Profiling of unfolded protein response markers and effect of IRE1 α-specific inhibitor in pituitary neuroendocrine tumor

CONCLUSION: UPR markers in FPitNETs are implicated as dominant A-UPR but blunted T-UPR. KIRA8, enhanced with octreotide, unbalances UPR, leading to anti-tumor effects. Targeting IRE1α may provide a novel strategy to treat PitNETs.PMID:38289718 | DOI:10.1210/endocr/bqae008

Source: Endocrinology - January 30, 2024 Category: Endocrinology Authors: Shuhei Morita Shinsuke Uraki Hiroyuki Ariyasu Tomoya Tsuji Asako Doi Hiroto Furuta Toshikazu Yamoto Naoyuki Nakao Takashi Akamizu Taka-Aki Matsuoka Source Type: research