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Total 24197 results found since Jan 2013.
Association between weight loss agents and elevated liver enzymes: a population-based cross-sectional study
This study aimed to investigate the associations between weight loss agents and elevated liver enzymes at the population-level. We conducted a cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES) data from 2013 to 2019. This study included 36,259 participants over 20 years of age who completed the questionnaire and had no history of hepatitis, cancer, or renal failure. In these participants, we analyzed associations between weight loss agents and elevated liver enzymes by constructing multiple logistic regression models with adjustment for confounding factors and stratified by sex, a...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ye-Jee Kim Seo Young Kang Mi-Sook Kim Joongyub Lee Bo Ram Yang Source Type: research
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
In conclusion, Hyp can activate the TFEB-mediated autophagy-lysosomal pathway and mitochondrial biogenesis through inhibition of mTORC1 activity, alleviating the liver injury induced by PAs, thus suggesting the potential value of Hyp in the treatment of PA-induced hepatotoxicity.PMID:37733287 | DOI:10.1007/s12272-023-01460-3
Source: Archives of Pharmacal Research - September 21, 2023 Category: Drugs & Pharmacology Authors: Jie Xu Aizhen Xiong Xunjiang Wang Xing Yan Yilin Chen Xuanling Ye Zhengtao Wang Lili Ding Li Yang Source Type: research
Randomised controlled trial of Jiandu granule in preventing chemoradiotherapy-induced oral mucositis
CONCLUSION: Jiandu granule reduced the incidence of severe oral mucositis in nasopharyngeal carcinoma patients during concurrent chemoradiotherapy and had an acceptable safety profile.PMID:37731218 | DOI:10.1111/odi.14745
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Huakang Li Jianlong Ke Xiaoyan Wang Bo Xu Qiang Li Ziliang Wu Yue Wang Bing Lin Source Type: research
Ivy leaf dry extract EA 575 for the treatment of acute and chronic cough in pediatric patients: review and expert survey
CONCLUSIONS: EA 575 has minimal side effects in pediatric patients with cough, as demonstrated by large, real-world studies. EA 575 may provide clinical benefits in pediatric patients; however, more robust clinical trials are needed to confirm its efficacy.PMID:37731370 | DOI:10.1080/03007995.2023.2258777
Source: Current Medical Research and Opinion - September 21, 2023 Category: Research Authors: Georg Seifert Laura Upstone Christopher P Watling Christian Vogelberg Source Type: research
Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals
Biomed Pharmacother. 2023 Sep 19;167:115502. doi: 10.1016/j.biopha.2023.115502. Online ahead of print.ABSTRACTPatients with diabetes are at risk for liver disorders including glycogen hepatopathy, non-alcoholic fatty liver disease, cirrhosis, and hepatic fibrosis. The pathophysiological mechanisms behind diabetic hepatopathy are complex, some of them include fatty acid accumulation, increased reactive oxygen species, increased advanced glycation end-products, hyperactivity of polyol pathways, increased apoptosis and necrosis, and promotion of fibrosis. A growing number of studies have shown that herbal extracts and their a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Leila Mobasheri Mitra Ahadi Ali Beheshti Namdar Mohaddeseh Sadat Alavi Abolfazl Bemidinezhad Seyed Mostafa Moshirian Farahi Mahdi Esmaeilizadeh Niloofar Nikpasand Elham Einafshar Ahmad Ghorbani Source Type: research
Novel antidepressant mechanism of hypericin: Role of connexin 43-based gap junctions
Biomed Pharmacother. 2023 Sep 19;167:115545. doi: 10.1016/j.biopha.2023.115545. Online ahead of print.ABSTRACTHypericin is widely utilized for its precise antidepressant properties, but its exact antidepressant mechanism remains unclear. Gap junctions, which were predominantly expressed in astrocytes in the central nervous system, are concerned with the pathogenesis of depression. However, the role of hypericin in gap junctional dysfunction in depression has rarely been investigated. Here, we found that gap junctions were ultra-structurally broadened in the chronic unpredictable stress (CUS) rat model of depression, while ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Huiqin Wang Xueying Yang Huaqing Lai Yang Sun Xu Yan Qidi Ai Meiyu Lin Songwei Yang Yantao Yang Shifeng Chu Zhenzhen Wang Naihong Chen Source Type: research
Ivy leaf dry extract EA 575 for the treatment of acute and chronic cough in pediatric patients: review and expert survey
CONCLUSIONS: EA 575 has minimal side effects in pediatric patients with cough, as demonstrated by large, real-world studies. EA 575 may provide clinical benefits in pediatric patients; however, more robust clinical trials are needed to confirm its efficacy.PMID:37731370 | DOI:10.1080/03007995.2023.2258777
Source: Current Medical Research and Opinion - September 21, 2023 Category: Research Authors: Georg Seifert Laura Upstone Christopher P Watling Christian Vogelberg Source Type: research
The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo
