dissection. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - February 8, 2020 Category: Gastroenterology Source Type: research

Vascular Endothelial Growth Factor Promotes Proliferation of Epithelial Cell Adhesion Molecule–Positive Cells in Nonalcoholic Steatohepatitis
Publication date: Available online 10 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Hamda Siddiqui, Preety Rawal, Chaggan Bihari, Naveen Arora, Savneet KaurAimAn impaired hepatocyte proliferation during severe liver injury causes the proliferation of hepatic progenitor cells (HPCs), also called as the ductular reaction (DR). In the present study, we studied the role of key angiogenic factors in HPC-mediated DR in nonalcoholic steatohepatitis (NASH).MethodsLiver biopsies from patients with NASH (n = 14) were included in the study. Patients with NASH were divided in two groups, early and...
Source: Journal of Clinical and Experimental Hepatology - January 30, 2020 Category: Gastroenterology Source Type: research

Removal Notice to “Slimming to the Death: Herbalife® Associated Fatal Acute Liver Failure – Heavy Metals, Toxic Compounds, Bacterial Contaminants and Psychotropic Agents in Products Sold in India”, [J Clin Exp Hepatol 9 (2019) 268–272]
Publication date: January–February 2020Source: Journal of Clinical and Experimental Hepatology, Volume 10, Issue 1Author(s): Cyriac A. Philips, Philip Augustine, Sasidharan Rajesh, Solomon K. John, Gopakumar C. Valiathan, Jos Mathew, Sameer Phalkey, Kuruveetil L. Antony (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 30, 2020 Category: Gastroenterology Source Type: research

Issue Highlights
Publication date: January–February 2020Source: Journal of Clinical and Experimental Hepatology, Volume 10, Issue 1Author(s): (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 30, 2020 Category: Gastroenterology Source Type: research

Living Donor Liver Transplantation in a Paediatric Patient With Citrullinaemia Type 2
In conclusion, transplantation should be considered to be the definitive treatment for citrullinaemia type 2 at this stage, although some issues remain unresolved. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 30, 2020 Category: Gastroenterology Source Type: research

Combined Balloon-, Plug- and Coil-assisted Retrograde Transvenous Obliteration of Multiple Portosystemic Shunts to Treat Recurrent Hepatic Encephalopathy: A Case Report
We describe a patient who underwent balloon- and plug-assisted obliteration for a lienorenal and lienogonadal shunt, respectively. He returned with symptoms of recurrent hepatic encephalopathy two years later due to reformation of new lienorenal and lienogonadal shunts. Repeat obliteration of these new shunts was now performed using balloon and coil assistance. We describe the treatment for multiple portosystemic shunts with combined usage of vascular plug, balloon and coils depending on anatomical and technically factors. Our case also highlights that after shunt obliteration increased portal pressure may form new portosy...
Source: Journal of Clinical and Experimental Hepatology - January 18, 2020 Category: Gastroenterology Source Type: research

Acute Liver Failure of Non-A-E Etiology- Profile, Prognosis and Predictors of Outcome
Publication date: Available online 16 January 2020Source: Journal of Clinical and Experimental HepatologyAuthor(s): Shalimar, Subrat Kumar Acharya, Ramesh Kumar, B.G. Bharath, Gyanranjan Rout, Deepak Gunjan, Baibaswata NayakAbstractBackground/ObjectivesAcute liver failure is rare and associated with poor outcomes. The outcomes of ALF and predictors of outcome may vary as per the etiology. There is limited data on the predictors of spontaneous survival among patients with ALF of non-A-E hepatitis or cryptogenic etiology. We aimed to assess clinical course, complications, and outcome of non-A-E etiology ALF.MethodsIn this pr...
Source: Journal of Clinical and Experimental Hepatology - January 18, 2020 Category: Gastroenterology Source Type: research

