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Total 101973 results found since Jan 2013.

Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio
This study evaluated the role of mitochondria, which are maternally inherited, in the cross-generational toxicity of benzo(a)pyrene (BaP), a model PAH and known mitochondrial toxicant. Mature female zebrafish (F0) were fed diets containing 0, 12.5, 125, or 1250 μg BaP/g at a feed rate of 1% body weight twice/day for 21 days. These females were bred with unexposed males, and the embryos (F1) were collected for subsequent analyses. Maternally-exposed embryos exhibited altered mitochondrial function and metabolic partitioning (i.e. the portion of respiration attributable to different cellular processes), as evidenced by in v...
Source: Aquatic Toxicology - September 18, 2023 Category: Toxicology Authors: Jordan S Kozal Nishad Jayasundara Andrey Massarsky Casey D Lindberg Anthony N Oliveri Ellen M Cooper Edward D Levin Joel N Meyer Richard T Di Giulio Source Type: research

Efficacy of a gluten-free diet in reducing the widespread pain index and symptom severity scale in patients affected by fibromyalgia
CONCLUSIONS: A GFD improved FM symptoms evaluated with WPI and SS. This was confirmed for the first time, also with a rechallenge of the GFD that followed a non-restricted gluten-containing diet.PMID:37721353 | DOI:10.4081/reumatismo.2023.1530
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: V Bruzzese C Marrese P Scolieri J Pepe Source Type: research

High-Fat Ketogenic Diets and Ketone Monoester Supplements Differentially Affect Substrate Metabolism during Aerobic Exercise
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00359.2023. Online ahead of print.ABSTRACTChronically adhering to high-fat ketogenic diets or consuming ketone monoester supplements elicits ketosis. Resulting changes in substrate metabolism appear to be drastically different between ketogenic diets and ketone supplements. Consuming a ketogenic diet increases fatty acid oxidation with concomitant decreases in endogenous carbohydrate oxidation. Increased fat oxidation eventually results in an accumulation of circulating ketone bodies, which are metabolites of fatty acids that serve as an alternative source of fue...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Lee M Margolis Stefan M Pasiakos Emily E Howard Source Type: research

Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 18. doi: 10.1152/ajpregu.00137.2023. Online ahead of print.ABSTRACTPostnatal growth failure remains a significant problem for infants born prematurely, despite aggressive efforts to improve perinatal nutrition. Though often dysregulated in early life when children are born preterm, sodium (Na) homeostasis is vital to achieve optimal growth. We hypothesize that insufficient Na supply in this critical period contributes to growth restriction and programmed risks for cardiometabolic disease in later adulthood. Thus, we sought to ascertain the effects of prolonged versus early-l...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Alisha A Ziegler Samuel B R Lawton Connie C Grobe John J Reho Bonnie P Freudinger Colin M L Burnett Pablo Nakagawa Justin L Grobe Jeffrey L Segar Source Type: research

Integration of palliative care in the management of oral squamous cell carcinoma
Bioinformation. 2023 Jan 31;19(1):1-4. doi: 10.6026/97320630019001. eCollection 2023.ABSTRACTOral Squamous cell Cancers (OSCC) is strongly associated with tobacco consumption. We here in present a case study of a OSCC patient who refused standard oncological care (SOC), to highlight the importance of integrating palliative care (PC) for improved patient outcomes. A 61 years male patient, with history of chewing tobacco for more than 20 years and diagnosed to have OSCC for 1.5 years presented with severe anaemia and a cauliflower-like growth (12 x 10 cm) in the left oral cavity and cheek with greenish-yellow discharge. Pus ...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Republica Sridhar Huwait Etimad Peter Natesan Pushparaj Gauthaman Kalamegam Source Type: research

Awareness on weaning diet among mothers of under five children in North Gujarat
Bioinformation. 2023 Jan 31;19(1):32-34. doi: 10.6026/97320630019032. eCollection 2023.ABSTRACTMalnutrition caused by ineffective weaning techniques used during infancy and early childhood might affect cognitive and social development, school performance, and productivity in later life. The aim of the study was to evaluate the efficacy of education program in enhancing the awareness of mothers of under 5 children regarding weaning diet. The data was collected from 60 mothers of under 5 year's children. The existing awareness was assessed using a self-structured questionnaire. After pre intervention test, the mothers were p...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Mahalakshmi B Vaikunthbhai Solanki Pujaben Sivasubramanian N Shaijo Kj Source Type: research

Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary non-function of fatty liver allografts
Transl Res. 2023 Sep 16:S1931-5244(23)00146-9. doi: 10.1016/j.trsl.2023.09.006. Online ahead of print.ABSTRACTOrthotopic liver transplantation (OLT) is a lifesaving procedure. However, grafts may fail due to primary non-function (PNF). In the past, we demonstrated PNFs to be mainly associated with fatty allografts, and given its unpredictable nature, the development of a disease model is urgently needed. In an effort to investigate mechanism of fatty-allograft associated PNFs, we induced fatty liver disease in donor animals by feeding rats a diet deficient in methionine and choline (MCD). We performed OLT with allografts o...
Source: Translational Research : the journal of laboratory and clinical medicine - September 18, 2023 Category: Laboratory Medicine Authors: Ulf Kulik Caroline Moesta Reinhard Spanel J ürgen Borlak Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Chlorogenic acid enhances PPAR γ-mediated lipogenesis through preventing Lipin 1 nuclear translocation in Staphylococcus aureus-exposed bovine mammary epithelial cells
In this study, the internalization of S. aureus reduced intracellular lipid droplet formation, decreased the levels of intracellular triacylglycerol, total cholesterol and 7 types of fatty acid and downregulated the expression of lipogenic genes FAS, ACC, and DGAT1 in bovine mammary epithelial cells (BMECs). In addition, we found that S. aureus intracellular infection attenuated mTORC1 activation resulting in Lipin 1 nuclear localization. Remarkablely, S. aureus infection-mediated repression of lipid synthesis related to the mTORC1 signaling and Lipin 1 nuclear localization can be alleviated by CGA. Thus, our findings prov...
Source: Mol Biol Cell - September 17, 2023 Category: Molecular Biology Authors: Ruiyuan Yao Manshulin Wang Yue Zhao Qiang Ji Xue Feng Linfeng Bai Lili Bao Yanfeng Wang Huifang Hao Xihe Li Zhigang Wang Source Type: research

Impact of diet modification on body mass and kidney function in patients with diabetic nephropathy: a pilot study
CONCLUSIONS: The study shows that obesity is a common comorbid disease in patients with DN and that dietary intervention is associated with a significant reduction in body mass and stabilization of eGFR in these patients.PMID:37717272 | DOI:10.18388/abp.2020_6889
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Ma łgorzata Kaczkan Sylwia Czaja-Stolc Ma łgorzata Sikorska-Wiśniewska Micha ł Chmielewski Alicja D ębska-Ślizień Sylwia Ma łgorzewicz Source Type: research

Child characteristic correlates of food rejection in preschool children: A narrative review
Appetite. 2023 Sep 15:107044. doi: 10.1016/j.appet.2023.107044. Online ahead of print.ABSTRACTDietary habits formed in early childhood are key for establishing a healthy diet later in life. Picky eating and food neophobia - the two main forms of food rejection in young children - form an important barricade to establishing such healthy habits. Understanding these types of food rejection is thus essential for promoting healthy eating behaviour in both children and adults. To this end, the present narrative review aims to provide an overview of food rejection research in preschool-aged children, focusing on recent advances i...
Source: Appetite - September 17, 2023 Category: Nutrition Authors: Anouk J P van den Brand Anouk E M Hendriks-Hartensveld Remco C Havermans Chantal Nederkoorn Source Type: research

Chlorogenic acid enhances PPAR γ-mediated lipogenesis through preventing Lipin 1 nuclear translocation in Staphylococcus aureus-exposed bovine mammary epithelial cells
In this study, the internalization of S. aureus reduced intracellular lipid droplet formation, decreased the levels of intracellular triacylglycerol, total cholesterol and 7 types of fatty acid and downregulated the expression of lipogenic genes FAS, ACC, and DGAT1 in bovine mammary epithelial cells (BMECs). In addition, we found that S. aureus intracellular infection attenuated mTORC1 activation resulting in Lipin 1 nuclear localization. Remarkablely, S. aureus infection-mediated repression of lipid synthesis related to the mTORC1 signaling and Lipin 1 nuclear localization can be alleviated by CGA. Thus, our findings prov...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Ruiyuan Yao Manshulin Wang Yue Zhao Qiang Ji Xue Feng Linfeng Bai Lili Bao Yanfeng Wang Huifang Hao Xihe Li Zhigang Wang Source Type: research

Improvements in dietary intake, behaviors, and psychosocial measures in a community-randomized cardiovascular disease risk reduction intervention: Strong Hearts, Healthy Communities 2.0
CONCLUSIONS: SHHC-2.0 has strong potential to improve diet patterns and diet-related psychosocial wellbeing consistent with improved cardiovascular health. Registered at www.CLINICALTRIALS: gov on 23 February 2017 (NCT03059472).PMID:37717638 | DOI:10.1016/j.ajcnut.2023.09.003
Source: The American Journal of Clinical Nutrition - September 17, 2023 Category: Nutrition Authors: Alexandra L MacMillan Uribe Margaret Demment Meredith L Graham Jacob Szeszulski Chad D Rethorst Phrashiah Githinji Miriam E Nelson David Strogatz Sara C Folta Regan L Bailey Jaimie N Davis Rebecca A Seguin-Fowler Source Type: research

Irisin ameliorated skeletal muscle atrophy by inhibiting fatty acid oxidation and pyroptosis induced by palmitic acid in chronic kidney disease
CONCLUSION: our study firstly verifies that pyroptosis is a novel mechanism of skeletal muscle atrophy in CKD. Irisin ameliorated skeletal muscle atrophy by inhibiting FAO and pyroptosis in CKD, and Irisin may be developed as a potential therapeutic agent for the treatment of muscle wasting in CKD patients.PMID:37717561 | DOI:10.1159/000533926
Source: Cell Research - September 17, 2023 Category: Cytology Authors: Ting Zhou Shiyuan Wang Yajing Pan Xingtong Dong Leiyun Wu Jiali Meng Jialing Zhang Qi Pang Aihua Zhang Source Type: research