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Nutrition: Antidoxidants
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Climbazole causes cell apoptosis and lipidosis in the liver of grass carp
In this study, grass carp (Ctenopharyngodon idella) and liver cell lines (L8824 cells) were treated with climbazole at concentrations ranging from 0.2 to 20 μg/L for 42 days in vivo and 24 h in vitro to evaluate the effects on the liver, respectively. Pathological, biochemical, and gene transcription and expression analyses were conducted to examine the hepatotoxicity. Our results showed that climbazole significantly decreased the hepatosomatic index, caused cell apoptosis in vivo and in vitro, and finally accumulated lipids in the liver. Beside, climbazole increased ROS levels, reduced Nrf2 and Keap1 mRNA and protein lev...
Source: Aquatic Toxicology - September 18, 2023 Category: Toxicology Authors: Zhi-Jie Lu Wen-Jun Shi Fang-Zhou Gao Dong-Dong Ma Jin-Ge Zhang Si-Ying Li Xiao-Bing Long Qian-Qian Zhang Guang-Guo Ying Source Type: research
Folate conjugated nanomedicines for selective inhibition of mTOR signaling in polycystic kidneys at clinically relevant doses
Biomaterials. 2023 Sep 13;302:122329. doi: 10.1016/j.biomaterials.2023.122329. Online ahead of print.ABSTRACTAlthough rapamycin is a very effective drug for rodents with polycystic kidney disease (PKD), it is not encouraging in the clinical trials due to the suboptimal dosages compelled by the off-target side effects. We here report the generation, characterization, specificity, functionality, pharmacokinetic, pharmacodynamic and toxicology profiles of novel polycystic kidney-specific-targeting nanoparticles (NPs). We formulated folate-conjugated PLGA-PEG NPs, which can be loaded with multiple drugs, including rapamycin (a...
Source: Biomaterials - September 18, 2023 Category: Materials Science Authors: Rajasekharreddy Pala Ayan K Barui Ashraf M Mohieldin Jing Zhou Surya M Nauli Source Type: research
Oxidative stress may be a contributing factor in fibromyalgia patients' pain mechanisms
CONCLUSIONS: Reactive oxygen species have several negative impacts on the human body. As a result of the measurements we analyzed, the relationship between FM and oxidative stress should be studied in terms of disease progression and may help improve the treatment process.PMID:37721351 | DOI:10.4081/reumatismo.2023.1550
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: H Beyaztas S Aktas E M Guler E Ata Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
In silico and in vitro evaluation of a safety profile of a cosmetic ingredient: 4-methoxychalcone (4-MC)
Toxicol In Vitro. 2023 Sep 16:105696. doi: 10.1016/j.tiv.2023.105696. Online ahead of print.ABSTRACTChalcone is an important scaffold within medicinal and cosmetic chemistry. The structure enables multiple modifications which may result in obtaining compounds with desirable bioactivity. One of the chalcone derivatives, 4-methoxychalcone is a known cosmetic ingredient indexed in Cosing database as an antioxidant, bleaching, and skin conditioning substance. We investigated its in silico and in vitro safety profile. In silico study using Derek Nexus showed its potential of skin sensitisation, equivocal nature of chromosome da...
