Characterizations and application of CA/ZnO/AgNP composite nanofibers for sustained antibacterial properties

Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Abdul Wahab Jatoi, Ick Soo Kim, Hiroshi Ogasawara, Qing-Qing NiAbstractAlthough silver based nanofibers possess excellent bactericidal and bacteriostatic characteristics. However, excess release/contact with silver may induce harmful side-effects including carcinoma, argyria, argyrosis and allergies. Similarly, silver depletion may limit prolonged antibacterial activities as well. Thus present research proposes electrospun CA/ZnO/AgNPs composite nanofibers for biologically safer and sustained antibacterial applications. The ZnO/AgNPs were synthesized using dopamine hydrochloride (Dopa) as reducing agent to immobilize AgNPs on ZnO nanoparticles. A simple solution-mixing procedure effectively generated AgNPs on ZnO nanoparticles. Strong adhesive characteristics of Dopa initiate adsorption of silver ions on ZnO nanoparticle surfaces and its metal ion reducing properties generate AgNPs. Additionally, the Dopa mediation generates strongly adhered AgNPs. The ZnO/AgNPs were used to fabricate CA/ZnO/AgNPs nanofibers. Characterization techniques, XRD, XPS, TEM, FTIR and SEM confirmed synthesis of nanocomposites. Crystallite sizes of ZnO and AgNPs calculated by Debye-Scherrer equation were 17.85 nm and 11.68 nm respectively. Antibacterial assays confirmed CA/ZnO/AgNP's effectiveness in growth inhibition of E. coli and S. aureus strains on agar plate and in liquid medium. The nanofiber ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research

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Publication date: Available online 14 September 2019Source: Pharmacological ResearchAuthor(s): Rihui Wu, Xueting Mei, Yibiao Ye, Ting Xue, Jiasheng Wang, Wenjia Sun, Caixia Lin, Ruoxue Xue, Jiabao Zhang, Donghui XuAbstractZinc(II) complexes of curcumin display moderate cytotoxicity towards cancer cells at low micromolar concentrations. However, the clinical use of zinc(II) complexes is hampered by hydrolytic insolubility and poor bioavailability and their anticancer mechanisms remain unclear. Here, we investigated the efficacy and mechanism of action of a polyvinylpyrrolidone (PVP-k30)-based solid dispersion of Zn(II)-curc...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conclusions: The incidence of omental metastasis is not low in patients with USC. Visual assessment and omental biopsy may be insufficient for recognizing occult metastases. Omentectomy should be part of the staging surgery in USC patients because it provides additional information about survival. Prospective studies are needed to confirm these results. PMID: 31517308 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
Conclusions: Young women with stage I EC undergoing FSS showed a relatively satisfactory prognosis, equal to those receiving CRC. PMID: 31517302 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
Abstract A facile and rapid synthesis of multifunctional carbon nanodots (CNDs) was developed by using the acid-base neutralization spontaneous heat with glucose as precursor, 1,2-ethylenediamine (EDA) and concentrated nitric acid as dual N-dopants. The CND has a tremendous antioxidant potency, which represents effective inhibitory concentrations of reactive oxygen species that are significantly lower than ascorbic acid. Furthermore, minimum inhibitory concentration (MIC) assay revealed CNDs possessed significant antimicrobial activity for Gram-positive S. aureus and Gram-negative E. coli. Moreover, the CNDs are e...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract CA125/MUC16 is an ovarian tumor cell marker widely used as a biomarker in epithelial ovarian carcinoma. CA125/MUC16 is also used for evaluation of the ROMA (Risk of Ovarian Malignancy Algorithm) value. In this work, a Surface Plasmon Resonance Imaging (SPRI) biosensor for circulating CA125/MUC16 has been developed. The anti-MUC16 antibody was attached to a gold chip via a cysteamine linker. The EDS/NHS protocol was used for the covalent attachment of the antibody. The developed biosensor is specific for CA125/MUC16, and exhibits good recovery and acceptable precision. Its linear response range (2.2-150 U/...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract Cancer is one of the most widespread challenges and important diseases, which has the highest mortality rate. Lung cancer is the most common type of cancer, so that about 25% of all cancer deaths are related to the lung cancer. The lung cancer is classified as two different types with different treatment methodology: the small cell lung carcinoma and nonsmall cell lung carcinoma are two categories of the lung cancer. Since the lung cancer is often in the latent period in its early stages, therefore, early diagnosis of lung cancer has many challenges. Hence, there is a need for sensitive and reliable tools...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Abstract The possibility of achieving bacterial discrimination using a miniaturized aspiration ion mobility spectrometer model ChemPro-100i (Environics Oy) has been tested by interrogating the headspace air samples above in vitro bacterial cultures of three species - Escherichia coli, Bacillus subtilis and Staphylococcus aureus, respectively. The ChemPro-100i highly integrated seven sensor array, composed of one a-IMS cell, three MOS (metal oxide sensors), one FET (field effect transistor) sensor and two SC (semiconductor) sensors, provided enough analytical information to discriminate between the three bacterial ...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human diseases. FI...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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