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Transcription factor-based biosensors for detection of naturally occurring phenolic acids
N Biotechnol. 2023 Sep 13:S1871-6784(23)00047-X. doi: 10.1016/j.nbt.2023.09.004. Online ahead of print.ABSTRACTPhenolic acids including hydroxybenzoic and hydroxycinnamic acids are secondary plant and fungal metabolites involved in many physiological processes offering health and dietary benefits. They are often utilised as precursors for production of value-added compounds. The limited availability of synthetic biology tools, such as whole-cell biosensors suitable for monitoring the dynamics of phenolic acids intracellularly and extracellularly, hinders the capabilities to develop high-throughput screens to study their me...
Source: New Biotechnology - September 15, 2023 Category: Biotechnology Authors: Ernesta Augustiniene Ingrida Kutraite Egle Valanciene Paulius Matulis Ilona Jonuskiene Naglis Malys Source Type: research
Different stimuli induce endothelial dysfunction and promote atherosclerosis through the Piezo1/YAP signaling axis
Arch Biochem Biophys. 2023 Sep 14;747:109755. doi: 10.1016/j.abb.2023.109755. Online ahead of print.ABSTRACTVascular endothelial dysfunction is the initial step in atherosclerosis (AS). AS tends to occur at vascular bifurcations and curves, and endothelial cells(ECs) are highly susceptible to injury due to mechanical forces induced by disturbed flow (DF) with inconsistent blood flow directions. However, the pathogenesis of endothelial cell dysfunction in AS remains unclear and needs further study. Here, we found that Piezo1 expression was significantly increased in DF- and oxidized low-density lipoprotein(ox-LDL)-treated H...
Source: Archives of Biochemistry and Biophysics - September 15, 2023 Category: Biochemistry Authors: Jingying Mao Ronghao Yang Ping Yuan Fei Wu Yan Wei Yongmei Nie Chunxiang Zhang Xiangyu Zhou Source Type: research
Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
World Psychiatry. 2023 Oct;22(3):366-387. doi: 10.1002/wps.21110.ABSTRACTPopulations with common physical diseases - such as cardiovascular diseases, cancer and neurodegenerative disorders - experience substantially higher rates of major depressive disorder (MDD) than the general population. On the other hand, people living with MDD have a greater risk for many physical diseases. This high level of comorbidity is associated with worse outcomes, reduced adherence to treatment, increased mortality, and greater health care utilization and costs. Comorbidity can also result in a range of clinical challenges, such as a more com...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Michael Berk Ole K öhler-Forsberg Megan Turner Brenda W J H Penninx Anna Wrobel Joseph Firth Amy Loughman Nicola J Reavley John J McGrath Natalie C Momen Oleguer Plana-Ripoll Adrienne O'Neil Dan Siskind Lana J Williams Andre F Carvalho Lianne Schmaal Ada Source Type: research
Lead, Cadmium, and Arsenic in Raw Milk Produced in the Vicinity of a Mini Mineral Concentrator in the Central Andes and Health Risk
This study evaluated the potential risk to human health from lead (Pb), cadmium (Cd), and arsenic (As) from the consumption of milk produced in an area of the Central Andes valley near a mini mineral concentrator by estimating the weekly intake (WI), dietary risk quotient (DRC), hazard quotient (THQ), and hazard index (HI) for the Peruvian population aged 2 to 85 years, in three scenarios of milk consumption by age (minimum, average, and maximum). Toxic element quantification was performed by flame atomic absorption spectrometry following standardized procedures. The mean amount ± standard deviation of Pb, Cd, and As in s...
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Doris Chirinos-Peinado Jorge Castro-Bedri ñana Elva R íos-Ríos Gianfranco Castro-Chirinos Yubaly Quispe-Poma Source Type: research
Boosting thermophilic anaerobic digestion with conductive materials: Current outlook and future prospects
Chemosphere. 2023 Sep 13:140175. doi: 10.1016/j.chemosphere.2023.140175. Online ahead of print.ABSTRACTThermophilic anaerobic digestion (TAD) can provide superior process kinetics, higher methane yields, and more pathogen destruction than mesophilic anaerobic digestion (MAD). However, the broader application of TAD is still very limited, mainly due to process instabilities such as the accumulation of volatile fatty acids and ammonia inhibition in the digesters. An emerging technique to overcome the process disturbances in TAD and enhance the methane production rate is to add conductive materials (CMs) to the digester. Rece...
