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Role of Bioactive Compounds, Novel Drug Delivery Systems, and Polyherbal Formulations in the Management of Rheumatoid Arthritis
Comb Chem High Throughput Screen. 2023 Sep 14. doi: 10.2174/1386207326666230914103714. Online ahead of print.ABSTRACTRheumatoid Arthritis (RA) is an autoimmune disorder that generally causes joint synovial inflammation as well as gradual cartilage and degenerative changes, resulting in progressive immobility. Cartilage destruction induces synovial inflammation, including synovial cell hyperplasia, increased synovial fluid, and synovial pane development. This phenomenon causes articular cartilage damage and joint alkalosis. Traditional medicinal system exerts their effect through several cellular mechanisms, including inhib...
Source: Combinatorial Chemistry and High Throughput Screening - September 15, 2023 Category: Chemistry Authors: Neha Rana Piyush Gupta Hridayanand Singh K Nagarajan Source Type: research
Hedyotis Diffusa-Scutellaria Barbata inhibits Breast Cancer Ethyl Acetate Fraction from Hedyotis Diffusa Plus Scutellaria Barbata inhibits the Progression of Breast Cancer via Targeting LMO1 and AKT/Mtor Signaling Pathway
CONCLUSION: In conclusion, the SH herb pair inhibited the proliferation and metastasis through downregulating LMO1 expression and reducing the activation of the AKT/mTOR signaling pathway. LMO1 has the potential as a new target in the treatment of breast cancer.PMID:37711008 | DOI:10.2174/1386207326666230913105858
Source: Combinatorial Chemistry and High Throughput Screening - September 15, 2023 Category: Chemistry Authors: Zhiyuan Li Jingwei Li Xiaofei Liu Ziyuan Sun Xiaohui Sun Source Type: research
Amazonian medicinal plants efficiently inactivate Herpes and Chikungunya viruses
This study contributes to the understanding of medicinal species native to the Brazilian Amazon, revealing their potential in combating viral infections that have plagued humanity for centuries (HSV-1) or currently lack specific therapeutic interventions (CHIKV).PMID:37713986 | DOI:10.1016/j.biopha.2023.115476
Source: Herpes - September 15, 2023 Category: Infectious Diseases Authors: Catielen Paula Pavi Isabella Dai Pr á Rafael Dorighello Cadamuro Isamu Kanzaki Jhuly Wellen Ferreira Lacerda Louis Pergaud Sandjo Roberto Messias Bezerra Jorge Federico Orellana Segovia Gislaine Fongaro Izabella Tha ís Silva Source Type: research
Role of Bioactive Compounds, Novel Drug Delivery Systems, and Polyherbal Formulations in the Management of Rheumatoid Arthritis
Comb Chem High Throughput Screen. 2023 Sep 14. doi: 10.2174/1386207326666230914103714. Online ahead of print.ABSTRACTRheumatoid Arthritis (RA) is an autoimmune disorder that generally causes joint synovial inflammation as well as gradual cartilage and degenerative changes, resulting in progressive immobility. Cartilage destruction induces synovial inflammation, including synovial cell hyperplasia, increased synovial fluid, and synovial pane development. This phenomenon causes articular cartilage damage and joint alkalosis. Traditional medicinal system exerts their effect through several cellular mechanisms, including inhib...
Source: Combinatorial Chemistry and High Throughput Screening - September 15, 2023 Category: Chemistry Authors: Neha Rana Piyush Gupta Hridayanand Singh K Nagarajan Source Type: research
Hedyotis Diffusa-Scutellaria Barbata inhibits Breast Cancer Ethyl Acetate Fraction from Hedyotis Diffusa Plus Scutellaria Barbata inhibits the Progression of Breast Cancer via Targeting LMO1 and AKT/Mtor Signaling Pathway
CONCLUSION: In conclusion, the SH herb pair inhibited the proliferation and metastasis through downregulating LMO1 expression and reducing the activation of the AKT/mTOR signaling pathway. LMO1 has the potential as a new target in the treatment of breast cancer.PMID:37711008 | DOI:10.2174/1386207326666230913105858
Source: Combinatorial Chemistry and High Throughput Screening - September 15, 2023 Category: Chemistry Authors: Zhiyuan Li Jingwei Li Xiaofei Liu Ziyuan Sun Xiaohui Sun Source Type: research
Traditional uses, phytochemistry, pharmacology, and toxicology of the genus Artemisia L. (Asteraceae): A high-value medicinal plant
Curr Top Med Chem. 2023 Sep 14. doi: 10.2174/1568026623666230914104141. Online ahead of print.ABSTRACTBiologically active secondary metabolites, essential oils, and volatile compounds derived from medicinal and aromatic plants play a crucial role in promoting human health. Within the large family Asteraceae, the genus Artemisia consists of approximately 500 species. Artemisia species have a rich history in traditional medicine worldwide, offering remedies for a wide range of ailments, such as malaria, jaundice, toothache, gastrointestinal problems, wounds, inflammatory diseases, diarrhoea, menstrual pains, skin disorders, ...
