Determinants of medication adherence in liver transplant recipients
ConclusionThe prevalence of non-adherence was 16.5%. Determinants of non-adherence were Deceased Donor Liver Transplant, belief in alternative medications, high regimen complexity, poor knowledge about medications and cost issues with long term medications. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - March 20, 2019 Category: Gastroenterology Source Type: research

Whole-Exome Sequencing Identifies a Variant in Phosphatidylethanolamine N-Methyltransferase Gene to be Associated With Lean-Nonalcoholic Fatty Liver Disease
ConclusionOur results demonstrate the association of rs7946 with lean-NAFLD. WES may be an effective strategy to identify causative variants underlying lean-NAFLD. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - March 16, 2019 Category: Gastroenterology Source Type: research

Wilson Disease Presenting With Acute on Chronic Liver Failure: A Single-Center Experience of Outcome and Predictors of Mortality in 68 Patients
ConclusionsWD with ACLF is associated with a high mortality Precipitating factors such as viral and drug-induced hepatitis was seen in 11.7% patients. Liver histology in patients subjected to biopsy showed cirrhosis in all. Only encephalopathy is a prognostic marker of non-survival with an accuracy of 82%. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - March 14, 2019 Category: Gastroenterology Source Type: research

Drug Development for NAFLD: Landscape and Challenges
Publication date: Available online 13 March 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Prarthana Thiagarajan, Guruprasad Padur AithalAbstractNon-alcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease in industrialised economies. With no licensed treatment currently available, together with a growing prevalence that parallels global increases in obesity and type 2 diabetes, NAFLD will dominate the landscape of hepatology for the foreseeable future. A multifaceted aetiopathogenesis, paucity of reproducible pre-clinical models that effectively recreate human NAFLD an...
Source: Journal of Clinical and Experimental Hepatology - March 14, 2019 Category: Gastroenterology Source Type: research

Impact of Vitamin D Status In Chronic Liver Disease
Publication date: Available online 13 March 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Mushtaq Ahmad Khan, Hilal Ahmad Dar, Muneer Ahmad Baba, Altaf Hussain Shah, Bhagat Singh, Nadeem Ahmad ShiekhAbstractBackgroundVitamin D deficiency is extremely common in chronic liver disease patients. Up to 93% of these patients have some degree of vitamin D insufficiency. Liver plays an important role in the metabolism and pleiotropic functions of vitamin D. Vitamin D deficiency has been associated with increased mortality, bacterial infections, portal hypertension complications and fibrosis severity. We aim...
Source: Journal of Clinical and Experimental Hepatology - March 13, 2019 Category: Gastroenterology Source Type: research

A Novel Phosphoinositide-3-kinase Adapter Protein 1 Gene Missense Mutation in Familial Cirrhosis
In this report, we shed light on a novel missense mutation associated with cirrhosis in a family of brothers associated with phosphoinositide-3-kinase adapter protein 1 gene through high-output whole exosome gene sequencing methodology. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - March 8, 2019 Category: Gastroenterology Source Type: research

Screening of Cardiovascular Disease in Nonalcoholic Fatty Liver Disease: Whom and How?
Publication date: Available online 15 February 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Narendra S. Choudhary, Ajay DusejaNonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. Patients with NAFLD are at a higher risk of developing cardiovascular disease (CVD). In fact, CVD-related mortality is more common in patients with NAFLD in comparison to liver-related mortality. This association is related to the common metabolic risk factors such as obesity, dyslipidemia, diabetes, and hypertension shared by both NAFLD and CVD, and also there is independent association of ...
Source: Journal of Clinical and Experimental Hepatology - March 8, 2019 Category: Gastroenterology Source Type: research

INASL – FOGSI Position Statement on Management of Liver Diseases in Pregnancy
Publication date: Available online 6 March 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Anil Arora, Ashish Kumar, Anil Chandra Anand, Pankaj Puri, Radha Krishan Dhiman, Subrat Kumar Acharya, Kiran Aggarwal, Neelam Aggarwal, Rakesh Aggarwal, Yogesh Kumar Chawla, Vinod Kumar Dixit, Ajay Duseja, Chundamannil E. Eapen, Bhabadev-Goswami, Kanwal-Gujral, Anoop Gupta, Ankur Jindal, Premashish Kar, Krishna Kumari, Kaushal MadanAbstractLiver diseases occurring during pregnancy can be serious and can progress rapidly affecting outcomes for both the mother and fetus. They are a common cause for concern to Obst...
Source: Journal of Clinical and Experimental Hepatology - March 6, 2019 Category: Gastroenterology Source Type: research