Source: Toxicology in Vitro - September 18, 2023 Category: Toxicology Authors: Agnieszka Gunia-Krzy żak Justyna Popi ół Karolina S łoczyńska Dorota Żelaszczyk Katarzyna Orze ł Paulina Koczurkiewicz-Adamczyk Katarzyna W ójcik-Pszczoła Patryk Kasza Magda Borczuch-Kosta ńska El żbieta Pękala Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
Application of nanoparticles in Dentistry
Bioinformation. 2023 Jan 31;19(1):14-18. doi: 10.6026/97320630019014. eCollection 2023.ABSTRACTNanoparticles(NPs) are of particle sizes lesser than 100nm and are insoluble the field which deal with the handling of these particles is coined as "Nanotechnology" as their particle size is smaller, they can penetrate easily therefore they are applied in various medical fields, drug delivery and in dentistry as they have antimicrobial property, reduces friction, anti-inflammatory and antioxidant property. Many studies have been done to evaluate its application and its cytotoxicity by varying its concentration and various studies...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Sheloni Missier Mary Mahesh Ramakrishnan Saravana Dinesh Sudalaimani Paulpandian Shanmugam Rajeshkumar Jebilla Pringle Source Type: research
Folate conjugated nanomedicines for selective inhibition of mTOR signaling in polycystic kidneys at clinically relevant doses
Biomaterials. 2023 Sep 13;302:122329. doi: 10.1016/j.biomaterials.2023.122329. Online ahead of print.ABSTRACTAlthough rapamycin is a very effective drug for rodents with polycystic kidney disease (PKD), it is not encouraging in the clinical trials due to the suboptimal dosages compelled by the off-target side effects. We here report the generation, characterization, specificity, functionality, pharmacokinetic, pharmacodynamic and toxicology profiles of novel polycystic kidney-specific-targeting nanoparticles (NPs). We formulated folate-conjugated PLGA-PEG NPs, which can be loaded with multiple drugs, including rapamycin (a...
Source: Biomaterials - September 18, 2023 Category: Materials Science Authors: Rajasekharreddy Pala Ayan K Barui Ashraf M Mohieldin Jing Zhou Surya M Nauli Source Type: research
Tubulin as a potential molecular target for resveratrol in Giardia lamblia trophozoites, in vitro and in silico approaches
Acta Trop. 2023 Sep 16:107026. doi: 10.1016/j.actatropica.2023.107026. Online ahead of print.ABSTRACTGiardia lamblia is a globally distributed protozoan parasite that causes intestinal disease. Recently, there is an increase in refractory cases of giardiasis to chemotherapeutic agents, and drugs available cause side effects that may limit its use or cause therapeutic non-compliance. Therefore, search for alternative and less harmful drugs to treat giardiasis is an important task. In this sense, resveratrol (RSV) is a polyphenol with a wide range of pharmacological effects such as antimicrobial, anticarcinogenic and antioxi...
Source: Acta Tropica - September 18, 2023 Category: Infectious Diseases Authors: Jos é Roberto Vargas-Villanueva Filiberto Guti érrez-Gutiérrez Mariana Garza-Ontiveros Sendar Daniel Nery-Flores Lizeth Guadalupe Campos-M úzquiz Dagoberto Vazquez-Obreg ón Raul Rodriguez-Herrera Lissethe Palomo-Ligas Source Type: research
BALB/c and C57BL/6 mice differ in oxidant and antioxidant responses in innate and adaptive immune cells in an asthma model induced by cockroach allergens
Int Immunopharmacol. 2023 Sep 15;124(Pt B):110892. doi: 10.1016/j.intimp.2023.110892. Online ahead of print.ABSTRACTAsthma is a complex and heterogenous disease affected by a multitude of factors. Several phenotypes of asthma exist which are influenced by various molecular mechanisms that include presence of antioxidant and oxidant enzymes in different immune cells such as dendritic cells (DCs), alveolar macrophages (AMs), neutrophils, and T cells. Close interaction between epithelial cells and dendritic cells initiates complex pathogenesis of asthma followed by involvement of other innate and adaptive immune cells. In chr...
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Layla A Al-Kharashi Saleh A Alqarni Sheikh F Ahmad Naif O Al-Harbi Sary Alsanea Khalid E Ibrahim Mohammad M Algahtani Khalid Alhazzani Gamal A Shazly Mohammad M Al-Harbi Ahmed Nadeem Source Type: research
Current appraises of therapeutic applications of nanocurcumin: A novel drug delivery approach for biomaterials in dentistry
Environ Res. 2023 Sep 15:116971. doi: 10.1016/j.envres.2023.116971. Online ahead of print.ABSTRACTCurcumin is a natural herb and polyphenol that is obtained from the medicinal plant Curcuma longa. It's anti-bacterial, anti-inflammatory, anti-cancer, anti-mutagenic, antioxidant and antifungal properties can be leveraged to treat a myriad of oral and systemic diseases. However, natural curcumin has weak solubility, limited bioavailability and undergoes rapid degradation, which severely limits its therapeutic potential. To overcome these drawbacks, nanocurcumin (nCur) formulations have been developed for improved biomaterial ...