The Current Hepatic Encephalopathy Pipeline
Publication date: Available online 14 January 2020Source: Journal of Clinical and Experimental HepatologyAuthor(s): Alexander J. Ryu, Robert S. Rahimi, Michael D. LeiseAbstractHepatic encephalopathy (HE) is a complication of acute or chronic liver failure; its mechanism is complex, involving multiple organ systems, and is still being elucidated. The standard of care, lactulose, has remained generally unchanged for decades. However, in recent years, better understanding of the pathophysiology has yielded new therapeutic targets for this reversible condition. These novel treatments act both on traditional pathways establishe...
Source: Journal of Clinical and Experimental Hepatology - January 15, 2020 Category: Gastroenterology Source Type: research

Organ procurement in the brain dead donors without in vivo cold perfusion-a novel technique
ConclusionOur technique has not affected recipient outcomes and with benefits of less use of preservation solution, shortening bench surgery time and decreasing the propensity of procurement injuries by avoiding cold phase dissection. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 9, 2020 Category: Gastroenterology Source Type: research

Liver Transplant in Acute Liver Failure – Looking Back Over 10 Years
ConclusionLT for ALF carries high perioperative mortality (35.7%) in those presenting with indeterminate etiology, pre-op renal dysfunction, and Grade IV HE. Nevertheless, if they survive the perioperative period, long-term survival is excellent. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 7, 2020 Category: Gastroenterology Source Type: research

Living donor Liver Transplantation in an Paediatric with Citrullinaemia Type 2
In conclusion,transplantation should be considered to be the definitive treatment for citrullinemia Type 2 at this stage, although some issues remain unresolved. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 7, 2020 Category: Gastroenterology Source Type: research

Incidence and Risk Factors for Hepatitis C Virus and Hepatitis B Virus Seroconversion in End-Stage Renal Failure Patients on Maintenance Hemodialysis
ConclusionIn a real-life scenario, HCV seroconversion is observed in 15% of the patients initiated on hemodialysis. Isolation of both dialysis machine and personnel was associated with lower seroconversion. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 1, 2020 Category: Gastroenterology Source Type: research

Sarcopenia in Cirrhosis: Fallout on Liver Transplantation
Publication date: Available online 31 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Vaibhaw Kumar, Jaya Benjamin, Varsha Shasthry, Kishore Gurumoorthy Subramanya Bharathy, Piyush Kumar Sinha, Guresh Kumar, Viniyendra PamechaAbstractBackgroundLiver transplantation (LT) is a game changer in cirrhosis. Poor muscle mass defined as sarcopenia may potentially upset the LT scoreboard.AimTo assess the prevalence and impact of sarcopenia on the intraoperative and early post-operative outcomes in Indian patients undergoing LT.MethodsPre LT, single slice routine CT images at L3 vertebra of 115 LT reci...
Source: Journal of Clinical and Experimental Hepatology - January 1, 2020 Category: Gastroenterology Source Type: research

Successful Treatment of Disseminated Hepatocellular Carcinoma After Liver Transplantation With Nivolumab
Publication date: Available online 5 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Waseem Amjad, Sandy Kotiah, Ankur Gupta, Michael Morris, Li Liu, Paul J. ThuluvathThe use of immunotherapy in transplant recipients is considered a contraindication because of very high risks for graft loss. The graft loss is to be expected because cytotoxic T-lymphocyte–associated protein-4 and programmed death 1 pathways are implicated in graft tolerance. In this case report, we describe a woman with recurrent, disseminated hepatocellular carcinoma who was successfully treated with nivolumab, an ...
Source: Journal of Clinical and Experimental Hepatology - December 29, 2019 Category: Gastroenterology Source Type: research

Corrigendum to “Wilson's Disease: Clinical Practice Guidelines of the Indian National Association for the Study of Liver (INASL), The Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) and the Movement Disorders Society of India (MDSI)” [J Clin Expt Hepatol 9 (2019) 74–98]
Publication date: Available online 10 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Aabha Nagral, Moinak S. Sarma, John Matthai, Prashanth L. Kukkle, Harshad Devarbhavi, Sanjib Sinha, Seema Alam, Ashish Bavdekar, Radha K. Dhiman, Chundamannil E. Eapen, Vinay Goyal, Neelam Mohan, Rukmini M. Kandadai, Malathi Sathiyasekaran, Ujjal Poddar, Anupam Sibal, Srinivas Sankaranarayanan, Anshu Srivastava, Baburam R. Thapa, Pettarusp M. Wadia (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - December 28, 2019 Category: Gastroenterology Source Type: research

