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Nutrition: Antidoxidants
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Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis
Braz J Med Biol Res. 2023 Sep 8;56:e12776. doi: 10.1590/1414-431X2023e12776. eCollection 2023.ABSTRACTMultiple sclerosis (MS), a neuroinflammation that results in neurodegeneration, is the most prevalent central nervous system inflammatory disease in young people. A diet rich in antioxidants is known to decrease the production/activity of pro-inflammatory cytokines and have a positive impact on the prognosis of MS. The purpose of this study was to assess if dietary antioxidant capacity is related to Expanded Disability Status Scale (EDSS) scores in patients with MS. Patients with MS (n=220; 137 women and 83 men) were asked...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: S Mungan I Guzel B C Demirdogen Source Type: research
Inactivation of Heterosigma akashiwo under UV/peroxydisulfate advanced disinfection system in marine waters
Chemosphere. 2023 Sep 11:140055. doi: 10.1016/j.chemosphere.2023.140055. Online ahead of print.ABSTRACTHeterosigma akashiwo (H. akashiwo) is recognized as a harmful algal bloom (HABs) species with a global distribution, capable of posing significant threats to marine ecosystems, particularly when spread through ship ballast water. This investigation focused on elucidating the inactivation kinetics and underlying mechanism of H. akashiwo through a combined ultraviolet irradiation and peroxydisulfate (UV/PDS) process. The results demonstrated a strong synergistic effect within the UV/PDS system, resulting in an inactivation ...
Source: Chemosphere - September 13, 2023 Category: Chemistry Authors: Xuan Chen Kunling Huang Pin Gan Lan Luo Kefu Yu Yuanyuan Zhang Yunfeng Pang Pengfei Xue Source Type: research
Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice
Biol Trace Elem Res. 2023 Sep 13. doi: 10.1007/s12011-023-03845-3. Online ahead of print.ABSTRACTOverdose of acetaminophen (paracetamol), a widely used non-prescriptive analgesic and antipyretic medication, is one of the main causes of drug-induced acute liver failure around the world. Oxidative stress contributes to this hepatotoxicity. Antioxidants are known to protect the liver from oxidative stress. Selenium, a potent antioxidant, is a commonly used micronutrient. Here, we evaluated the protective effect of selenium on acetaminophen-induced hepatotoxicity. Treating Wistar albino mice with sodium selenite (1 mg/kg) befo...
Source: Biological Trace Element Research - September 13, 2023 Category: Biology Authors: Mylanayakanahosahalli Chandrashekar Indumathi Kamatam Swetha Kandahalli Venkataranganayaka Abhilasha Shiva Siddappa Shivamadhaiah Manjula Kumar Govinda Keerthi Prasad Chu-Huang Chen Gopal Kedihithlu Marathe Source Type: research
Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1
Curr Vasc Pharmacol. 2023 Sep 12. doi: 10.2174/1570161121666230912155548. Online ahead of print.ABSTRACTCardiovascular (CV) disease (CVD) is a major cause of morbidity and mortality world-wide, thus it is important to adopt preventive interventions. Observational data demonstrating CV benefits of vitamin supplements, advanced by self-proclaimed experts have resulted in ~50% of Americans reporting the use of multivitamins for health promotion; this practice has led to a multi-billion-dollar business of the multivitamin-industry. However, the data on the extensive use of multivitamins show no consistent benefit for CVD preve...
Source: Current Vascular Pharmacology - September 13, 2023 Category: Drugs & Pharmacology Authors: Antonis A Manolis Theodora A Manolis Helen Melita Antonis S Manolis Source Type: research
Oxidative stress associated with proteomic and fatty acid profiles of sperm from Nellore bulls at rest
Biol Reprod. 2023 Sep 13:ioad121. doi: 10.1093/biolre/ioad121. Online ahead of print.ABSTRACTSexual rest is a transient condition, that compromises conception rates, characterized by large volumes of ejaculate with high percentages of dead sperm observed in bulls. The biochemical mechanisms leading to this ejaculate pattern are not fully understood. Six adult resting Nellore bulls were submitted to Breeding Soundness Evaluation by four consecutive semen collections through the electroejaculation method during a 30 min period. Each ejaculate had its semen phenotypic parameters, morphology and physical aspects, evaluated. To...
