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Total 24197 results found since Jan 2013.

An insight of naturally occurring phytoconstituents and novel approaches towards the treatment of diabetes
CONCLUSION: Conventional or synthetic drugs provide relief for short time but nanoformulations of phytomolecules offer an improved therapeutic with fewer negative side effects. Herbal medicines are rich in phytoconstituents and possess variety of health benefits. This review is compilation of phytoconstituents and novel drug delivery system of phytomolecules i.e nanoparticles, niosomes, microsphere, microparticle and others.PMID:37644751 | DOI:10.2174/1573399820666230829094724
Source: Current Diabetes Reviews - August 30, 2023 Category: Endocrinology Authors: Zulfa Nooreen Awani Kumar Rai Fariha Summayya Sudeep Tandon Source Type: research

Types of Nursing Intervention on Improving Quality of Life among Patients with Diabetes Mellitus: A Systematic Review
CONCLUSION: Sequentially, the most common types of nursing interventions to improve the QoL of DM patients was health education, followed by exercise, WA/SMS gateway, and glucose control. A personal approach to health education is a significant point in improving the QoL of DM patients in the future. The findings of this study might not be strongly generalized, so further randomized controlled trial (RCT) studies with larger samples are needed.PMID:37644750 | DOI:10.2174/1573399820666230829103016
Source: Current Diabetes Reviews - August 30, 2023 Category: Endocrinology Authors: Agung Samsu Alam Amin Samiasih Fatkul Mubin Satriya Pranata Reina Dhamanik Source Type: research

Inter- and intraspecific diversity of Salix bark phenolic profiles - A resource for the pharmaceutical industry
Fitoterapia. 2023 Aug 28:105660. doi: 10.1016/j.fitote.2023.105660. Online ahead of print.ABSTRACTDue to their content of phenolic compounds, willow bark preparations are used as an herbal remedy. The large diversity of phenolic secondary metabolites in Salix still provides a resource for the identification of bioactive compounds in particular species, including species not yet in focus from a phytopharmaceutical perspective. The present study describes the bark phenolic profile of 13 Salix species analyzed by HPLC-MS: Salix alba, Salix babylonica, Salix daphnoides, Salix fragilis, Salix hastata, Salix myrsinifolia, Salix ...
Source: Fitoterapia - August 30, 2023 Category: Biochemistry Authors: Angela K öhler Nadja F örster Matthias Zander Christian Ulrichs Source Type: research

Hosimosines A-E, structurally diverse cytisine derivatives from the seeds of Ormosia hosiei Hemsl. et Wils
Fitoterapia. 2023 Aug 28:105661. doi: 10.1016/j.fitote.2023.105661. Online ahead of print.ABSTRACTOrmosia hosiei Hemsl. et Wils (Fabaceae family) is an arbor species endemic to China. The seeds of O. hosiei have been used as traditional Chinese medicine to treat hernia, abdominal pain, blood stasis and amenorrhea. Cytisine-like and angustifoline type alkaloids were main components identified from this plant. In our research on the bioactive alkaloids from the promising Chinese medicinal plants, four new angustifoline type alkaloids (1-4) and a new cytisine-like alkaloid (5), named hosimosine A-E, together with 13 known ana...
Source: Fitoterapia - August 30, 2023 Category: Biochemistry Authors: Qing-Qing Zhou Xiao-Yan Xie Jia-Wen Zhu Wei-Wei Pan Bao-Gang Xie Wu Zhou Jin-Biao Xu Source Type: research

