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Nutrition: Antidoxidants
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Translocation of CdS nanoparticles in maize (Zea mays L.) plant and its effect on metabolic response
Chemosphere. 2023 Sep 14:140189. doi: 10.1016/j.chemosphere.2023.140189. Online ahead of print.ABSTRACTCadmium sulfide nanomaterials are of great concern because of their potential toxicity and unavoidable releases due to multiple commercial applications of nanoparticles (NPs). Commercial NPs act as mediators of damage to plant cells and pose potential toxicity to plants and human health. In the current study, investigated the phytotoxicology, absorption, translocation, antioxidant enzyme activity, and metabolic profiles of maize (Zea mays L.) seedlings exposed to different hydroponic treatments for fifteen days. The diffe...
Source: Chemosphere - September 16, 2023 Category: Chemistry Authors: Hameed Ullah Wang Zheng Yanqing Sheng Source Type: research
Resveratrol alleviates MSU-induced gouty arthritis in rats through inhibition of HIF-1 α- and NLRP3-derived IL-1β secretion in macrophages
This study demonstrated that resveratrol significantly improved the symptoms of acute gouty arthritis and its potential mechanism may be IL-1β reduction via HIF-1α modulation and inhibition of NLRP3 inflammasome activation. Our study might offer a novel sight for the treatment of gouty arthritis.PMID:37715438 | DOI:10.14715/cmb/2023.69.7.5
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yamen Wang Wei Li Tianhan Zhang Runmei Wang Tao Wang Qingyun Xie Meng Wei Source Type: research
Anti-oxidant, diabetic and inflammatory activities of alpinia calcarata roscoe extract
CONCLUSION: Our findings demonstrated that leaf oil was slightly more promising results than rhizome oil of AC extract,which was ultimately showed medicinal potential of secondary metabolites with antioxidant, diabetic/inflammatory activities. Further, Eoils of AC have a wide range of pharmacological potential and promising anti-diabetic effects.PMID:37715949 | DOI:10.1002/cbdv.202300970
Source: Chemistry and Biodiversity - September 16, 2023 Category: Biochemistry Authors: Naorem Manglembi Devi Sankaranarayanan Nagarajan Chingakham Brajakishor Singh Mohammad Mujahid Ali Khan Anish Khan Nisha Khan Mohamed H Mahmoud Hassan Fouad AbuZar Ansari Source Type: research
Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential
This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti-inflammatory, anti-micro...
Source: Chemistry and Biodiversity - September 16, 2023 Category: Biochemistry Authors: Muahmmad Ali Khan Dina M El-Kersh Md Shafiqul Islam Shams Ara Khan Hossam Kamli Chandan Sarkar Md Shimul Bhuia Tawhida Islam Manik Chandra Shill Glenda C Gobe Eda S önmez Gürer William N Setzer Javad Sharifi-Rad Muhammad Torequl Islam Source Type: research
Preventive effects of Capparis Spinose extract on experimental periodontitis in rats: a histopathological and biochemical study
This study aimed to assess the effectiveness of Capparis Spinose (CS) in preventing the initiation and progression of experimental periodontitis and to evaluate the effect of its on systemic oxidative stress in rats by experimental periodontitis model. Twenty-four male rats were equally divided into; Ligatured (L), non-ligatured (NL), and Ligatured with CS (11 days/day per 20 mg/kg) (LC) groups. Experimental periodontitis was induced with the silk suture technic. Alveolar bone loss was examined, and total antioxidant capacity(TAOC), total oxidant status(TOS), and oxidative stress index(OSI) were analyzed in rat serum. Alth...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Hasan G ündoğar Hakan Özdemir Zeynep Deniz Şahin İnan Source Type: research
Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds
Environ Res. 2023 Sep 14:117087. doi: 10.1016/j.envres.2023.117087. Online ahead of print.ABSTRACTHydrogels represent intricate three-dimensional polymeric structures, renowned for their compatibility with living systems and their ability to naturally degrade. These networks stand as promising and viable foundations for a range of biomedical uses. The practical feasibility of employing hydrogels in clinical trials has been well-demonstrated. Among the prevalent biomedical uses of hydrogels, a significant application arises in the context of wound healing. This intricate progression involves distinct phases of inflammation,...
Source: Environmental Research - September 16, 2023 Category: Environmental Health Authors: Pooya M Tehrany Parham Rahmanian Aryan Rezaee Golnaz Ranjbarpazuki Farima Sohrabi Fard Yasaman Asadollah Salmanpour Mohammad Arad Zandieh Ali Ranjbarpazuki Sajedeh Asghari Nazanin Javani Noushin Nabavi Amir Reza Aref Mehrdad Hashemi Mohsen Rashidi Afshin Source Type: research
Characterization and biological evaluation of a novel flavonoid-collagen antioxidant hydrogel with cytoprotective properties
J Biomed Mater Res B Appl Biomater. 2023 Sep 16. doi: 10.1002/jbm.b.35321. Online ahead of print.ABSTRACTReactive oxygen species (ROS) play a critical and important role during wound healing but excess ROS at the wound site can lead to cellular damage and sub-optimal healing. Minimizing oxidative damage to the wound site and any supplemental therapeutic cells can be achieved by delivering exogenous antioxidants. Collagen hydrogels are ideal wound care materials due to their biocompatibility, high water content, and porous, three-dimensional architecture. Yet, they lack the inherent antioxidant activity that could help miti...