Do recipients of genetically related donors have better outcomes after living donor liver transplantation?
ConclusionAlthough chronic rejection was found to be more common in genetically unrelated donors, the patient survival after LDLT was similar. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - December 28, 2019 Category: Gastroenterology Source Type: research

“Combined balloon, plug and coil assisted retrograde transvenous obliteration of multiple porto-systemic shunts to treat recurrent hepatic encephalopathy: A Case Report”
We describe a patient who underwent balloon and plug-assisted obliteration for a lienorenal and lienogonadal shunt respectively. He returned with symptoms of recurrent hepatic encephalopathy two years later due to re-formation of new lienorenal and lienogonadal shunts. Repeat obliteration of these new shunts was now performed using balloon and coilassistance. We describe the treatment for multiple porto-systemic shunts with combined usage of vascular-plug, balloon and coils depending on anatomical and technically factors. Our case also highlights that after shunt obliteration increased portal pressure may form new portosys...
Source: Journal of Clinical and Experimental Hepatology - December 28, 2019 Category: Gastroenterology Source Type: research

Predictors, Presentation, and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience
Publication date: Available online 22 November 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Sirina Ekpanyapong, Neil Philips, Bao-Li Loza, Peter Abt, Emma E. Furth, Rashmi Tondon, Vandana Khungar, Kim Olthoff, Abraham Shaked, Maarouf A. Hoteit, K. Rajender ReddyBackgroundLiver transplantation (LT) is an accepted therapeutic option for hepatocellular carcinoma (HCC) in patients with cirrhosis. Despite careful candidate selection, HCC recurrence occurs. We aimed to describe the predictors of recurrence, clinical presentation, and predictors of survival after HCC recurrence post-LT.MethodsPatients wit...
Source: Journal of Clinical and Experimental Hepatology - December 24, 2019 Category: Gastroenterology Source Type: research

Non–Wilson's Disease-Associated Hypoceruloplasminemia
ConclusionLow serum ceruloplasmin levels were documented in 4.0% of adult patients without WD attending this urban liver diseases outpatient clinic. These patients tend to be younger, less often men, and more often have viral hepatitis as the underlying cause of their liver disease. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - December 21, 2019 Category: Gastroenterology Source Type: research

Issue Highlights
Publication date: November–December 2019Source: Journal of Clinical and Experimental Hepatology, Volume 9, Issue 6Author(s): (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - December 13, 2019 Category: Gastroenterology Source Type: research

Pregnancy After Liver Transplantation: Outcomes From a Single-Center Experience
ConclusionsPregnancy after liver transplantation has a favorable outcome with a multidisciplinary team approach. There is a physiological reduction of tacrolimus trough levels during pregnancy for which dose augmentation is not usually required. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - December 12, 2019 Category: Gastroenterology Source Type: research

Vascular endothelial growth factor promotes proliferation of EpCAM-positive cells in non-alcoholic
Publication date: Available online 10 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Hamda Siddiqui, Preety Rawal, Chaggan Bihari, Naveen Arora, Savneet KaurAbstractAimAn impaired hepatocyte proliferation during severe liver injury causes the proliferation of hepatic progenitor cells (HPC), also called as the ductular reaction (DR). In the given study, we studied the role of key angiogenic factors in HPC-mediated DR in non-alcoholic steatohepatitis (NASH).MethodsLiver biopsies from patients with NASH (n=14) were included in the study. NASH patients were divided in two groups, early and late ...
Source: Journal of Clinical and Experimental Hepatology - December 11, 2019 Category: Gastroenterology Source Type: research