Source: Current Topics in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Manzoor Hussain Rakesh Kr Thakur Jabeena Khazir Sajad Ahmed Mohammad Imtiyaj Khan Praveen Rahi Latif Ahmad Peer V S Pragadheesh Satwinderjeet Kaur S N Raina Zafar Ahmad Reshi Deepmala Sehgal Vijay Rani Rajpal Bilal Ahmad Mir Source Type: research
Corilagin alleviates LPS-induced sepsis through inhibiting pyroptosis via targeting TIR domain of MyD88 and binding CARD of ASC in macrophages
Biochem Pharmacol. 2023 Sep 13:115806. doi: 10.1016/j.bcp.2023.115806. Online ahead of print.ABSTRACTSepsis is a dysregulated systemic inflammatory response caused by infection that leads to multiple organ injury and high mortality without effective treatment. Corilagin, a natural polyphenol extracted from traditional Chinese herbs, exhibits strong anti-inflammatory properties. However, the role for Corilagin in lipopolysaccharide (LPS)-induced sepsis and the molecular mechanisms underlying this process have not been completely explored. Here we determine the effect of Corilagin on LPS-treated mice and use a screening appr...
Source: Biochemical Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Senquan Wu Jia Liao Guodong Hu Liang Yan Xingyu Su Jiezhou Ye Chanjuan Zhang Tian Tian Huadong Wang Yiyang Wang Source Type: research
Traditional uses, phytochemistry, pharmacology, and toxicology of the genus Artemisia L. (Asteraceae): A high-value medicinal plant
Curr Top Med Chem. 2023 Sep 14. doi: 10.2174/1568026623666230914104141. Online ahead of print.ABSTRACTBiologically active secondary metabolites, essential oils, and volatile compounds derived from medicinal and aromatic plants play a crucial role in promoting human health. Within the large family Asteraceae, the genus Artemisia consists of approximately 500 species. Artemisia species have a rich history in traditional medicine worldwide, offering remedies for a wide range of ailments, such as malaria, jaundice, toothache, gastrointestinal problems, wounds, inflammatory diseases, diarrhoea, menstrual pains, skin disorders, ...
Source: Current Topics in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Manzoor Hussain Rakesh Kr Thakur Jabeena Khazir Sajad Ahmed Mohammad Imtiyaj Khan Praveen Rahi Latif Ahmad Peer V S Pragadheesh Satwinderjeet Kaur S N Raina Zafar Ahmad Reshi Deepmala Sehgal Vijay Rani Rajpal Bilal Ahmad Mir Source Type: research
Network pharmacology and molecular docking to explore the mechanism of Sheng Xue Bao mixture against iron deficiency anemia
Medicine (Baltimore). 2023 Sep 15;102(37):e35012. doi: 10.1097/MD.0000000000035012.ABSTRACTBased on network pharmacology and molecular docking, we investigated the mechanism of action of Sheng Xue Bao mixture (SXBM) in treating iron deficiency anemia (IDA). We screened the HERB and traditional Chinese medicine systems pharmacology database and analysis platform databases to identify the active ingredients and targets of SXBM. The targets associated with "iron deficiency anemia" were collected from GeneCards, TTD, and OMIM databases. A component-target interaction network was constructed using Cytoscape 3.8.2. The protein-p...
