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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Genetically modified malaria parasites as vaccine candidates
Trends Mol Med. 2022 Nov 17:S1471-4914(22)00295-7. doi: 10.1016/j.molmed.2022.11.005. Online ahead of print.ABSTRACTInduction of sterile immunity against sporozoite and liver stages of malaria is a long-standing aim in vaccine development. Genetically engineered, attenuated sporozoites were systematically evaluated in animal models. Murphy et al. present the first, promising clinical trial of early arresting parasites, PfGAP3KO, confirming safety and demonstrating efficacy against homologous challenge.PMID:36404198 | DOI:10.1016/j.molmed.2022.11.005
Source: Trends in Molecular Medicine - November 20, 2022 Category: Molecular Biology Authors: Claudia Daubenberger Source Type: research
10 What can we learn from the nervous sequelae of past pandemics?
Dr Mark Honigsbaum, medical historian and senior lecturer, City University of London. A regular contributor to The Observer & The Lancet, the author of five books including The Pandemic Century: One Hundred Years of Panic, Hysteria, and Hubris (New York and London: Norton; Hurst, 2019), The Fever Trail: In Search of the Cure for Malaria (Farrar Straus Giroux, 2002), and Living With Enza: The Forgotten Story of Britain and the Great Flu Pandemic of 1918 (Macmillan, 2009), which was longlisted for the Royal Society science book of the year in 2009. A specialist in the history of pandemics and infectious disease, his acad...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2022 Category: Neurosurgery Authors: Honigsbaum, M. Tags: Speakers Short Biographies and Abstracts Source Type: research
Current approaches to malaria vaccines
Curr Opin Microbiol. 2022 Nov 4;70:102227. doi: 10.1016/j.mib.2022.102227. Online ahead of print.ABSTRACTThe complex Plasmodium life cycle offers different vaccine approaches with distinct parasitological and clinical effects. The approaches and their rationales were established decades ago: vaccines targeting pre-erythrocytic (sporozoite and liver-stage) parasites prevent infection, those to blood-stage parasites reduce disease, and those to sexual-stage parasites or mosquito vector reduce transmission and eliminate malaria through herd immunity. The pre-erythrocytic RTS,S vaccine (Mosquirix, GlaskoSmithKline (GSK)), reco...
Source: Current Opinion in Microbiology - November 7, 2022 Category: Microbiology Authors: Patrick E Duffy Source Type: research
Computational Clues of Immunogenic Hotspots in < em > Plasmodium falciparum < /em > Erythrocytic Stage Vaccine Candidate Antigens: In Silico Approach
Biomed Res Int. 2022 Oct 13;2022:5886687. doi: 10.1155/2022/5886687. eCollection 2022.ABSTRACTMalaria is the most pernicious parasitic infection, and Plasmodium falciparum is the most virulent species with substantial morbidity and mortality worldwide. The present in silico investigation was performed to reveal the biophysical characteristics and immunogenic epitopes of the 14 blood-stage proteins of the P. falciparum using comprehensive immunoinformatics approaches. For this aim, various web servers were employed to predict subcellular localization, antigenicity, allergenicity, solubility, physicochemical properties, post...
Source: Biomed Res - October 24, 2022 Category: Research Authors: Mojtaba Azimi-Resketi Saeed Heydaryan Niloufar Kumar Azin Takalou Reza Esmaeelzadeh Dizaji Bahman Noroozi Gorgani Morteza Shams Source Type: research
Understanding the Intransigence of Malaria in Malawi
Am J Trop Med Hyg. 2022 Oct 11;107(4_Suppl):40-48. doi: 10.4269/ajtmh.21-1263. Print 2022 Oct 11.ABSTRACTDespite the scale-up of interventions against malaria over the past decade, this disease remains a leading threat to health in Malawi. To evaluate the epidemiology of both Plasmodium falciparum infection and malaria disease, the Malawi International Center of Excellence for Malaria Research (ICEMR) has developed and implemented diverse and robust surveillance and research projects. Descriptive studies in ICEMR Phase 1 increased our understanding of the declining effectiveness of long-lasting insecticidal nets (LLINs), t...
Source: Am J Trop Med Hyg - October 13, 2022 Category: Infectious Diseases Authors: Lauren M Cohee Jessy Goupeyou-Youmsi Karl B Seydel Charles Mangani Peter Ntenda Alick Sixpence Rex B Mbewe Alfred Matengeni Shannon Takala-Harrison Edward D Walker Mark L Wilson Themba Mzilahowa Miriam K Laufer Clarissa Valim Terrie E Taylor Don P Mathang Source Type: research