Corrigendum to “Wilson’s disease: Clinical practice guidelines of the Indian National Association for the study of Liver (INASL), The Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) and the Movement Disorders Society of India (MDSI)” [J Clin Expt Hepatol 9 (2019) 74–98]
Publication date: Available online 10 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Aabha Nagral, Moinak S. Sarma, John Matthai, Prashanth L. Kukkle, Harshad Devarbhavi, Sanjib Sinha, Seema Alam, Ashish Bavdekar, Radha K. Dhiman, Chundamannil E. Eapen, Vinay Goyal, Neelam Mohan, Rukmini M. Kandadai, Malathi Sathiyasekaran, Ujjal Poddar, Anupam Sibal, Srinivas Sankaranarayanan, Anshu Srivastava, Baburam R. Thapa, Pettarusp M. Wadia (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - December 10, 2019 Category: Gastroenterology Source Type: research

Successful treatment of post liver transplant disseminated HCC with nivolumab
Publication date: Available online 5 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Waseem Amjad, Sandy Kotiah, Ankur Gupta, Michael Morris, Li Liu, Paul J. ThuluvathAbstractThe use of immunotherapy in transplant recipients is considered a contraindication because of very high risks for graft loss. The graft loss is to be expected since cytotoxic T-lymphocyte associated protein-4 (CTLA-4) and PD-1 pathways are implicated in graft tolerance. In this case report, we describe a woman with recurrent, disseminated hepatocellular carcinoma who was successfully treated with nivolumab, an immune che...
Source: Journal of Clinical and Experimental Hepatology - December 6, 2019 Category: Gastroenterology Source Type: research

Use of terlipressin in cirrhosis with ascites: A questionnaire survey in China
Publication date: Available online 5 December 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Zhaohui Bai, Hongyu Li, Xiaozhong Guo, Xingshun Qi (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - December 6, 2019 Category: Gastroenterology Source Type: research

Sofosbuvir–Velpatasvir Fixed Drug Combination for the Treatment of Chronic Hepatitis C Infection in Patients With End-Stage Renal Disease and Kidney Transplantation
ConclusionOur study showed excellent efficacy with the safety profile of this drug combination in end-stage renal disease patients. However, larger prospective studies and multicenter randomized controlled trials are needed for further confirmation. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - December 3, 2019 Category: Gastroenterology Source Type: research

Cost-Effectiveness Analysis and Decision Modelling: A Tutorial for Clinicians
Publication date: Available online 26 November 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Nidhi Gupta, Rohan Verma, Radha Krishan Dhiman, Kavitha Rajsekhar, Shankar PrinjaAbstractCost effectiveness analysis provides information on how much extra do we need to spend per unit gain in health outcomes with introduction of any new healthcare intervention or treatment as compared to the alternative. This information is crucial to make decision regarding funding any new drug, diagnostic test or determining standard treatment protocol. It becomes even more important to consider this evidence in resource ...
Source: Journal of Clinical and Experimental Hepatology - November 27, 2019 Category: Gastroenterology Source Type: research

Prevalence of hepatitis B and hepatitis C among school children of urban and rural Jaipur, Rajasthan
Publication date: Available online 26 November 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Kapil Dhingra, Sandeep Ratra, Amit Tanwar, Munesh Kumar, Mukesh Jain, Gaurav Gupta, Shivi Nijhawan, Hemendra Bharadwaj, Manisha Nijhawn, Sandeep Nijhawan (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 27, 2019 Category: Gastroenterology Source Type: research

Incidence and risk factors for HCV and HBV seroconversion in end stage renal failure patients on maintenance haemodialysis
ConclusionIn a real-life scenario, HCV seroconversion is observed in 15% of the patients initiated on hemodialysis. Isolation of both dialysis machine and personnel was associated with lower seroconversion. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 27, 2019 Category: Gastroenterology Source Type: research

Non-Wilson’s Disease Associated Hypoceruloplasminemia
ConclusionLow serum ceruloplasmin levels were documented in 4.0% of adult non-WD patients attending this urban liver diseases outpatient clinic. These patients tend to be younger, less often male and more often have viral hepatitis as the underlying cause of their liver disease. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 26, 2019 Category: Gastroenterology Source Type: research