Source: Environmental Research - September 17, 2023 Category: Environmental Health Authors: Ranjeet A Bapat Sumit V Bedia Aarti S Bedia Ho Jan Yang Suyog Dharmadhikari Anshad Mohamed Abdulla Tanay V Chaubal Prachi R Bapat Shahabe Saquib Abullais Shadma Wahab Prashant Kesharwani Source Type: research
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00636-6. doi: 10.1016/j.freeradbiomed.2023.09.012. Online ahead of print.ABSTRACTFerroptosis is a novel form of cell death that plays a critical role in the pathological and physiological processes of early brain injury following subarachnoid hemorrhage. Melatonin, as the most potent endogenous antioxidant, has shown strong protective effects against pathological changes following subarachnoid hemorrhage, but its impact on ferroptosis induced by subarachnoid hemorrhage remains unexplored. In our study, we established a subarachnoid hemorrhage model in male SD rats. We found th...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Sheng-Ji Ma Chen Li Cong Yan Nan Liu Guang-You Jiang Hong-Rui Yang Hao-Chen Yan Ji-Yi Li Huai-Lei Liu Cheng Gao Source Type: research
Asiatic acid protects against pressure overload-induced heart failure in mice by inhibiting mitochondria-dependent apoptosis
CONCLUSIONS: Our findings suggest that AA effectively combats chronic TAC-induced and hydrogen peroxide-induced cardiomyocyte apoptosis through a mitochondria-dependent mechanism. AA reduces cellular levels of oxidative stress and inhibits the activation of the JNK pathway, highlighting its potential therapeutic value in the treatment of HF.PMID:37717794 | DOI:10.1016/j.freeradbiomed.2023.09.015
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Junjie Du Dongmin Yu Jinghang Li Linjie Si Dawei Zhu Ben Li Yizhou Gao Lifu Sun Xufeng Wang Xiaowei Wang Source Type: research
Life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in antioxidative status, ion regulation and histology of zebrafish gills
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 15:109746. doi: 10.1016/j.cbpc.2023.109746. Online ahead of print.ABSTRACTTris (2-chloroethyl) phosphate (TCEP) has been receiving great concerns owing to its ubiquitous occurrence in various environmental compartments and potential risks to wildlife and humans. Gill is structural basis for ion regulation and homeostasis in fish and susceptible to xenobiotics. However, current knowledge on the impacts of long-term exposure to TCEP on the structure and physiological function of fish gills are insufficient. In this work, zebrafish were exposed to environmental realistic conc...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 17, 2023 Category: Biochemistry Authors: Hangke Peng Hongkai Wang Wen Li Chen Jing Weiwei Zhang Haocheng Zhao Fengxiao Hu Source Type: research
Transcranial photobiomodulation mitigates learning and memory impairments induced by hindlimb unloading in a mouse model of microgravity exposure by suppression of oxidative stress and neuroinflammation signaling pathways
Brain Res. 2023 Sep 15:148583. doi: 10.1016/j.brainres.2023.148583. Online ahead of print.ABSTRACTProlonged microgravity exposure causes cognitive impairment. Evidence shows that oxidative stress and neuroinflammation are involved in the causation. Here, we explore the effectiveness of transcranial near-infrared photobiomodulation (PBM) on cognitive deficits in a mouse model of simulated microgravity. 24 adult male C57BL/6 mice were assigned into three groups (8 in each); control, hindlimb unloading (HU), and HU+PBM groups. After surgery to fit the suspension fixing, the animals were housed either in HU cages or in their n...
Source: Brain Research - September 17, 2023 Category: Neurology Authors: Sareh Kazmi Fereshteh Farajdokht Reza Meynaghizadeh-Zargar Saeed Sadigh-Eteghad Amir Pasokh Mohammad Farzipour Narmin Farazi Michael R Hamblin Javad Mahmoudi Source Type: research