Magnitude of Nonalcoholic Fatty Liver Disease: Eastern Perspective
Publication date: Available online 7 February 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Becky Ching-Yeung Yu, Deborah Kwok, Vincent Wai-Sun WongNonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide, affecting a quarter of the global adult population. Nonalcoholic steatohepatitis, the more active form of NAFLD with active hepatic necroinflammation and faster fibrosis progression, has become one of the leading indications for liver transplantation and an important cause of hepatocellular carcinoma in Western countries. Epidemiological studies suggest...
Source: Journal of Clinical and Experimental Hepatology - March 1, 2019 Category: Gastroenterology Source Type: research

Fusion Image–Guided and Ultrasound-Guided Fine Needle Aspiration in Patients With Suspected Hepatic Metastases
Publication date: Available online 25 January 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Lawrence AJ, Naveen Kalra, Anmol Bhatia, Radhika Srinivasan, Ajay Gulati, Rakesh Kapoor, Vikas Gupta, Radha K. Dhiman, Yogesh Chawla, Niranjan KhandelwalAimThe aim of this study was to compare the diagnostic adequacy of computed tomography (CT)–ultrasound (US) fusion image–guided fine needle aspiration (FNA) and US-guided FNA in patients with suspected hepatic metastases.MethodsThirty consecutive patients of either sex with known or unknown primary malignancy suspected of having liver metastases o...
Source: Journal of Clinical and Experimental Hepatology - February 23, 2019 Category: Gastroenterology Source Type: research

Hepatocellular Carcinoma: Etiology and Current and Future Drugs
Publication date: Available online 25 January 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Aastha Jindal, Anusha Thadi, Kunwar ShailubhaiHepatocellular carcinoma (HCC) is swiftly increasing in prevalence globally with a high mortality rate. The progression of HCC in patients is induced with advanced fibrosis, mainly cirrhosis, and hepatitis. The absence of proper preventive or curative treatment methods encouraged extensive research against HCC to develop new therapeutic strategies. The Food and Drug Administration–approved Nexavar (sorafenib) is used in the treatment of patients with unresec...
Source: Journal of Clinical and Experimental Hepatology - February 20, 2019 Category: Gastroenterology Source Type: research

Wilson Disease Presenting with Acute on Chronic Liver Failure: A Single Center Experience of Outcome and Predictors of Mortality in Sixty-Eight Patients
ConclusionsWD with ACLF is associated with a high mortality Precipitating factors such as viral and drug-induced hepatitis was seen in 11.7% patients. Liver histology in patients subjected to biopsy showed cirrhosis in all. Only encephalopathy is a prognostic marker of non-survival with an accuracy of 82%. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - February 19, 2019 Category: Gastroenterology Source Type: research

Brain edema in chronic hepatic encephalopathy
Publication date: Available online 19 February 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Cristina Cudalbu, Simon D. Taylor-RobinsonAbstractBrain edema is a common feature associated with hepatic encephalopathy (HE). In patients with acute HE, brain edema has been shown to play a crucial role in the associated neurological deterioration. In chronic HE, advanced magnetic resonance imaging techniques (MRI) have demonstrated that low grade brain edema appears also to be an important pathological feature. This review explores the different methods used to measure brain edema ex vivo and in vivo in an...
Source: Journal of Clinical and Experimental Hepatology - February 19, 2019 Category: Gastroenterology Source Type: research

Screening of cardiovascular disease in non-alcoholic fatty liver disease: whom and how?
Publication date: Available online 15 February 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Narendra Singh Choudhary, Ajay DusejaAbstractNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. Patients with NAFLD are at a higher risk of developing cardiovascular disease (CVD). In fact, CVD related mortality is more common in patients with NAFLD in comparison to liver related mortality. This association is related to the common metabolic risk factors like obesity, dyslipidemia, diabetes and hypertension shared by both NAFLD and CVD, also there is independent association...
Source: Journal of Clinical and Experimental Hepatology - February 15, 2019 Category: Gastroenterology Source Type: research

