The changing landscape of acromegaly  - an epidemiological perspective

We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mortality of patients with acromegaly to a level similar to that of the general population. Moreover, the underlying cause of death has shifted from cardiovascular to malignant neoplastic diseases.PMID:38337125 | DOI:10.1007/s11154-024-09875-z

Source: ENDOCR REV - February 10, 2024 Category: Endocrinology Authors: Christian Rosendal Mai Christiansen Arlien-S øborg Eigil Husted Nielsen Marianne Skovsager Andersen Claus Larsen Feltoft Caroline Kistorp Olaf M Dekkers Jens Otto Lunde J ørgensen Jakob Dal Source Type: research