Secondary metabolites from Aspergillus terreus F6-3, a marine fungus associated with Johnius belengerii
Fitoterapia. 2023 Aug 28;170:105662. doi: 10.1016/j.fitote.2023.105662. Online ahead of print.ABSTRACTTwo new terrein derivatives asperterreinones A-B (1-2), one new octahydrocoumarin derivative (±)-asperterreinin A (6), along with seventeen known compounds, were isolated from Aspergillus terreus F6-3, a marine fungus associated with Johnius belengerii. The structures of 1, 2, and 6 were established on the basis of 1D and 2D NMR, mass spectroscopy, comparative electronic circular dichroism (ECD) spectra analysis, density functional theory calculation of 13C NMR, and DP4+ probability analysis. Among all the isolates, euryl...
Source: Fitoterapia - August 30, 2023 Category: Biochemistry Authors: Youmin Ying Shubao Tu Jiayue Ni Xuejun Lu Xiaoyan Hu Panyi Lei Xingnuo Li Ying Wang Guoqian Jin Hong Wang Source Type: research

Antidiabetic and antioxidant properties of Paeonia mascula L.: In vitro and in vivo studies, and phytochemical analysis
This study aimed to investigate the in vitro α-glucosidase enzyme inhibition effect, in vivo antidiabetic, and antioxidant activities of extracts obtained from P. mascula. The in vivo studies were conducted on diabetic rats induced with streptozotocin. The ethyl acetate and n-butanol extracts showed the highest efficacy in both in vitro and in vivo experiments, reducing AST, ALT, and MDA levels while increasing GSH and SOD activities in rats. In total, seven compounds were isolated from both extracts, and their structures were identified using spectroscopic methods such as 1D and 2D NMR and Mass Spectrometry. The in vitro...
Source: Fitoterapia - August 30, 2023 Category: Biochemistry Authors: Sefa G özcü Rustem Anil Ugan Hilal Özbek Bet ül Gündoğdu Zuhal Guvenalp Source Type: research

Avicularin alleviates acute liver failure by regulation of the TLR4/MyD88/NF- κB and Nrf2/HO-1/GPX4 pathways to reduce inflammation and ferroptosis
J Cell Mol Med. 2023 Aug 29. doi: 10.1111/jcmm.17905. Online ahead of print.ABSTRACTAcute liver failure (ALF) is an inflammation-mediated hepatocyte death process associated with ferroptosis. Avicularin (AL), a Chinese herbal medicine, exerts anti-inflammatory and antioxidative effects. However, the protective effect of AL and the mechanism on ALF have not been reported. Our in vivo results suggest that AL significantly alleviated lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced hepatic pathological injury, liver enzymes, inflammatory cytokines, reactive oxygen species and iron levels and increased the antioxidant...
Source: J Cell Mol Med - August 30, 2023 Category: Molecular Biology Authors: Pei Shi Wentao Zhu Jiwei Fu An Liang Ting Zheng Zhilong Wen Xincheng Wu Yuchen Peng Songsong Yuan Xiaoping Wu Source Type: research

Pharmacological Benefits and Underlying Mechanisms of < em > Salvia miltiorrhiza < /em > against Molecular Pathology of Various Liver Diseases: A Review
Am J Chin Med. 2023 Aug 30:1-35. doi: 10.1142/S0192415X23500763. Online ahead of print.ABSTRACTSalvia miltiorrhiza Bunge, called Danshen in Chinese, is the dried root and rhizome of S. miltiorrhiza, which is part of the mint family, Lamiaceae; it has chiefly been used to treat blood stasis and improve blood flow in cerebrovascular and cardiovascular diseases for over 2000 years. Recent preclinical studies have indicated that S. miltiorrhiza has a wide range of pharmacological properties making it useful for the treatment of diverse liver diseases. S. miltiorrhiza protects the liver from harmful hepatotoxins, reduces hepati...
Source: The American Journal of Chinese Medicine - August 30, 2023 Category: Complementary Medicine Authors: Cho Hyun Hwang Eungyeong Jang Jang-Hoon Lee Source Type: research