Outcomes in clinical trials evaluating interventions for the prevention and treatment of hepatic encephalopathy
Publication date: Available online 15 February 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Lise L. Gluud, Rebecca Jeyaraj, Marsha Y. MorganAbstractRandomised clinical trials and systematic reviews of research findings can provide high-quality evidence for decision-making in the management of patients with hepatic encephalopathy. A large number of clinical trials have been undertaken, over the last 50 years, for the prevention and treatment of this condition. However, changes have been made, during this time, in the classification of hepatic encephalopathy, diagnostic criteria, and assessment measu...
Source: Journal of Clinical and Experimental Hepatology - February 15, 2019 Category: Gastroenterology Source Type: research

A Novel Phosphoinositide-3-Kinase (PI3K) Adaptor Protein 1 Gene Missense Mutation in Familial Cirrhosis
In this report, we shed light on a novel missense mutation associated with cirrhosis in a family of brothers associated with Phosphoinositide-3-Kinase (PI3K) Adaptor Protein 1 gene through high output whole exosome gene sequencing methodology. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - February 14, 2019 Category: Gastroenterology Source Type: research

Whole exome sequencing identifies a variant in Phosphatidylethanolamine N-methyltransferase (PEMT) gene to be associated with Lean-Nonalcoholic fatty Liver disease (NAFLD)
ConclusionOur results demonstrate the association of rs7946 with lean-NAFLD. Whole-exome sequencing may be an effective strategy to identify causative variants underlying lean-NAFLD. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - February 12, 2019 Category: Gastroenterology Source Type: research

Magnitude of non-alcoholic fatty liver disease: Eastern perspective
Publication date: Available online 7 February 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Becky Yu, Deborah Kwok, Vincent Wai-Sun WongAbstractNon-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide, affecting a quarter of the global adult population. Non-alcoholic steatohepatitis (NASH), the more active form of NAFLD with active hepatic necroinflammation and faster fibrosis progression, has become one of the leading indications for liver transplantation and an important cause of hepatocellular carcinoma in Western countries. Epidemiological studies su...
Source: Journal of Clinical and Experimental Hepatology - February 8, 2019 Category: Gastroenterology Source Type: research

The Ninth Year of JCEH: The Year of Expansion and Growth
Publication date: January–February 2019Source: Journal of Clinical and Experimental Hepatology, Volume 9, Issue 1Author(s): Radha K. Dhiman (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 26, 2019 Category: Gastroenterology Source Type: research

Special Section: Update in Hepatic Encephalopathy- Part III
Publication date: January–February 2019Source: Journal of Clinical and Experimental Hepatology, Volume 9, Issue 1Author(s): Madhumita Premkumar, Radha K. Dhiman (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 26, 2019 Category: Gastroenterology Source Type: research

Minimal/Covert Hepatic Encephalopathy – Impact of Comorbid Conditions
Publication date: January–February 2019Source: Journal of Clinical and Experimental Hepatology, Volume 9, Issue 1Author(s): Karin WeissenbornMild cognitive dysfunction as in minimal or covert hepatic encephalopathy (HE) can be found in a variety of metabolic disturbances, several neurological diseases, and even older age. Because liver cirrhosis usually is accompanied by one or the other of these, a differentiation between HE and cognitive decline because of comorbidities is difficult. Somehow discriminating is the impairment of motor speed and accuracy, which is more prominent in HE than in any of the comorbidities....
Source: Journal of Clinical and Experimental Hepatology - January 26, 2019 Category: Gastroenterology Source Type: research

Is It Safe to Perform Endoscopic Retrograde Cholangiopancreatography in Decompensated Cirrhosis?
ConclusionThough endoscopic sphincterotomy might be safe in the patients with cirrhosis undergoing ERCP; advanced liver cirrhosis may be independent risk factor for post ERCP adverse events. Cholangitis at admission is an independent risk factor for mortality. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 25, 2019 Category: Gastroenterology Source Type: research

