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Vaccination: Malaria Vaccine

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Total 1513 results found since Jan 2013.

Antenatal interventions to reduce risk of low birth weight related to maternal infections during pregnancy
CONCLUSIONS: At present, there is limited evidence from RCTs available for some potentially relevant interventions targeting maternal infections, which could be prioritized for future research.PMID:37331759 | DOI:10.1016/j.ajcnut.2023.02.025
Source: Am J Clin Nutr - June 18, 2023 Category: Nutrition Authors: Yvonne Muthiani Patricia J Hunter Pieta K N äsänen-Gilmore Annariina M Koivu Jaana Isoj ärvi Juho Luoma Meeri Salenius Maryam Hadji Ulla Ashorn Per Ashorn Source Type: research

Genetic diversity and molecular evolution of Plasmodium vivax Duffy Binding Protein and merozoite surface protein-1 in northwestern Thailand
This study aimed to use amplicon sequencing to investigate the genotypic patterns and population structure of P. vivax isolates from a highly endemic province of Thailand in recent years. Amplicon deep sequencing was performed on 70 samples for the 42-kDa region of pvmsp1 and domain II of pvdbp. Unique haplotypes were identified and a network constructed to illustrate genetic relatedness in northwestern Thailand. Based on this dataset of 70 samples collected between 2015 and 2021, 16 and 40 unique haplotypes were identified in pvdbpII and pvmsp142kDa, respectively. Nucleotide diversity was higher in pvmsp142kDa than in pvd...
Source: Infection, Genetics and Evolution - June 17, 2023 Category: Genetics & Stem Cells Authors: Parsakorn Tapaopong Gustavo da Silva Sittinont Chainarin Chayanut Suansomjit Khajohnpong Manopwisedjaroen Liwang Cui Cristian Koepfli Jetsumon Sattabongkot Wang Nguitragool Source Type: research

Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria therapeutics
Eur J Med Chem. 2023 Jun 12;258:115564. doi: 10.1016/j.ejmech.2023.115564. Online ahead of print.ABSTRACTMalaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the currently used antimalarials are the major challenges to malaria eradication efforts. To design and develop novel antimalarials, we synthesized a series of 4,7-dichloroquinoline and methyltriazolopyrimidine analogues using a multi-component Petasis reaction. The synthesized molecules (11-31) were screened for in-vitro antimalarial activity ag...
Source: European Journal of Medicinal Chemistry - June 15, 2023 Category: Chemistry Authors: Hari Madhav Tarosh S Patel Zeba Rizvi G Srinivas Reddy Abdur Rahman Md Ataur Rahman Saiema Ahmedi Sadaf Fatima Kanika Saxena Nikhat Manzoor Souvik Bhattacharjee Bharat C Dixit Puran Singh Sijwali Nasimul Hoda Source Type: research

Acceptance, availability, and feasibility of RTS, S/AS01 malaria vaccine: A review
ConclusionSeveral challenges need to be addressed to ensure the success of vaccination programs. From the acceptability perspective, issues such as inadequate community engagement, concerns about side effects, and issues with the delivery and quality of healthcare services can affect the acceptance of the vaccine. From the feasibility standpoint, factors such as lack of transportation or long distances to healthcare facilities and the perception of completion of the vaccination calendar can affect the feasibility of the vaccine. Lastly, the availability of the vaccine is also a major concern as it may not be readily availa...
Source: Immunity, Inflammation and Disease - June 14, 2023 Category: Allergy & Immunology Authors: Hassan Mumtaz, Abdullah Nadeem, Wajeeha Bilal, Farrukh Ansar, Saira Saleem, Qaisar Ali Khan, Tamara Tango, Christopher Farkouh, Naod F. Belay, Ravina Verma, Matthew Farkouh, Muhammad Saqib Tags: REVIEW ARTICLE Source Type: research

