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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Pneumococcal Vaccine, Polymyalgia Rheumatica, Giant Cell Arteritis, Concussion, Malaria
Am Fam Physician. 2023 Mar;107(3):230.NO ABSTRACTPMID:36920809
Source: American Family Physician - March 15, 2023 Category: Primary Care Source Type: research
Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines
Cell Mol Life Sci. 2023 Feb 27;80(3):74. doi: 10.1007/s00018-023-04712-z.ABSTRACTPlasmodium falciparum and P. vivax are the major causes of human malaria, and P. knowlesi is an important additional cause in SE Asia. Binding of apical membrane antigen 1 (AMA1) to rhoptry neck protein 2 (RON2) was thought to be essential for merozoite invasion of erythrocytes by Plasmodium spp. Our findings reveal that P. falciparum and P. vivax have diverged and show species-specific binding of AMA1 to RON2, determined by a β-hairpin loop in RON2 and specific residues in AMA1 Loop1E. In contrast, cross-species binding of AMA1 to RON2 is re...
Source: Cellular and Molecular Life Sciences : CMLS - February 27, 2023 Category: Cytology Authors: Damien R Drew Danny W Wilson Gretchen E Weiss Lee M Yeoh Isabelle G Henshall Brendan S Crabb Sheetij Dutta Paul R Gilson James G Beeson Source Type: research
CRISPR/Cas advancements for genome editing, diagnosis, therapeutics, and vaccine development for Plasmodium parasites, and genetic engineering of Anopheles mosquito vector
Infect Genet Evol. 2023 Feb 24;109:105419. doi: 10.1016/j.meegid.2023.105419. Online ahead of print.ABSTRACTMalaria as vector-borne disease remains important health concern with over 200 million cases globally. Novel antimalarial medicines and more effective vaccines must be developed to eliminate and eradicate malaria. Appraisal of preceding genome editing approaches confirmed the CRISPR/Cas nuclease system as a novel proficient genome editing system and a tool for species-specific diagnosis, and drug resistance researches for Plasmodium species, and gene drive to control Anopheles population. CRISPR/Cas technology, as a ...
Source: Infection, Genetics and Evolution - February 26, 2023 Category: Genetics & Stem Cells Authors: Leila Nourani Akram Abouie Mehrizi Sakineh Pirahmadi Zeinab Pourhashem Elahe Asadollahi Babak Jahangiri Source Type: research
Genetic variations of Plasmodium falciparum circumsporozoite protein and the impact on interactions with human immunoproteins and malaria vaccine efficacy
This study examined polyclonal infections and the associations of parasite genetic variations with binding affinity to human leukocyte antigen (HLA). Multiplicity of infection was determined by amplicon deep sequencing of PfMSP1. Genetic variations in PfCSP were examined across 88 samples from Ghana and analyzed together with 1655 PfCSP sequences from other African and non-African isolates. Binding interactions of PfCSP peptide variants and HLA were predicted using NetChop and HADDOCK. High polyclonality was detected among infections, with each infection harboring multiple non-3D7 PfCSP variants. Twenty-seven PfCSP haploty...