Fusion Image-guided and Ultrasound-guided Fine Needle Aspiration in Patients with Suspected Hepatic Metastases
Publication date: Available online 25 January 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Lawrence AJ, Naveen Kalra, Anmol Bhatia, Radhika Srinivasan, Ajay Gulati, Rakesh Kapoor, Vikas Gupta, Radha K. Dhiman, Yogesh Chawla, Niranjan KhandelwalAbstractObjectiveTo compare the diagnostic adequacy of CT-ultrasound fusion image-guided fine needle aspiration (FNA) and ultrasound-guided FNA in patients with suspected hepatic metastases.Methods30 consecutive patients of either sex with known or unknown primary malignancy suspected of having liver metastases on both US and CT whose multiphasic CECT was don...
Source: Journal of Clinical and Experimental Hepatology - January 25, 2019 Category: Gastroenterology Source Type: research

Hepatocellular carcinoma: etiology, current and future drugs
Publication date: Available online 25 January 2019Source: Journal of Clinical and Experimental HepatologyAuthor(s): Aastha Jindal, Anusha Thadi, Kunwar ShailubhaiAbstractHepatocellular carcinoma (HCC) is swiftly increasing in prevalence globally with a high mortality rate. The progression of HCC in patients is induced with advanced fibrosis, mainly cirrhosis and hepatitis. The absence of proper preventive or curative treatment methods encouraged extensive research against HCC to develop new therapeutic strategies. The FDA approved Nexavar (Sorafenib) is used in the treatment of patients with unresectable HCC. In 2017, Stiv...
Source: Journal of Clinical and Experimental Hepatology - January 25, 2019 Category: Gastroenterology Source Type: research

Hepatic Encephalopathy is a Strong Predictor of Early Hospital Readmission Among Cirrhosis Patients
ConclusionsAmong underserved safety-net cirrhosis patients, 30-day hospital readmission rates were over 30%. Given that presence of hepatic encephalopathy was most strongly correlated with readmissions, targeted interventions to improve management of hepatic encephalopathy may have the greatest impact on improving cirrhosis-related outcomes. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 24, 2019 Category: Gastroenterology Source Type: research

Strategy and Efficacy of Generic and Pan-genotypic Sofosbuvir/Velpatasvir in Chronic Hepatitis C Virus: A Myanmar Experience
ConclusionsIn Myanmar, generic and pan-genotypic SOF/VEL ± RBV is a highly effective and safe treatment for HCV, regardless of the HCV genotype, and therefore, the requirement for the baseline genotype can be eliminated. Future strategies should include elimination of treatment and end of treatment HCV RNA testing to enhance treatment uptake and further reduce cost. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - January 17, 2019 Category: Gastroenterology Source Type: research

Strategy and Efficacy of Generic and Pangenotypic SOFOSBUVIR/VELPATASVIR in Chronic HCV: A Myanmar Experience
ConclusionsIn Myanmar, generic and pangenotypic SOF/VEL +/- RBV is a highly effective and safe treatment for HCV regardless of HCV genotype and therefore the requirement for baseline genotype can be eliminated. Future strategies should include elimination of on treatment and end of treatment HCV RNA testing to enhance treatment uptake and further reduce cost. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - December 19, 2018 Category: Gastroenterology Source Type: research

Patients With Budd–Chiari Syndrome Have Variable Coagulation Status on Thromboelastography at Diagnosis
Publication date: Available online 25 October 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Abhinav Jain, Prashant Dhore, Megha Meshram, Shobna Bhatia, Akash ShuklaBackground & aimsBudd–Chiari Syndrome (BCS) is considered a thrombophilic state, and most patients with BCS have thrombophilic disorder. Liver dysfunction–related coagulopathy makes coagulation function unpredictable in BCS. Thromboelastography (TEG) assesses the dynamics, strength, and stability of clot formation. We conducted a pilot study using TEG to evaluate coagulation status in patients with BCS.MethodsFifty-one pat...
Source: Journal of Clinical and Experimental Hepatology - December 9, 2018 Category: Gastroenterology Source Type: research