Source: Reproductive Biology - September 13, 2023 Category: Reproduction Medicine Authors: Camilo Jos é Ramírez-López Edvaldo Barros Pedro Marcus Vidigal Denise Okano Silva Lidiany Lopes Gomes Rener Philipe Rodrigues Carvalho Alex Gazolla Castro Maria Cristina Baracat-Pereira Simone Eliza Facioni Guimar ães Jos é Domingos Guimarães Source Type: research
Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase
In conclusion, KP provides hepatoprotective effects against oxidative stress induced by AA + iron treatment in vitro and CCl4 treatment in vivo.PMID:37703935 | DOI:10.1016/j.freeradbiomed.2023.09.008
Source: Free Radical Biology and Medicine - September 13, 2023 Category: Biology Authors: Min-Jin Kim Yu-Rim Song Young Eun Kim Su-Jin Bae Won-Yung Lee Seon-Been Bak Young Woo Kim Source Type: research
Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration
CONCLUSIONS: Moderate-certainty evidence suggests that antioxidant vitamin and mineral supplementation (AREDS: vitamin C, E, beta-carotene, and zinc) probably slows down progression to late AMD. People with intermediate AMD have a higher chance of benefiting from antioxidant supplements because their risk of progression is higher than people with early AMD. Although low-certainty evidence suggested little effect with lutein/zeaxanthin alone compared with placebo, exploratory subgroup analyses from one large American study support the view that lutein/zeaxanthin may be a suitable replacement for the beta-carotene used in th...
Source: Cochrane Database of Systematic Reviews - September 13, 2023 Category: General Medicine Authors: Jennifer R Evans John G Lawrenson Source Type: research
Oxidative stress associated with proteomic and fatty acid profiles of sperm from Nellore bulls at rest
Biol Reprod. 2023 Sep 13:ioad121. doi: 10.1093/biolre/ioad121. Online ahead of print.ABSTRACTSexual rest is a transient condition, that compromises conception rates, characterized by large volumes of ejaculate with high percentages of dead sperm observed in bulls. The biochemical mechanisms leading to this ejaculate pattern are not fully understood. Six adult resting Nellore bulls were submitted to Breeding Soundness Evaluation by four consecutive semen collections through the electroejaculation method during a 30 min period. Each ejaculate had its semen phenotypic parameters, morphology and physical aspects, evaluated. To...
Source: Biology of Reproduction - September 13, 2023 Category: Reproduction Medicine Authors: Camilo Jos é Ramírez-López Edvaldo Barros Pedro Marcus Vidigal Denise Okano Silva Lidiany Lopes Gomes Rener Philipe Rodrigues Carvalho Alex Gazolla Castro Maria Cristina Baracat-Pereira Simone Eliza Facioni Guimar ães Jos é Domingos Guimarães Source Type: research
Higher cadmium and zinc accumulation in parsley (Petroselinum crispum) roots activates its antioxidants defense system
Biometals. 2023 Sep 13. doi: 10.1007/s10534-023-00529-2. Online ahead of print.ABSTRACTParsley (Petroselinum crispum) is herb with many biological and medicinal benefits for humans. However, growth on zinc (Zn) and cadmium (Cd) contaminated sites might get severely affected due to over accumulation of heavy metals (HM) in different plant tissues. Antioxidants play a crucial role in minimizing the negative effects of HM. The present study investigates the effects of Zn and Cd stress on P. crispum morphological parameters, enzymatic/non-enzymatic antioxidant profiling and metal accumulation in shoot/root. Plants were exposed...
Source: Biometals - September 13, 2023 Category: Biochemistry Authors: Ismat Nawaz Atifa Mehboob Aqib Hassan Ali Khan Tatheer Alam Naqvi Nazneen Bangash Sadia Aziz Wajiha Khan Irum Shahzadi Roc ío Barros Kifayat Ullah Mohammad Maroof Shah Source Type: research
The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
CONCLUSIONS: Based on the spectroscopic and microcalorimetric data, both KAN and NEO can be considered modulators of the HSA antioxidant activity.PMID:37704832 | DOI:10.1007/s43440-023-00529-6
Source: Pharmacological Reports - September 13, 2023 Category: Drugs & Pharmacology Authors: Wojciech Rog óż Kinga Mac Aleksandra Owczarzy Karolina Kulig Jadwiga Po życka Ma łgorzata Maciążek-Jurczyk Source Type: research
Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1
Curr Vasc Pharmacol. 2023 Sep 12. doi: 10.2174/1570161121666230912155548. Online ahead of print.ABSTRACTCardiovascular (CV) disease (CVD) is a major cause of morbidity and mortality world-wide, thus it is important to adopt preventive interventions. Observational data demonstrating CV benefits of vitamin supplements, advanced by self-proclaimed experts have resulted in ~50% of Americans reporting the use of multivitamins for health promotion; this practice has led to a multi-billion-dollar business of the multivitamin-industry. However, the data on the extensive use of multivitamins show no consistent benefit for CVD preve...
