Cancers, Vol. 16, Pages 726: Alternations of Blood Pressure Following Surgical or Drug Therapy for Prolactinomas

Cancers, Vol. 16, Pages 726: Alternations of Blood Pressure Following Surgical or Drug Therapy for Prolactinomas Cancers doi: 10.3390/cancers16040726 Authors: Yijun Cheng Dapeng Wang Hao Tang Debing Tong Weiguo Zhao Shaojian Lin Hong Yao Wenwen Lv Xun Zhang Li Xue Hanbing Shang Zhe Bao Wu Several subtypes of pituitary neuroendocrine tumors (PitNETs), such as acromegaly and Cushing’s disease, can result in hypertension. However, whether prolactinoma is associated with this complication remains unknown. Moreover, the effect of treatment with surgery or drugs on blood pressure (BP) is unknown. Herein, a retrospective study reviewed 162 patients with prolactinoma who underwent transsphenoidal surgery between January 2005 and December 2022. BP measurements were performed 1 day before and 5 days after surgery. Accordingly, patients’ medical characteristics were recorded. In addition, in situ rat and xenograft nude-mice prolactinoma models have been used to mimic prolactinoma. In vivo BP and serum prolactin (PRL) levels were measured after cabergoline (CAB) administration in both rats and mice. Our data suggest that surgery can effectively decrease BP in prolactinoma patients with or without hypertension. The BP-lowering effect was significantly associated with several variables, including age, sex, disease duration, tumor size, invasion, dopamine agonists (DAs)-resistance, recurrence, and preoperative PRL levels. Moreover, i...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research