The Impact of Ethnic Subgroups on Tumor Stage at Diagnosis, Treatment Received, and Long-Term Survival Among Asian Adults With Hepatocellular Carcinoma
Publication date: Available online 12 November 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Justin R. Yu, Jennifer Wang, Taft Bhuket, Benny Liu, Robert J. WongBackground & aimsHepatocellular carcinoma (HCC) outcomes among Asians may differ by the Asian ethnic subgroup. We aim to evaluate the impact of the Asian ethnic subgroup on HCC tumor stage, treatment received, and overall survival among US adults.MethodsUsing the 2004–2012 Surveillance, Epidemiology, and End Results U.S. cancer registry, we retrospectively evaluated disparities in HCC tumor stage at diagnosis, HCC treatment rec...
Source: Journal of Clinical and Experimental Hepatology - December 7, 2018 Category: Gastroenterology Source Type: research

Molecular and Pathological Events Involved in the Pathogenesis of Diabetes-Associated Nonalcoholic Fatty Liver Disease
Publication date: Available online 12 November 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Onkar Bedi, Savera Aggarwal, Nirupma Trehanpati, Gayatri Ramakrishna, Pawan KrishanDiabetes mellitus is a rising epidemic in most part of the world and is often associated with multiple organ disorders such as kidney, liver, and cardiovascular diseases. Liver is a major metabolic hub, and the metabolic disorders associated with diabetes result in liver dysfunctions culminating in spectrum of liver diseases such as fatty liver disorders, cirrhosis, and hepatocellular carcinoma. The intervention strategies to ...
Source: Journal of Clinical and Experimental Hepatology - December 5, 2018 Category: Gastroenterology Source Type: research

Regression of Fibrosis After Direct-acting Antivirals Treatment of Patients with Hepatitis C Virus Cirrhosis: Transposability to Nondecompensated Patients
Publication date: Available online 8 November 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Edoardo G. Giannini, Mattia Crespi, Mariagiulia Demarzo, Giorgia Bodini, Manuele Furnari, Elisa Marabotto, Francesco Torre (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 30, 2018 Category: Gastroenterology Source Type: research

Update in hepatic encephalopathy - part ii
Publication date: December 2018Source: Journal of Clinical and Experimental Hepatology, Volume 8, Issue 4Author(s): Madhumita Premkumar, Radha K. Dhiman (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 30, 2018 Category: Gastroenterology Source Type: research

MHE Testing in Real World Scenario
Publication date: December 2018Source: Journal of Clinical and Experimental Hepatology, Volume 8, Issue 4Author(s): Mette M. Lauridsen, Hendrik VilstrupProfessional MHE awareness is high but when it comes to psychometric testing for MHE the real world scenario is characterized by hesitation and testing is offered only to selected cirrhosis patients. The hesitation is rooted in doubts about which tests to use, lack of knowledge about treatment benefits, and uncertainty about the tests’ ability to identify patients who will benefit from anti-HE treatment. Thus, the majority of MHE patients do not receive the available ...
Source: Journal of Clinical and Experimental Hepatology - November 30, 2018 Category: Gastroenterology Source Type: research

Delirium Tremens: Assessment and Management
Publication date: December 2018Source: Journal of Clinical and Experimental Hepatology, Volume 8, Issue 4Author(s): Sandeep Grover, Abhishek GhoshDelirium Tremens (DT) falls in the most severe spectrum of alcohol withdrawal, which could potentially result in death, unless managed promptly and adequately. The prevalence of DT in general population is
Source: Journal of Clinical and Experimental Hepatology - November 30, 2018 Category: Gastroenterology Source Type: research

Cost-effectiveness of Sorafenib for Treatment of Advanced Hepatocellular Carcinoma in India
ConclusionsSorafenib is not cost-effective for use in advanced hepatocellular carcinoma treatment in India. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 25, 2018 Category: Gastroenterology Source Type: research

A Case of Sirolimus-Induced Interstitial Lung Disease After Liver Transplantation
We present a case of sirolimus-induced ILD that improved after discontinuation of sirolimus. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 23, 2018 Category: Gastroenterology Source Type: research

Angioembolization of Post-traumatic Intrahepatic Arterioportal Fistula Presenting With Portal Hypertension
Publication date: Available online 26 October 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Amar Mukund, Rakhi Maiwall, Naveen Kumar CondatiTraumatic hepatic arterioportal fistula is an abnormal communication between the hepatic artery and portal vein and is a rare cause of non-cirrhotic portal hypertension with delayed presentation, usually after a remote history of abdominal trauma or an interventional procedure. This case report is of one such rare presentation, wherein a 59-year-old gentleman presented with unexplained ascites and complications of portal hypertension, eventually diagnosed with a...
Source: Journal of Clinical and Experimental Hepatology - November 23, 2018 Category: Gastroenterology Source Type: research