Genus Gelsemium and its endophytic fungi - Comprehensive review of their traditional uses, phytochemistry, pharmacology, and toxicology
CONCLUSION: It is clearly suggested from the literature information that the structures and biological activities of Gelsemium have a wide range of attraction from folk to the community of scholars. However, as a highly toxic genus, the work on the detoxification mechanism and toxicology of Gelsemium is urgently needed before entering clinical research. It is noteworthy that the discussion about the relationship between structural and biological activities are a valuable topic of expectation, while the structural modification for active or toxic components may shed light on toxicological breakthrough. Besides the compounds...
Source: Current Topics in Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Yun-Lin Peng Jia-Jun Liang Yan Xue Afsar Khan Pan-Pan Zhang Ting-Ting Feng Da Song Ying Zhou Xin Wei Source Type: research

Integrated network pharmacology to investigate the mechanism of Salvia miltiorrhiza Bunge in the treatment of myocardial infarction
J Cell Mol Med. 2023 Aug 29. doi: 10.1111/jcmm.17932. Online ahead of print.ABSTRACTSalvia miltiorrhiza Bunge is a natural drug for treating myocardial infarction (MI). However, the targets and mechanisms of S. miltiorrhiza Bunge in the treatment of MI are yet to be elucidated. Traditional Chinese medicine systems pharmacology (TCMSP) data were used to screen out chemical constituents, and UniProt was used to predict relevant targets. Disease targets were obtained from the Online Mendelian Inheritance in Man and GeneCards databases. We used the STRING platform to build a protein-protein interaction network and used Cytosca...
Source: J Cell Mol Med - August 29, 2023 Category: Molecular Biology Authors: Xueying Huang Muxin Zhang Yu Song Bowen Sun Lin Lin Xiaoli Song Chao Li Source Type: research

Attempt to identify antimicrobial Tridax procumbens (TP) mechanical properties using experimental work coupled with FEM model for biomedical applications
In this study, fresh TP liquid extracts blended with carboxymethylcellulose (CMC) biofilm were developed through the solution casting method. The casted film was tested for tensile strength through the Universal Tensile Tester (UTT), and the results were compared with the Finite Element Numerical Model (FEM) through the FEM code developed on the ANSYS solver. The experimental mean tensile test results for pure CMC were found as follows: tensile stress at the maximum of 15.31 MPa, modulus of elasticity of 7,24 GPa, the density of 1,62 g/cm3, and Poisson's ratio of 0.22. The experimental mean tensile test results for pure CM...
Source: Journal of the Mechanical Behavior of Biomedical Materials - August 28, 2023 Category: Materials Science Authors: C Balaji Ayyanar Sofiene Helaili Sanjay Mavinkere Rangappa Pawinee Boonyasopon Suchart Siengchin Source Type: research

A comparative study on essential oils from the leaves and stems of Vietnamese < em > Mikania micrantha < /em > Kunth
In this study, the essential oils from leaves and stems of M. micrantha were extracted by hydrodistillation method, and the chemical profiles of essential oils were then analysed by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC/MS). It was found that there were similarities and differences in chemical compositions and their percentage between the essential oils obtained from these two parts. The dominant components of leaves essential oil are β-Cubebene, Germacrene D, and α-Zingiberene, accounting for 11.34%, 10.96%, and 10.76%, respectively. Additionally, the major components of stems...
Source: Natural Product Research - August 28, 2023 Category: Biochemistry Authors: Quoc Trung Nguyen Khanh Ly Huynh Thi Minh Phuc Nguyen Thien Trinh Ngoc Thach Pham Minh Nhut Ho Yen Nhi Tran Thi Ngoc Quyen Tran Phuong Le Thi Source Type: research

Mapping of traditional healthcare providers and their healing approaches in a tribal community of district Sirohi, Rajasthan
CONCLUSION: Ethnopharmacological data is the foundation for further validation and value addition of herbal healthcare practices. The mapping of indigenous knowledge holders and scientific documentation of their knowledge might be a crucial step for providing clue regarding new therapeutic molecules.PMID:37636156 | PMC:PMC10451593 | DOI:10.4103/jfmpc.jfmpc_1610_22
Source: Primary Care - August 28, 2023 Category: Primary Care Authors: Rakhi Dwivedi Prachi Goyal Suraj S Yadav Pradeep Dwivedi Pratibha Singh Kuldeep Singh Source Type: research