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Antonis A Manolis Theodora A Manolis Helen Melita Antonis S Manolis Source Type: research
Nrf2: Therapeutic target of islet function protection in diabetes and islet transplantation
Biomed Pharmacother. 2023 Sep 11;167:115463. doi: 10.1016/j.biopha.2023.115463. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor 2 (Nrf2) has been reported as a major intracellular regulator of antioxidant stress, notably in islet β cells with low antioxidant enzyme content. Nrf2 is capable of regulating antioxidant function, while it can also regulate insulin secretion, proliferation, and differentiation of β cells, ER stress, as well as mitochondrial function. Thus, Nrf2 pharmacological activators have been employed in the laboratory for the treatment of diabetic mice. Islet cells are exposed to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Butian Wei Xin Zhang Jiwei Qian Zhe Tang Bo Zhang Source Type: research
Evaluation of the effects of zein incorporation on physical, mechanical, and biological properties of polyhydroxybutyrate electrospun scaffold for bone tissue engineering applications
This study aimed to blend zein with polyhydroxybutyrate (PHB) at 5, 10, and 15 wt%, fabricate scaffolds using electrospinning, and then characterize them. SEM and mechanical analysis identified the scaffold with 10 wt% zein (PHB-10Z) as the optimal sample. Incorporating 10 wt% zein reduced fiber diameter from 894 ± 122 to 531 ± 42 nm while increasing ultimate tensile strength and elongation at break by approximately 53 % and 89 %, respectively. FTIR proved zein's presence in the scaffolds and possible hydrogen bonding with PHB. TGA confirmed the miscibility of polymers. DSC and XRD analyses indicated lower crystallinity ...
Source: International Journal of Biological Macromolecules - September 13, 2023 Category: Biochemistry Authors: Saeid Ghasemi Afshin Alibabaie Reyhane Saberi Mahdie Esmaeili Dariush Semnani Saeed Karbasi Source Type: research
Oxidative stress in breast cancer after chemotherapy
Bioinformation. 2022 Dec 31;18(12):1141-1145. doi: 10.6026/973206300181141. eCollection 2022.ABSTRACTIt is of interest to evaluate the influence of breast cancer on oxidative stress, liver function tests, renal biomarkers, action of doxorubicin, cyclophosphamide and paclitaxel (AC-T) in the treatment and mechanism over altering the measured markers in breast cancer. Sixty histopathological confirmed cases of female patients suffering with breast carcinoma from the Department of Oncology at Omega Cancer Hospital, Visakhapatnam were included in the study. The investigation was performed in 3 groups: a control group containin...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Tejaswi Pullakanam Sri Phani Murugan Mannangatti Ramakrishna Nekkala Venkata Madhavi Bellala Ravi Shankar Bellala Vijayalakshmi Payala Source Type: research
Inactivation of Heterosigma akashiwo under UV/peroxydisulfate advanced disinfection system in marine waters
Chemosphere. 2023 Sep 11:140055. doi: 10.1016/j.chemosphere.2023.140055. Online ahead of print.ABSTRACTHeterosigma akashiwo (H. akashiwo) is recognized as a harmful algal bloom (HABs) species with a global distribution, capable of posing significant threats to marine ecosystems, particularly when spread through ship ballast water. This investigation focused on elucidating the inactivation kinetics and underlying mechanism of H. akashiwo through a combined ultraviolet irradiation and peroxydisulfate (UV/PDS) process. The results demonstrated a strong synergistic effect within the UV/PDS system, resulting in an inactivation ...
Source: Chemosphere - September 13, 2023 Category: Chemistry Authors: Xuan Chen Kunling Huang Pin Gan Lan Luo Kefu Yu Yuanyuan Zhang Yunfeng Pang Pengfei Xue Source Type: research