Molecular and pathological events involved in the pathogenesis of diabetes associated non-alcoholic fatty liver disease
Publication date: Available online 12 November 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Onkar Bedi, Savera Aggarwal, Nirupma Trehanpati, Gayatri Ramakrishna, Pawan KrishanAbstractDiabetes mellitus is a rising epidemic in most part of the world and is often associated with multiple organ disorders such as kidney, liver and cardiovascular diseases. Liver is a major metabolic hub and the metabolic disorders associated with diabetes result in liver dysfunctions culminating in spectrum of liver diseases such as fatty liver disorders, cirrhosis and hepatocellular carcinoma. The intervention strategie...
Source: Journal of Clinical and Experimental Hepatology - November 14, 2018 Category: Gastroenterology Source Type: research

The Impact of Ethnic Subgroup on Tumor Stage at Diagnosis, Treatment Received, and Long-Term Survival Among Asian Adults with Hepatocellular Carcinoma
Publication date: Available online 12 November 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Justin R. Yu, Jennifer Wang, Taft Bhuket, Benny Liu, Robert J. WongAbstractBackground & AimsHepatocellular carcinoma (HCC) outcomes among Asians may differ by Asian ethnic subgroup. We aim to evaluate the impact of Asian ethnic subgroup on HCC tumor stage, treatment received, and overall survival among U.S. adults.MethodsUsing the 2004-2012 Surveillance, Epidemiology, and End Results U.S. cancer registry we retrospectively evaluated disparities in HCC tumor stage at diagnosis, HCC treatment received, and...
Source: Journal of Clinical and Experimental Hepatology - November 14, 2018 Category: Gastroenterology Source Type: research

Accuracy of the simplified criteria for autoimmune hepatitis in children: Systematic review and decision analysis
ConclusionsSimplified criteria show high specificity and moderate sensitivity for the diagnosis of autoimmune hepatitis in children. A positive result can justify starting a therapeutic assay, but a negative result does not seem sufficient to rule out this condition. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 9, 2018 Category: Gastroenterology Source Type: research

Regression of Fibrosis After DAAs Treatment of Patients with HCV Cirrhosis: Transposability to Non-Decompensated Patients
Publication date: Available online 8 November 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Edoardo G. Giannini, Mattia Crespi, Mariagiulia Demarzo, Giorgia Bodini, Manuele Furnari, Elisa Marabotto, Francesco Torre (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 9, 2018 Category: Gastroenterology Source Type: research

Predictors of Successful Kasai Portoenterostomy and Survival with Native Liver at 2 Years in Infants with Biliary Atresia
ConclusionEarly age at KPE, use of postoperative steroid and prevention of cholangitis can result in successful KPE. Those with successful KPE are likely to survive with their native liver at 2 years. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 3, 2018 Category: Gastroenterology Source Type: research

The Macrophage Activation Marker Soluble CD163 is Associated With Early Allograft Dysfunction After Liver Transplantation
Publication date: Available online 5 October 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Karen L. Thomsen, Francis P. Robertson, Peter Holland-Fischer, Brian R. Davidson, Rajeshwar P. Mookerjee, Holger J. Møller, Rajiv Jalan, Henning GrønbækBackground/ObjectivesSoluble CD163 (sCD163), a macrophage activation marker, is upregulated in conditions of macrophage proliferation and activation. Elevated sCD163 levels have been associated with liver disease severity and progression. During liver transplantation, the implanted liver is exposed to ischaemia and reperfusion injury, result...
Source: Journal of Clinical and Experimental Hepatology - November 3, 2018 Category: Gastroenterology Source Type: research