Source: Biomed Res - September 16, 2023 Category: Research Authors: Danielle M Nalband Prottasha Sarker Saad A Khan Donald O Freytes Source Type: research
Txnrd3 knockout enhancement of lung injury induced by Ni exposure via the VEGF-VEGFR-2 axis and alleviation of this effect by melatonin
In conclusion, Ni causes lung injury by activating the VEGF-VEGFR-2 pathway and Txnrd3 knockout aggravates injury after Ni exposure.PMID:37716496 | DOI:10.1016/j.fct.2023.114032
Source: Food and Chemical Toxicology - September 16, 2023 Category: Food Science Authors: Pinnan Liu Yue Sun Senqiu Qiao Wenxue Ma Lihua Xu Yue Liu Xiaoxue Gai Qiaohan Liu Jingzeng Cai Ziwei Zhang Source Type: research
Effect of polysaccharides on conformational changes and functional properties of protein-polyphenol binary complexes: A comparative study
This study aimed to investigate the effect of different polysaccharides on the binding behavior and functional properties of soybean protein isolate (SPI)-quercetin (Que) complex. The binding behavior was assessed using multi-spectral technique with the Stern-Volmer equation, which confirmed the presence of static fluorescence quenching in Que and SPI. The addition of sodium alginate (SA) resulted in a reduction of the binding affinity between SPI and Que, while dextran (DX) exhibited some promoting effect. A slight blue shift was observed in amide I and amide II bands, indicating the presence of hydrophobic and electrosta...
Source: International Journal of Biological Macromolecules - September 16, 2023 Category: Biochemistry Authors: Zifan Zhang Taoran Li Yubo Zhang Juanjuan Shao Chengxiang Ye Hongwu Wang Beibei Zhu Yating Zhang Source Type: research
Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis
Chem Biol Interact. 2023 Sep 14:110713. doi: 10.1016/j.cbi.2023.110713. Online ahead of print.ABSTRACTMatrine (MT) is an alkaloid isolated from Sophora flavescens with various bioactivities and is widely used clinically. However, the broader its clinical use, the greater its toxicity concerns. We investigate the role of ferroptosis in MT-induced liver injury caused by an imbalance in the antioxidant pathway. Our results showed that MT could cause pathological changes in liver tissues and lead to a significant reduction in L02 cell viability. MT also reduced superoxide dismutase (SOD) and glutathione (GSH), increased malo...
Source: Chemico-Biological Interactions - September 16, 2023 Category: Molecular Biology Authors: Xi Wang Wenjing Zhu Miao Xing Haiyan Zhu Enqing Chen Jie Zhou Source Type: research
Translocation of CdS nanoparticles in maize (Zea mays L.) plant and its effect on metabolic response
Chemosphere. 2023 Sep 14:140189. doi: 10.1016/j.chemosphere.2023.140189. Online ahead of print.ABSTRACTCadmium sulfide nanomaterials are of great concern because of their potential toxicity and unavoidable releases due to multiple commercial applications of nanoparticles (NPs). Commercial NPs act as mediators of damage to plant cells and pose potential toxicity to plants and human health. In the current study, investigated the phytotoxicology, absorption, translocation, antioxidant enzyme activity, and metabolic profiles of maize (Zea mays L.) seedlings exposed to different hydroponic treatments for fifteen days. The diffe...
Source: Chemosphere - September 16, 2023 Category: Chemistry Authors: Hameed Ullah Wang Zheng Yanqing Sheng Source Type: research
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
Two-month period of 500 mg lecithin-based delivery form of quercetin daily dietary supplementation counterbalances chronic fatigue symptoms: A double-blind placebo controlled clinical trial
CONCLUSION: The quercetin supplementation counterbalances CF symptoms.PMID:37716119 | DOI:10.1016/j.biopha.2023.115453
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Mariangela Rondanelli Antonella Riva Giovanna Petrangolini Clara Gasparri Simone Perna Source Type: research
Curcumin protects against fenvalerate-induced neurotoxicity in zebrafish (Danio rerio) larvae through inhibition of oxidative stress
This study aimed to explore the mechanisms underlying FEN-induced neurotoxicity using the zebrafish (Danio rerio) model. We also investigated whether curcumin (CUR), a polyphenol antioxidant that exhibits neuroprotective properties, can prevent FEN-induced neurotoxicity. Here, zebrafish embryos were exposed to 0, 3.5, 7 and 14 μg/L of FEN from 4 to 96 h post fertilization (hpf) and neurotoxicity was assessed. Our results showed that FEN decreased the survival rate, heart rate, body length and spontaneous movement, and increased malformation rate. FEN caused neurobehavioral alterations, including decreased swimming distanc...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Jiansheng Zhu Mingtao Huang Chunlan Liu Jingyu Wang Li Zou Fan Yang Renfei Zhu Source Type: research
Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds
Environ Res. 2023 Sep 14:117087. doi: 10.1016/j.envres.2023.117087. Online ahead of print.ABSTRACTHydrogels represent intricate three-dimensional polymeric structures, renowned for their compatibility with living systems and their ability to naturally degrade. These networks stand as promising and viable foundations for a range of biomedical uses. The practical feasibility of employing hydrogels in clinical trials has been well-demonstrated. Among the prevalent biomedical uses of hydrogels, a significant application arises in the context of wound healing. This intricate progression involves distinct phases of inflammation,...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Pooya M Tehrany Parham Rahmanian Aryan Rezaee Golnaz Ranjbarpazuki Farima Sohrabi Fard Yasaman Asadollah Salmanpour Mohammad Arad Zandieh Ali Ranjbarpazuki Sajedeh Asghari Nazanin Javani Noushin Nabavi Amir Reza Aref Mehrdad Hashemi Mohsen Rashidi Afshin Source Type: research