Source: Infection, Genetics and Evolution - February 25, 2023 Category: Genetics & Stem Cells Authors: Cheikh Cambel Dieng Colby T Ford Anita Lerch Dickson Doniou Kovidh Vegesna Daniel Janies Liwang Cui Linda Amoah Yaw Afrane Eugenia Lo Source Type: research
Meeting Summary: Global Vaccine and Immunization Research Forum, 2021
Vaccine. 2023 Feb 18:S0264-410X(23)00163-9. doi: 10.1016/j.vaccine.2023.02.028. Online ahead of print.ABSTRACTThe 2021 Global Vaccine and Immunization Research Forum highlighted the considerable advances and recent progress in research and development for vaccines and immunization, critically reviewed lessons learned from COVID-19 vaccine programs, and looked ahead to opportunities for this decade. For COVID-19, decades of investments in basic and translational research, new technology platforms, and vaccines targeting prototype pathogens enabled a rapid, global response. Unprecedented global coordination and partnership h...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Andrew Ford Angela Hwang Annie X Mo Shahida Baqar Nancy Touchette Carolyn Deal Deborah King Kristen Earle Birgitte Giersing Peter Dull B Fenton Hall Source Type: research
A novel high throughput plate-based method for 2-PE quantification in novel multidose vaccines (R21 malaria, Covishield and Covovax) and combination vaccines (Hexavalent)
Vaccine. 2023 Feb 17:S0264-410X(23)00174-3. doi: 10.1016/j.vaccine.2023.02.039. Online ahead of print.ABSTRACTMultidose presentation of vaccines is the most preferred choice, for mass immunization particularly during pandemics. WHO also recommends multidose containers of fill finished vaccines for programmatic suitability and global immunizations programmes. However, multidose vaccine presentations requires inclusion of preservatives to prevent contaminations. 2-Phenoxy ethanol (2-PE) is one such preservative which is being used in numerous cosmetics and many vaccines recently. Estimation of 2-PE content in multidose vials...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Dnyanesh Ranade Rajender Jena Kundan Patil Vikas Dogar Shubham Sancheti Vicky Deore Siddharam Ashtagi Sunil Gairola Source Type: research
Meeting Summary: Global Vaccine and Immunization Research Forum, 2021
Vaccine. 2023 Feb 18:S0264-410X(23)00163-9. doi: 10.1016/j.vaccine.2023.02.028. Online ahead of print.ABSTRACTThe 2021 Global Vaccine and Immunization Research Forum highlighted the considerable advances and recent progress in research and development for vaccines and immunization, critically reviewed lessons learned from COVID-19 vaccine programs, and looked ahead to opportunities for this decade. For COVID-19, decades of investments in basic and translational research, new technology platforms, and vaccines targeting prototype pathogens enabled a rapid, global response. Unprecedented global coordination and partnership h...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Andrew Ford Angela Hwang Annie X Mo Shahida Baqar Nancy Touchette Carolyn Deal Deborah King Kristen Earle Birgitte Giersing Peter Dull B Fenton Hall Source Type: research
A novel high throughput plate-based method for 2-PE quantification in novel multidose vaccines (R21 malaria, Covishield and Covovax) and combination vaccines (Hexavalent)
Vaccine. 2023 Feb 17:S0264-410X(23)00174-3. doi: 10.1016/j.vaccine.2023.02.039. Online ahead of print.ABSTRACTMultidose presentation of vaccines is the most preferred choice, for mass immunization particularly during pandemics. WHO also recommends multidose containers of fill finished vaccines for programmatic suitability and global immunizations programmes. However, multidose vaccine presentations requires inclusion of preservatives to prevent contaminations. 2-Phenoxy ethanol (2-PE) is one such preservative which is being used in numerous cosmetics and many vaccines recently. Estimation of 2-PE content in multidose vials...
Source: Vaccine - February 21, 2023 Category: Allergy & Immunology Authors: Dnyanesh Ranade Rajender Jena Kundan Patil Vikas Dogar Shubham Sancheti Vicky Deore Siddharam Ashtagi Sunil Gairola Source Type: research
Structural and genomic analysis of single nucleotide polymorphisms in human host factor endothelial protein C receptor (EPCR) reveals complex interplay with malaria parasites
Infect Genet Evol. 2023 Feb 10:105413. doi: 10.1016/j.meegid.2023.105413. Online ahead of print.ABSTRACTPlasmodium parasites responsible for malaria follow a complex life cycle of which half takes place inside the human host. Parasites present diverse antigens at different stages of their life cycle and interact with many surface molecules to attach to and enter host cells. The CIDRα1 domain of Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) in infected erythrocytes adheres to one such vascular receptor endothelial protein C receptor (EPCR). EPCR is implicated in the pathogenesis of severe malaria as prefere...
Source: Infection, Genetics and Evolution - February 12, 2023 Category: Genetics & Stem Cells Authors: Jasmita Gill Amit Sharma Source Type: research