Biomed Pharmacother. 2023 Sep 18;167:115511. doi: 10.1016/j.biopha.2023.115511. Online ahead of print.ABSTRACTCorydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components of many Chinese Traditional Medicine prescriptions such as Jin Ling Zi San and Yuanhu-Zhitong priscription. C. yanhusuo was traditionally used to relieve pain and motivate blood and Qi circulation. Now there has been growing interest in pharmacological effects of alkaloids, the main bioactive components of C. yanhusuo. Eighty-four alkaloids isolated from C. yanhusuo are its important bioactive components a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Jia-Hua Feng Kang Chen Si-Yu Shen Yun-Feng Luo Xi-Hong Liu Xin Chen Wei Gao Yu-Ru Tong Source Type: research
Characterization and comparison of cardiomyocyte protection activities of non-starch polysaccharides from six ginseng root herbal medicines
Int J Biol Macromol. 2023 Sep 18;253(Pt 3):126994. doi: 10.1016/j.ijbiomac.2023.126994. Online ahead of print.ABSTRACTGinseng is rich of polysaccharides, however, the evidence supporting polysaccharides to distinguish various ginseng species is rarely reported. Focusing on six root ginseng (e.g., Panax ginseng-PG, P. quinquefolius-PQ, P. notoginseng-PN, red ginseng-RG, P. japonicus-PJ, and P. japonicus var. major-PJM), the contained non-starch polysaccharides (NPs) were structurally characterized and compared by both the chemical and biological evaluation. Holistic fingerprinting at three levels (the NPs and the acid hydro...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Jie Liu Xue Li Jing-Wen Guo Bo-Xue Chen He Sun Jia-Qi Huang Ying Hu Xiao-Yan Xu Mei-Ting Jiang Xiu-Mei Gao Wen-Zhi Yang Qi-Long Wang De-An Guo Source Type: research
The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo
Biomed Pharmacother. 2023 Sep 18;167:115511. doi: 10.1016/j.biopha.2023.115511. Online ahead of print.ABSTRACTCorydalis yanhusuo W. T. Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one of the herb components of many Chinese Traditional Medicine prescriptions such as Jin Ling Zi San and Yuanhu-Zhitong priscription. C. yanhusuo was traditionally used to relieve pain and motivate blood and Qi circulation. Now there has been growing interest in pharmacological effects of alkaloids, the main bioactive components of C. yanhusuo. Eighty-four alkaloids isolated from C. yanhusuo are its important bioactive components a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Jia-Hua Feng Kang Chen Si-Yu Shen Yun-Feng Luo Xi-Hong Liu Xin Chen Wei Gao Yu-Ru Tong Source Type: research
Study on the Therapeutic Effect of Coconut Oil Extracts as An Alternative Medicinal Plant in < em > Cryptosporidium < /em > Infected Mice
CONCLUSION: The present study has opened fresh avenues for development of natural therapy like coconut oil extracts, which have a potential therapeutic efficacy against Cryptosporidiosis. That was confirmed by different methodologies, parasitological examination, histopathological examination, and immunohistochemical assays. It paves the way for being a promising anti-parasitic agent for infection eradication. However, further studies are still required to gain more knowledge about different coconut extracts in order to reach the best treatment efficacy.PMID:37724361 | DOI:10.4274/tpd.galenos.2023.22932
Source: Turkish Society for Parasitology - September 19, 2023 Category: Parasitology Authors: Heba M El Naggar Basant O Mohammed Tarek Aboushousha Hagar F Abdelmaksoud Source Type: research
Analysing potent biomarkers along phytochemicals for breast cancer therapy: an in silico approach
CONCLUSION: The target-ligand complex of green tea active compound Epigallocatechin gallate with NOTCH (1-4) had the potential to become potent anti-breast cancer therapeutic candidates following further research involving wet-lab experiments.PMID:37726449 | DOI:10.1007/s10549-023-07107-7
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Nivruthi Shekar Paton Vuong Parwinder Kaur Source Type: research
The role of NLRP3 inflammasome in sepsis: A potential therapeutic target
Int Immunopharmacol. 2023 Feb;115:109697. doi: 10.1016/j.intimp.2023.109697. Epub 2023 Jan 20.ABSTRACTSepsis is the host immune imbalance following infection and leads to organ dysfunction, with highly complicated pathophysiology. To date, sepsis still lacks effective therapies with high mortality rates. Recently, numerous studies have highlighted the potential of NLRP3 inflammasome as a therapeutic target during sepsis. NLRP3 inflammasome is a protein complex that could induce the activation of caspase-1 and the following release of pro-inflammatory cytokines such as IL-1β and IL-18. It was demonstrated that NLRP3 inflam...
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Wenfang He Haiyun Dong Chenfang Wu Yanjun Zhong Jinxiu Li Source Type: research
Anti-Cancer Effect of < em > Dorema Ammoniacum Gum < /em > by Targeting Metabolic Reprogramming by Regulating < em > APC, P53, KRAS < /em > Gene Expression in HT-29 Human Colon Cancer Cells
CONCLUSION: This study's results indicate that the dichloromethane solvent of Dorema ammoniacum gum exhibits its antitumor properties by altering the expression of genes involved in HT-29 cells and the consequent change in downstream metabolic reprogramming.PMID:37724146 | PMC:PMC10505474 | DOI:10.52547/rbmb.12.1.127
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Elham Ghodousi-Dehnavi Mohammad Arjmand Ziba Akbari Mansour Aminzadeh Reza Haji Hosseini Source Type: research