Source: Chemosphere - September 15, 2023 Category: Chemistry Authors: Monisha Alam Bipro Ranjan Dhar Source Type: research
Energy expenditure deficits drive obesity in a mouse model of Alstr öm syndrome
CONCLUSIONS: Either loss of ALMS1 causes a developmental delay in the mechanisms controlling early life EE or activation of compensatory mechanisms occurs after obesity is established in AS. Future studies will determine how ALMS1 modulates EE and how sex moderates this process.PMID:37712194 | DOI:10.1002/oby.23877
Source: Obesity - September 15, 2023 Category: Eating Disorders & Weight Management Authors: Erin J Stephenson Clint E Kinney Amanda S Stayton Joan C Han Source Type: research
Transcription factor-based biosensors for detection of naturally occurring phenolic acids
N Biotechnol. 2023 Sep 13:S1871-6784(23)00047-X. doi: 10.1016/j.nbt.2023.09.004. Online ahead of print.ABSTRACTPhenolic acids including hydroxybenzoic and hydroxycinnamic acids are secondary plant and fungal metabolites involved in many physiological processes offering health and dietary benefits. They are often utilised as precursors for production of value-added compounds. The limited availability of synthetic biology tools, such as whole-cell biosensors suitable for monitoring the dynamics of phenolic acids intracellularly and extracellularly, hinders the capabilities to develop high-throughput screens to study their me...
Source: New Biotechnology - September 15, 2023 Category: Biotechnology Authors: Ernesta Augustiniene Ingrida Kutraite Egle Valanciene Paulius Matulis Ilona Jonuskiene Naglis Malys Source Type: research
Different stimuli induce endothelial dysfunction and promote atherosclerosis through the Piezo1/YAP signaling axis
Arch Biochem Biophys. 2023 Sep 14;747:109755. doi: 10.1016/j.abb.2023.109755. Online ahead of print.ABSTRACTVascular endothelial dysfunction is the initial step in atherosclerosis (AS). AS tends to occur at vascular bifurcations and curves, and endothelial cells(ECs) are highly susceptible to injury due to mechanical forces induced by disturbed flow (DF) with inconsistent blood flow directions. However, the pathogenesis of endothelial cell dysfunction in AS remains unclear and needs further study. Here, we found that Piezo1 expression was significantly increased in DF- and oxidized low-density lipoprotein(ox-LDL)-treated H...
Source: Archives of Biochemistry and Biophysics - September 15, 2023 Category: Biochemistry Authors: Jingying Mao Ronghao Yang Ping Yuan Fei Wu Yan Wei Yongmei Nie Chunxiang Zhang Xiangyu Zhou Source Type: research
Glabridin ameliorates intracellular events caused by palmitic acid and alcohol in mouse hepatocytes and fast food diet and alcohol -induced steatohepatitis and fibrosis in C57BL/6J mice model
In conclusion, these findings suggest that GBD has a strong therapeutic potential to be developed as anti-steatohepatitis/fibrosis medicine.PMID:37714449 | DOI:10.1016/j.fct.2023.114038
Source: Food and Chemical Toxicology - September 15, 2023 Category: Food Science Authors: Raghu Rai Sharma Haroon Rashid Aalim Maqsood Bhat Archoo Sajida Ragni Gupta Sheikh Tasduq Abdullah Source Type: research
A high fat, high sugar diet induces hepatic Peroxisome proliferator-activated receptor gamma coactivator 1-alpha promoter hypermethylation in male Wistar rats
Biochem Biophys Res Commun. 2023 Sep 7;680:25-33. doi: 10.1016/j.bbrc.2023.09.004. Online ahead of print.ABSTRACTPreviously we reported that a high fat, high sugar (HFHS) diet induced adiposity, hyperinsulinaemia, hyperleptinaemia, hypertriglyceridaemia and increased liver mass in male Wistar rats. In the present study, the mechanisms underlying the increased liver mass were further elucidated by assessing hepatic lipid accumulation and the expression and methylation status of key metabolic genes using histology, quantitative real-time PCR and pyrosequencing, respectively. The HFHS diet induced hepatic steatosis, increased...
