The changing landscape of acromegaly - an epidemiological perspective
We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mo...
Source: ENDOCR REV - February 10, 2024 Category: Endocrinology Authors: Christian Rosendal Mai Christiansen Arlien-S øborg Eigil Husted Nielsen Marianne Skovsager Andersen Claus Larsen Feltoft Caroline Kistorp Olaf M Dekkers Jens Otto Lunde J ørgensen Jakob Dal Source Type: research
The changing landscape of acromegaly - an epidemiological perspective
We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mo...
Source: ENDOCR REV - February 10, 2024 Category: Endocrinology Authors: Christian Rosendal Mai Christiansen Arlien-S øborg Eigil Husted Nielsen Marianne Skovsager Andersen Claus Larsen Feltoft Caroline Kistorp Olaf M Dekkers Jens Otto Lunde J ørgensen Jakob Dal Source Type: research
The changing landscape of acromegaly - an epidemiological perspective
We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mo...
Source: ENDOCR REV - February 10, 2024 Category: Endocrinology Authors: Christian Rosendal Mai Christiansen Arlien-S øborg Eigil Husted Nielsen Marianne Skovsager Andersen Claus Larsen Feltoft Caroline Kistorp Olaf M Dekkers Jens Otto Lunde J ørgensen Jakob Dal Source Type: research
The changing landscape of acromegaly – an epidemiological perspective
We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mo...
Source: Reviews in Endocrine and Metabolic Disorders - February 10, 2024 Category: Endocrinology Source Type: research
Cancers, Vol. 16, Pages 726: Alternations of Blood Pressure Following Surgical or Drug Therapy for Prolactinomas
bing Shang
Zhe Bao Wu
Several subtypes of pituitary neuroendocrine tumors (PitNETs), such as acromegaly and Cushing’s disease, can result in hypertension. However, whether prolactinoma is associated with this complication remains unknown. Moreover, the effect of treatment with surgery or drugs on blood pressure (BP) is unknown. Herein, a retrospective study reviewed 162 patients with prolactinoma who underwent transsphenoidal surgery between January 2005 and December 2022. BP measurements were performed 1 day before and 5 days after surgery. Accordingly, patients’ medical characteristics w...
Source: Cancers - February 9, 2024 Category: Cancer & Oncology Authors: Yijun Cheng Dapeng Wang Hao Tang Debing Tong Weiguo Zhao Shaojian Lin Hong Yao Wenwen Lv Xun Zhang Li Xue Hanbing Shang Zhe Bao Wu Tags: Article Source Type: research
Management of pasireotide-induced hyperglycemia in patients with acromegaly: An experts ’ consensus statement
Pasireotide is a somatostatin analogue for the treatment of acromegaly, a chronic condition caused by excess growth hormone. Despite the therapeutic benefits of pasireotide as a second-line treatment for inadequately controlled acromegaly, a major concern is its hyperglycemic side-effect. Here, we provide guidance on how to select appropriate patients with acromegaly for treatment with pasireotide. We summarize baseline characteristics of patients at high risk for pasireotide-associated hyperglycemia and recommend a monitoring strategy based on the risk profile. Self-monitoring of blood glucose levels (SMBG), measurements ...
Source: Frontiers in Endocrinology - February 9, 2024 Category: Endocrinology Source Type: research
KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
DISCUSSION: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
DISCUSSION: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
CONCLUSIONS AND RELEVANCE: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
CONCLUSIONS AND RELEVANCE: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
KDM1A genotyping and expression in 146 sporadic somatotroph pituitary adenomas
CONCLUSIONS AND RELEVANCE: Unlike in GIP-dependent primary bilateral macronodular adrenal hyperplasia, KDM1A genetic variations are not the cause of GIPR expression in somatotroph pituitary adenomas. Recurrent KDM1A haploinsufficiency, more frequently observed in GIPR-expressing adenomas, could be responsible for decreased KDM1A function resulting in transcriptional derepression on the GIPR locus.PMID:38330165 | DOI:10.1093/ejendo/lvae013 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - February 8, 2024 Category: Endocrinology Authors: Fanny Chasseloup Daniela Regazzo Lucie Tosca Alexis Proust Emmanuelle Kuhn Mirella Hage Christel Jublanc Karima Mokhtari Mattia Dalle Nogare Serena Avallone Filippo Ceccato Gerard Tachdjian Sylvie Salenave Jacques Young Stephan Gaillard Fabrice Parker Ann Source Type: research
Role of IL33 in chronic inflammation and microvascular damage as a reflection of organ damage on a cohort of patients with acromegaly
ConclusionSerum IL33 is higher in AP compared to HC; conversely a reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction, strictly dependent on acromegaly and are not influenced by the choice of treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 8, 2024 Category: Endocrinology Source Type: research
Preferences for different treatment options among people living with acromegaly in the US
CONCLUSION: The results indicate that new treatment options administered as subcutaneous injections right under the skin once every fourth week at home have the potential to lower the treatment burden among people with acromegaly, emphasizing the importance of taking each person's preference into consideration when choosing treatment.PMID:38317571 | DOI:10.1080/03007995.2024.2314244 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - February 6, 2024 Category: Research Authors: Jill Sisco Mattias Furumalm Cecilie Yssing Anna Okkels Stojan Zavisic Source Type: research