Biomimetic Nanovaccines: a Novel Approach in Immunization
Curr Pharm Des. 2023 May 29. doi: 10.2174/1381612829666230529094128. Online ahead of print.ABSTRACTAs the World Health Organization (WHO) declared, vaccines prevent an average of 2-3 million deaths yearly from diseases. However, effective prophylactic and therapeutic vaccines have yet to be developed for eradicating the deadliest diseases, viz., types of cancer, malaria, human immunodeficiency virus (HIV), and most serious microbial infections. Furthermore, scores of the existing vaccines have disadvantages, such as failure to completely stimulate the immune system, in vivo instability, high toxicity, need for the cold cha...
Source: Current Pharmaceutical Design - May 31, 2023 Category: Drugs & Pharmacology Authors: Javad Yaghmoorian Khojini Benjamin Babaei Maryam Shakarami Mahdis Mofidi Zahra Tahershamsi Tahura Fayeghi Arjmand Amir Tajbakhsh Seyed Mohammad Gheibihayat Source Type: research

The new malaria vaccine: A complementary approach, not a replacement for existing measures
Trop Doct. 2023 May 29:494755231178853. doi: 10.1177/00494755231178853. Online ahead of print.NO ABSTRACTPMID:37248616 | DOI:10.1177/00494755231178853
Source: Tropical Doctor - May 30, 2023 Category: Tropical Medicine Authors: Abdulrakib Abdulrahim Bashar Haruna Gulumbe Source Type: research

Clinical evaluation of commercial SARS-CoV-2 serological assays in a malaria endemic setting
J Immunol Methods. 2023 May 11:113488. doi: 10.1016/j.jim.2023.113488. Online ahead of print.ABSTRACTThe levels of immune response to SARS-CoV-2 infection or vaccination are poorly understood in African populations and is complicated by cross-reactivity to endemic pathogens as well as differences in host responsiveness. To begin to determine the best approach to minimize false positive antibody levels to SARS-CoV-2 in an African population, we evaluated three commercial assays, namely Bio-Rad Platelia SARS-CoV-2 Total Antibody (Platelia), Quanterix Simoa Semi-Quantitative SARS-CoV-2 IgG Antibody Test (anti-Spike), and the ...
Source: Journal of Immunological Methods - May 13, 2023 Category: Allergy & Immunology Authors: Djeneba Dabitao Kathryn Shaw-Saliba Drissa S Konate Helene C Highbarger Perrine Lallemand Ibrahim Sanogo Tauseef Rehman Mamadou Wague Nadie Coulibaly Bourahima Kone Bocar Baya Seidina A S Diakite Seydou Samake Esther Akpa Moctar Tounkara Sylvain Laverdure Source Type: research

The most prominent modulated annexins during parasitic infections
Acta Trop. 2023 May 10:106942. doi: 10.1016/j.actatropica.2023.106942. Online ahead of print.ABSTRACTAnnexins (ANXs) exert different functions in cell biological and pathological processes and are thus known as double or multi-faceted proteins. These sophisticated proteins might express on both parasite structure and secretion and in parasite-infected host cells. In addition to the characterization of these pivotal proteins, describing their mechanism of action can be also fruitful in recognizing their roles in the pathogenesis of parasitic infections. Accordingly, this study presents the most prominent ANXs thus far ident...
Source: Acta Tropica - May 12, 2023 Category: Infectious Diseases Authors: Sajad Rashidi Reza Mansouri Mohammad Ali-Hassanzadeh Antonio Muro Paul Nguewa Ra úl Manzano-Román Source Type: research

Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults
Am J Trop Med Hyg. 2023 May 9:tpmd220773. doi: 10.4269/ajtmh.22-0773. Online ahead of print.ABSTRACTThe radiation-attenuated Plasmodium falciparum sporozoites (PfSPZ) Vaccine has demonstrated safety and immunogenicity in 5-month-old to 50-year-old Africans in multiple trials. Except for one, each trial has restricted enrollment to either infants and children or adults < 50 years old. This trial was conducted in Equatorial Guinea and assessed the safety, tolerability, and immunogenicity of three direct venous inoculations of 1.8 × 106 or 2.7 × 106 PfSPZ, of PfSPZ Vaccine, or normal saline administered at 8-week interva...
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Said A Jongo Vicente Urbano Nsue Ndong Nchama L W Preston Church Ally Olotu Stephen R Manock Tobias Schindler Ali Mtoro Natasha Kc Orrin Devinsky Elcin Zan Ali Hamad Elizabeth Nyakarungu Maxmillian Mpina Anna Deal Jos é Raso Bijeri Martin Eka Ondo Mangue Source Type: research