Source: Biochemical and Biophysical Research communications - September 15, 2023 Category: Biochemistry Authors: Yoonus Abrahams Tarryn Willmer Oelfah Patel Ebrahim Samodien Christo J F Muller Shantal Windvogel Rabia Johnson Carmen Pheiffer Source Type: research
Promoting plant-based eating in meat-centric meal contexts: a field study
CONCLUSIONS: A short-term, theory-driven, operationally feasible intervention was effective in promoting increased plant-based meal choices in a collective meal context. Nevertheless, these changes were not entirely sustained over time. Future studies could test whether prolonged or more transformative interventions are necessary to unlock entrenched food practices more effectively in meat-centric collective meal contexts.PMID:37712383 | DOI:10.1017/S1368980023001763
Source: Public Health Nutrition - September 15, 2023 Category: International Medicine & Public Health Authors: David Guedes Vasco Braz ão Lisa Roque L úcia Campos Cristina Godinho Monica Truninger Markus Vinnari Jo ão Graça Source Type: research
Enhancing stability of liposomes using high molecular weight chitosan to promote antioxidative stress effects and lipid-lowering activity of encapsulated lutein in vivo and in vitro
Int J Biol Macromol. 2023 Sep 13:126564. doi: 10.1016/j.ijbiomac.2023.126564. Online ahead of print.ABSTRACTLutein is an antioxidant with multiple beneficial functions. However, its therapeutic potential is hampered by its low water solubility and bioavailability. The goal of this study is to compare the stability of lutein-loaded liposomes (Lu-lip) and low (LC)/high molecular weight (HC) chitosan-coated Lu-lip, along with their antioxidant capacity using H2O2-induced HepG2 cells and their lipid-lowering activity using high-fat diet mice. Both LC and HC reduced the lutein degradation rate by 17.5 % and 26.72 % in a challen...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Gaoshuai Zhang Meijing Zhang Yiqiao Pei Kun Qian Jiao Xie Qun Huang Suwen Liu Na Xue Yujiao Zu Hao Wang Source Type: research
A transcriptomic study of osteoporosis induced by ketogenic diet in mice
CONCLUSION: The differentially expressed genes and enriched pathways identified in the mouse models provide new clues for studying the molecular mechanism and prevention of KD-induced osteoporosis.PMID:37712283 | PMC:PMC10505562 | DOI:10.12122/j.issn.1673-4254.2023.08.23
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Wu Y Fan Y Ye P Li Q Zhu Z Chen B Li W Wang L Zheng Source Type: research
Boosting thermophilic anaerobic digestion with conductive materials: Current outlook and future prospects
Chemosphere. 2023 Sep 13:140175. doi: 10.1016/j.chemosphere.2023.140175. Online ahead of print.ABSTRACTThermophilic anaerobic digestion (TAD) can provide superior process kinetics, higher methane yields, and more pathogen destruction than mesophilic anaerobic digestion (MAD). However, the broader application of TAD is still very limited, mainly due to process instabilities such as the accumulation of volatile fatty acids and ammonia inhibition in the digesters. An emerging technique to overcome the process disturbances in TAD and enhance the methane production rate is to add conductive materials (CMs) to the digester. Rece...
Source: Chemosphere - September 15, 2023 Category: Chemistry Authors: Monisha Alam Bipro Ranjan Dhar Source Type: research
< em > Erchen < /em > Decoction improves iron homeostasis in mice with non-alcoholic fatty liver disease by regulating iron transport capacity in the spleen
CONCLUSION: Erchen Decoction can alleviate high-fat diet-induced iron metabolism disorder by improving the iron ion transport ability of the spleen cells to delay the progression of NAFLD.PMID:37712264 | PMC:PMC10505571 | DOI:10.12122/j.issn.1673-4254.2023.08.04
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: G Deng H Jia Y Li J Li C Wu H Shi M Qin J Zhao C Liu Y Liao L Gao Source Type: research