Correlation of baseline Portal pressure (hepatic venous pressure gradient) and Indocyanine Green Clearance Test With Post-transarterial Chemoembolization Acute Hepatic Failure
ConclusionPretreatment evaluation of routine liver function is of fundamental importance before TACE. Baseline ICG retention test (ICG-R15) is a marker indicating the state of liver function in patients undergoing TACE and is an independent predictor for PTLF. Our study concludes that with a cutoff of 25, ICG-R15 has 92.9% accuracy, 90% sensitivity, and 87.5% specificity to predict hepatic failure after TACE. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - November 3, 2018 Category: Gastroenterology Source Type: research

Gastroesophageal Reflux—Is It Uncommon in Indian Patients With Decompensated Liver Cirrhosis?
Publication date: Available online 5 October 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Uday Sanglodkar, Mayank Jain, M.J. Alexander, Jayanthi VenkataramanAbstractThe prevalence of reflux symptoms among Indian patients with decompensated cirrhosis is not known. We prospectively collected data using a predesigned questionnaire. Out of 200 patients recruited in the study, only 9.5% had reflux symptoms. None of the risk factors like smoking, alcohol and tobacco use; sex; age and severity of ascites correlated with patient symptoms. The present study highlights that GERD symptoms are infrequent among...
Source: Journal of Clinical and Experimental Hepatology - November 2, 2018 Category: Gastroenterology Source Type: research

Cost Effectiveness of Sorafenib for Treatment of Advanced Hepatocellular Carcinoma in India
ConclusionsSorafenib is not cost-effective for use in advanced hepatocellular carcinoma treatment in India. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 31, 2018 Category: Gastroenterology Source Type: research

'Angioembolization of post-traumatic intrahepatic arterio-portal fistula presenting with portal hypertension'
Publication date: Available online 26 October 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Amar Mukund, Rakhi Maiwall, Naveen Kumar CondatiAbstractTraumatic hepatic arterio-portal fistula is an abnormal communication between the hepatic artery and portal vein and is a rare cause of non-cirrhotic portal hypertension with delayed presentation, usually following a remote history of abdominal trauma or an interventional procedure.This case report is of one such rare presentation, wherein a 59-year-old gentleman presented with unexplained ascites and complications of portal hypertension. Eventually diag...
Source: Journal of Clinical and Experimental Hepatology - October 27, 2018 Category: Gastroenterology Source Type: research

Patients with Budd Chiari Syndrome have variable coagulation status on Thromboelastography at diagnosis
Publication date: Available online 25 October 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Jain Abhinav, Prashant Dhore, Megha Meshram, Bhatia Shobna, Shukla AkashAbstractBackground & AimsBudd Chiari syndrome(BCS) is considered a thrombophilic state and most patients with BCS have thrombophilic disorder. Liver dysfunction related coagulopathy makes coagulation function unpredictable in BCS. Thromboelastography(TEG) assesses the dynamics, strength and stability of clot formation. We conducted a pilot study using TEG to evaluate coagulation status in patients with BCS.MethodsFifty-one patients wi...
Source: Journal of Clinical and Experimental Hepatology - October 26, 2018 Category: Gastroenterology Source Type: research

Prevalence of Minimal Hepatic Encephalopathy in Patients with Liver Cirrhosis: A Cross-Sectional, Clinico-Epidemiological, Multicenter, Nationwide Study in India: The PREDICT Study
ConclusionsThe disease burden of MHE is quite substantial in patients with cirrhosis with no apparent cognitive defect. Smoking, whether past or current, has significant association with the presence of MHE. Though MHE has been shown to adversely affect quality of life, prophylaxis for MHE is not routinely practiced in the Indian setting.The study has been registered under clinical trials registry of India (CTRI/2014/01/004306). (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 15, 2018 Category: Gastroenterology Source Type: research

Minimal/Covert Hepatic Encephalopathy Impact of Comorbid Conditions
Publication date: Available online 17 September 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Karin WeissenbornMild cognitive dysfunction as in minimal or covert hepatic encephalopathy (HE) can be found in a variety of metabolic disturbances, several neurological diseases, and even older age. Because liver cirrhosis usually is accompanied by one or the other of these, a differentiation between HE and cognitive decline because of comorbidities is difficult. Somehow discriminating is the impairment of motor speed and accuracy, which is more prominent in HE than in any of the comorbidities. The observa...
Source: Journal of Clinical and Experimental Hepatology - October 12, 2018 Category: Gastroenterology Source Type: research