Efficacy of pasireotide LAR for acromegaly: a prolonged real-world monocentric study
ConclusionPas-LAR is effective and safe and the early identification of responders is possible just after the first administration. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 1, 2024 Category: Endocrinology Source Type: research
Dual Role for L-[Methyl-11C]-Methionine PET in Acromegaly: Confirming Remission and Detecting Recurrence
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2024 Category: Nuclear Medicine Authors: Haberbosch, L., Gillett, D., MacFarlane, J., Koulouri, O., Mai, K., Spranger, J., Mannion, R., Cheow, H., Jones, J., Gurnell, M. Tags: Illustrated Post Source Type: research
Epidemiology and clinical picture of obstetric and gynecological conditions in women with acromegaly – a preliminary report
Introduction: Acromegaly is a rare disease caused by the excessive secretion of growth hormone most commonly by a pituitary neuroendocrine tumor. It is typically associated with changes in the external appearance of patients, but it can also lead to organ complications, occurring in the form of cardiovascular and metabolic disorders or carcinogenesis. The relationship between acromegaly and the gynecological diseases has not been investigated so far. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Konrad G órski, M. Zgliczyńska, I. Czajka-Oraniec, M. Stelmachowska-Banaś, W. Zgliczyński, M. Ciebiera Source Type: research
An international simulated-use study to assess nurses ’ preferences between two lanreotide syringes for patients with neuroendocrine tumours or acromegaly (PRESTO 3)
ConclusionNurses strongly preferred the user experience of the Somatuline Autogel syringe over the Lanreotide Pharmathen syringe. “Ease of use” and “comfortable to handle” were the most important syringe attributes, and performance rating was significantly higher with Somatuline Autogel versus Lanreotide Pharmathen syringe for all but one attribute.Graphical abstract (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 1, 2024 Category: Endocrinology Source Type: research
Profiling of unfolded protein response markers and effect of IRE1 α-specific inhibitor in pituitary neuroendocrine tumor
CONCLUSION: UPR markers in FPitNETs are implicated as dominant A-UPR but blunted T-UPR. KIRA8, enhanced with octreotide, unbalances UPR, leading to anti-tumor effects. Targeting IRE1α may provide a novel strategy to treat PitNETs.PMID:38289718 | DOI:10.1210/endocr/bqae008 (Source: Endocrinology)
Source: Endocrinology - January 30, 2024 Category: Endocrinology Authors: Shuhei Morita Shinsuke Uraki Hiroyuki Ariyasu Tomoya Tsuji Asako Doi Hiroto Furuta Toshikazu Yamoto Naoyuki Nakao Takashi Akamizu Taka-Aki Matsuoka Source Type: research
Editorial: Treatment outcomes, comorbidities and impact of discordant biochemical values in acromegaly
(Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 29, 2024 Category: Endocrinology Source Type: research
Recurrent acromegaly: a systematic review on therapeutic approaches
Management of recurrent acromegaly is challenging for both neurosurgeons and endocrinologists. Several treatment options including repeat surgery, medical therapy, and radiation are offered for such patients. ... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - January 26, 2024 Category: Endocrinology Authors: Seyed Farzad Maroufi, Mohammadmahdi Sabahi, Seyed Sahab Aarabi, Mohammad Samadian, Rocco Dabecco, Badih Adada, Karla M. Arce and Hamid Borghei-Razavi Tags: Research Source Type: research
GSE249129 Management of Pediatric Gigantism Caused by the TADopathy, X-Linked Acrogigantism
Contributors : Manuela C Caruso ; Diego Mazzatenta ; Sofia Asioli ; Giuseppe Costanza ; Giampaolo Trivellin ; Martin Franke ; Dayana Abboud ; Julien Hanson ; Veronique Raverot ; Patrick Petrossians ; Albert Beckers ; Marco Cappa ; Adrian F DalySeries Type : OtherOrganism : Homo sapiensX-linked acrogigantism (X-LAG) is a rare form of pituitary gigantism that is associated with growth hormone (GH) and prolactin-secreting pituitary adenomas/pituitary neuroendocrine tumors (PitNETs) that develop in infancy. It is caused by a duplication on chromosome Xq26.3 that leads to misexpression of the gene GPR101, a constitut...
Source: GEO: Gene Expression Omnibus - January 23, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Real-life data of Pasireotide LAR in acromegaly: a long-term follow-up
ConclusionIn real-life settings, PAS-LAR significantly decreases symptoms, IGF-1 levels, and the size of adenoma in patients with acromegaly resistant to SRLs. Beneficial effects may occur early after the first injection. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 20, 2024 Category: Endocrinology Source Type: research
Efficacy of cabergoline in non-irradiated patients with acromegaly: a multi-centre cohort study
CONCLUSIONS: In non-irradiated patients, cabergoline normalises IGF-1 in around one-third and achieves both IGF-1 and GH targets in approximately one out of ten cases. SRL+cabergoline is less efficient than previously reported possibly due to differences in studies methodology and impact of confounding factors.PMID:38231133 | DOI:10.1093/ejendo/lvae003 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 17, 2024 Category: Endocrinology Authors: Sandrine A Urwyler Irene Samperi Kirstie Lithgow Akash Mavilakandy Mike Matheou Karin Bradley Aparna Pal Narendra L Reddy John Ay Niki Karavitaki Source Type: research
Double pituitary neuroendocrine tumors in a patient with normal growth hormone level acromegaly: A case report and review of the literature
CONCLUSION: Diagnosing acromegaly with low GH levels requires close monitoring. Double PitNETs are relatively rare and can cause incomplete remission of functional PitNETs.PMID:38213454 | PMC:PMC10783686 | DOI:10.25259/SNI_718_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - January 12, 2024 Category: Neurosurgery Authors: Ichiro Nakazato Kenichi Oyama Hisashi Ishikawa Yusuke Tabei Chie Inomoto Yoshiyuki Osamura Akira Teramoto Akira Matsuno Source Type: research
Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy
ConclusionsMortality remains significantly high in patients with acromegaly, irrespectively of disease status, as long as the follow-up is sufficiently long with a low rate of patients lost to follow-up. Therapy strategy including radiotherapy does not have an impact on mortality. Oncological causes of death currently outweigh the cardiovascular causes. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - January 12, 2024 Category: Endocrinology Source Type: research
Oculo-facio-cardio-dental (OFCD) syndrome: a case report
ConclusionOculo-facio-cardio-dental syndrome (OFCD) is an extremely rare condition characterized by abnormalities in the eyes, face, heart, and teeth, often caused by variants in the BCOR gene. Radiculomegaly, or enlarged dental roots, is a key diagnostic feature of OFCD, and early detection is crucial for preventing future dental complications. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 4, 2024 Category: General Medicine Source Type: research