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Yun Wang Huang Qinqin Haixia Wang Hongxu Zhang Xinhua Zhang Weiguo Liu Zhenhua Xiang Yuming Gu Source Type: research
Traditional uses, phytochemistry, pharmacology, and toxicology of the genus Artemisia L. (Asteraceae): A high-value medicinal plant
Curr Top Med Chem. 2023 Sep 14. doi: 10.2174/1568026623666230914104141. Online ahead of print.ABSTRACTBiologically active secondary metabolites, essential oils, and volatile compounds derived from medicinal and aromatic plants play a crucial role in promoting human health. Within the large family Asteraceae, the genus Artemisia consists of approximately 500 species. Artemisia species have a rich history in traditional medicine worldwide, offering remedies for a wide range of ailments, such as malaria, jaundice, toothache, gastrointestinal problems, wounds, inflammatory diseases, diarrhoea, menstrual pains, skin disorders, ...
Source: Current Topics in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Manzoor Hussain Rakesh Kr Thakur Jabeena Khazir Sajad Ahmed Mohammad Imtiyaj Khan Praveen Rahi Latif Ahmad Peer V S Pragadheesh Satwinderjeet Kaur S N Raina Zafar Ahmad Reshi Deepmala Sehgal Vijay Rani Rajpal Bilal Ahmad Mir Source Type: research
Mentha pulegium: A Plant With Several Medicinal Properties
Endocr Metab Immune Disord Drug Targets. 2023 Sep 14. doi: 10.2174/1871530323666230914103731. Online ahead of print.ABSTRACTThe species Mentha pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and a...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Smail Amtaghri Miloudia Slaoui Mohamed Eddouks Source Type: research
Amazonian medicinal plants efficiently inactivate Herpes and Chikungunya viruses
This study contributes to the understanding of medicinal species native to the Brazilian Amazon, revealing their potential in combating viral infections that have plagued humanity for centuries (HSV-1) or currently lack specific therapeutic interventions (CHIKV).PMID:37713986 | DOI:10.1016/j.biopha.2023.115476
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Catielen Paula Pavi Isabella Dai Pr á Rafael Dorighello Cadamuro Isamu Kanzaki Jhuly Wellen Ferreira Lacerda Louis Pergaud Sandjo Roberto Messias Bezerra Jorge Federico Orellana Segovia Gislaine Fongaro Izabella Tha ís Silva Source Type: research
Mentha pulegium: A Plant With Several Medicinal Properties
Endocr Metab Immune Disord Drug Targets. 2023 Sep 14. doi: 10.2174/1871530323666230914103731. Online ahead of print.ABSTRACTThe species Mentha pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and a...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Smail Amtaghri Miloudia Slaoui Mohamed Eddouks Source Type: research
Role of Bioactive Compounds, Novel Drug Delivery Systems, and Polyherbal Formulations in the Management of Rheumatoid Arthritis
Comb Chem High Throughput Screen. 2023 Sep 14. doi: 10.2174/1386207326666230914103714. Online ahead of print.ABSTRACTRheumatoid Arthritis (RA) is an autoimmune disorder that generally causes joint synovial inflammation as well as gradual cartilage and degenerative changes, resulting in progressive immobility. Cartilage destruction induces synovial inflammation, including synovial cell hyperplasia, increased synovial fluid, and synovial pane development. This phenomenon causes articular cartilage damage and joint alkalosis. Traditional medicinal system exerts their effect through several cellular mechanisms, including inhib...
Source: Combinatorial Chemistry and High Throughput Screening - September 15, 2023 Category: Chemistry Authors: Neha Rana Piyush Gupta Hridayanand Singh K Nagarajan Source Type: research
Hedyotis Diffusa-Scutellaria Barbata inhibits Breast Cancer Ethyl Acetate Fraction from Hedyotis Diffusa Plus Scutellaria Barbata inhibits the Progression of Breast Cancer via Targeting LMO1 and AKT/Mtor Signaling Pathway
CONCLUSION: In conclusion, the SH herb pair inhibited the proliferation and metastasis through downregulating LMO1 expression and reducing the activation of the AKT/mTOR signaling pathway. LMO1 has the potential as a new target in the treatment of breast cancer.PMID:37711008 | DOI:10.2174/1386207326666230913105858
Source: Combinatorial Chemistry and High Throughput Screening - September 15, 2023 Category: Chemistry Authors: Zhiyuan Li Jingwei Li Xiaofei Liu Ziyuan Sun Xiaohui Sun Source Type: research