Celiac disease and portal hypertension: A causal association or just a Coincidence?
ConclusionCD is common in PHT of different etiology especially in cCLD, NCPH and Autoimmune hepatitis (AIH), however etiological basis for this association is still to be defined. The likelihood of CD is higher in liver disease as compared to general population and these patients should be screened for CD. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 23, 2019 Category: Gastroenterology Source Type: research

Diabetes and hepatocellular carcinoma: Incidence trends and impact of liver disease etiology
ConclusionsThe additive risk of T2DM for HCC development was highest in patients with NASH. HCC risk may vary depending on the underlying etiology. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 22, 2019 Category: Gastroenterology Source Type: research

Predictors, Presentation and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience
Publication date: Available online 22 November 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Sirina Ekpanyapong, Neil Philips., Bao-Li Loza, Peter Abt, Emma E. Furth, Rashmi Tondon, Vandana Khungar, Kim Olthoff, Abraham Shaked, Maarouf A. Hoteit, K. Rajender ReddyAbstractBackgroundLiver transplantation (LT) is an accepted therapeutic option for hepatocellular carcinoma (HCC) in patients with cirrhosis. Despite careful candidate selection, HCC recurrence occurs. We aimed to describe the predictors of recurrence, clinical presentation, and predictors of survival after HCC recurrence post-LT.MethodsPat...
Source: Journal of Clinical and Experimental Hepatology - November 22, 2019 Category: Gastroenterology Source Type: research

The predicament of the PREDICT study!!
Publication date: Available online 22 November 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Chandan Kumar Kedarisetty, Vanarasi Y. Bhargav, Mu. Karthikeyan, B.W.C. Sathiyasekaran, Jayanthi Venkataraman (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 22, 2019 Category: Gastroenterology Source Type: research

Sofosbuvir –Velpatasvir fixed drug combination for the treatment of chronic hepatitis C infection in patients with end-stage renal disease and kidney transplantation
ConclusionOur study showed excellent efficacy with the safety profile of this drug combination in End Stage Renal Disease patients. However, larger prospective studies and multicenter randomized controlled trials are needed for further confirmation. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 7, 2019 Category: Gastroenterology Source Type: research

2019 Update of Indian National Association for Study of the Liver Consensus on Prevention, Diagnosis, and Management of Hepatocellular Carcinoma in India: The Puri II Recommendations
We present here the 2019 Update of INASL Consensus on Prevention, Diagnosis, and Management of Hepatocellular Carcinoma in India: The Puri-2 Recommendations. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 1, 2019 Category: Gastroenterology Source Type: research

A 5-year Single-Center Experience of Hepatitis E Virus Infection During Pregnancy
ConclusionHEV infection has a higher incidence, more severe course, and greater mortality in the pregnant cohort than in the nonpregnant cohort. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 1, 2019 Category: Gastroenterology Source Type: research

Pregnancy after Liver Transplantation: Outcomes from a Single Center Experience
ConclusionsPregnancy following liver transplantation has a favorable outcome with a multidisciplinary team approach. There is a physiological reduction of tacrolimus trough levels during pregnancy for which dose augmentation is not usually required. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 1, 2019 Category: Gastroenterology Source Type: research

Comparative study of ultrasound-guided percutaneous omental biopsy in cirrhotics and noncirrhotics
ConclusionUS-guided omental biopsy in patients with liver cirrhosis is safe and effective with comparable results to noncirrhotic patients. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 1, 2019 Category: Gastroenterology Source Type: research

Liver Transplant In Acute Liver Failure – Looking Back Over 10 Years
ConclusionLT for ALF carries high perioperative mortality (35.7%) in those presenting with indeterminate etiology, pre-op renal dysfunction and Grade IV HE. Nevertheless, if they survive the perioperative period, long term survival is excellent. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 1, 2019 Category: Gastroenterology Source Type: research

Natural History of Simple Steatosis or Nonalcoholic Fatty Liver
Publication date: Available online 20 September 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Arka De, Ajay DusejaAbstractThe histological spectrum of nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis or nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis and hepatocellular carcinoma. Ballooning degeneration of hepatocytes with or without fibrosis is the key feature that differentiates NASH from NAFL. Liver biopsy is the only reliable method for diagnosing NAFL and differentiating it from NASH. Although the epidemiology of NAFLD is well ...
Source: Journal of Clinical and Experimental Hepatology - October 24, 2019 Category: Gastroenterology Source Type: research

Role Of Granulocyte Colony Stimulating Factor On The Short Term Outcome Of Children With Acute On Chronic Liver Failure
ConclusionThe present study shows that GCSF therapy at 5mcg/kg/day for 5 days seems to be ineffective in improving the survival outcome at Day 30 and 60 of therapy. Larger studies with a longer duration of therapy are required.Trial registration: Clinical Trials Registry India - CTRI/2017/11/010420;Trial Registration#: CTRI/2017/11/010420; www.ctri.nic.in. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 24, 2019 Category: Gastroenterology Source Type: research

NonInvasive Biomarkers in Nonalcoholic Fatty Liver Disease: Are We There Yet?
Publication date: Available online 21 September 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Shivaram P. Singh, Rakesh K. BarikNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. NAFLD encompasses a spectrum of disease ranging from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. However, despite the growing recognition of this important disease burden, there are significant challenges to accurately and noninvasively diagnose the various forms of NAFLD, especially to differentiate benign steatosis from t...
Source: Journal of Clinical and Experimental Hepatology - October 20, 2019 Category: Gastroenterology Source Type: research

Sustained Improvements in Markers of Liver Disease Severity After Hepatitis C Treatment
ConclusionHCV treatment in a large community-based cohort demonstrated sustained improvements in AST, ALT, PLT, and FIB-4. Rebound increases in AST, ALT, and FIB-4 observed in Hispanics and those with BMI>30 kg/m2 may reflect persisting nonalcoholic fatty liver disease. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 20, 2019 Category: Gastroenterology Source Type: research

Role of Magnetic Resonance Imaging in the Monitoring of Patients with Nonalcoholic Fatty Liver Disease: Comparison with Ultrasonography, Lipid Profile, and Body Mass Index
Publication date: Available online 20 September 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Nikhil Makhija, Naval K. Vikram, Gurdeep Kaur, Raju Sharma, Deep N. Srivastava, Kumble S. MadhusudhanAimThe aim of this study was to study the role of magnetic resonance imaging (MRI) in monitoring hepatic fat content in cases of nonalcoholic fatty liver disease (NAFLD).Materials and methods41 adults (mean age: 39 years, 22 males; 19 females) with NAFLD were included after obtaining approval from the institutional ethics committee. The baseline clinical (weight, body mass index [BMI]) and biochemical parame...
Source: Journal of Clinical and Experimental Hepatology - October 17, 2019 Category: Gastroenterology Source Type: research

Issue Highlights
Publication date: September–October 2019Source: Journal of Clinical and Experimental Hepatology, Volume 9, Issue 5Author(s): (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 5, 2019 Category: Gastroenterology Source Type: research

A 5 year single centre experience of Hepatitis E virus infection during pregnancy
ConclusionHepatitis E virus infection has a higher incidence, more severe course and greater mortality during pregnancy when compared to the non-pregnant cohort. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 5, 2019 Category: Gastroenterology Source Type: research

2019 Update of Indian National Association for Study of the Liver (INASL) Consensus on Prevention, Diagnosis and Management of Hepatocellular Carcinoma in India: The Puri II Recommendations
We present here the 2019 Update of INASL Consensus on Prevention, Diagnosis and Management of Hepatocellular Carcinoma in India: The Puri-2 Recommendations. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - September 23, 2019 Category: Gastroenterology Source Type: research

Non-invasive biomarkers in Non-alcoholic Fatty Liver Disease – are we there yet?
Publication date: Available online 21 September 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Shivaram Prasad Singh, Rakesh Kumar BarikAbstractNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. NAFLD encompasses a spectrum of disease ranging from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. However, despite the growing recognition of this important disease burden, there are significant challenges to accurately and non-invasively diagnose the various forms of NAFLD, especially to differentiate benig...
Source: Journal of Clinical and Experimental Hepatology - September 22, 2019 Category: Gastroenterology Source Type: research