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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane
Int J Med Microbiol. 2023 Apr 3;313(3):151579. doi: 10.1016/j.ijmm.2023.151579. Online ahead of print.ABSTRACTPlasmodium falciparum-related malaria represents a serious worldwide public health problem due to its high mortality rates. P. falciparum expresses rhoptry neck protein 4 (PfRON4) in merozoite and sporozoite rhoptries, it participates in tight junction-TJ formation via the AMA-1/RON complex and is refractory to complete genetic deletion. Despite this, which PfRON4 key regions interact with host cells remain unknown; such information would be useful for combating falciparum malaria. Thirty-two RON4 conserved region-...
Source: International Journal of Medical Microbiology - April 8, 2023 Category: Microbiology Authors: Fredy A Pulido-Quevedo Gabriela Ar évalo-Pinzón Jeimmy J Casta ñeda-Ramírez Adriana Barreto-Santamar ía Manuel E Patarroyo Manuel A Patarroyo Source Type: research
Large DNA fragment knock-in and sequential gene editing in Plasmodium falciparum: a preliminary study using suicide-rescue-based CRISPR/Cas9 system
Mol Cell Biochem. 2023 Apr 1:1-9. doi: 10.1007/s11010-023-04711-5. Online ahead of print.ABSTRACTCRISPR/Cas9 technology applied to Plasmodium falciparum offers the potential to greatly improve gene editing, but such expectations including large DNA fragment knock-ins and sequential gene editing have remained unfulfilled. Here, we achieved a major advance in addressing this challenge, especially for creating large DNA fragment knock-ins and sequential editing, by modifying our suicide-rescue-based system that has already been demonstrated to be highly efficient for conventional gene editing. This improved approach was confi...
Source: Molecular and Cellular Biochemistry - April 2, 2023 Category: Biochemistry Authors: Junnan Lu Ying Tong Rui Dong Yijun Yang Wen Hu Minghong Zhang Quan Liu Siting Zhao John H Adams Li Qin Xiaoping Chen Source Type: research
Systematic Review of Safety of RTS,S with AS01 and AS02 Adjuvant Systems Using Data from Randomized Controlled Trials in Infants, Children, and Adults
CONCLUSION: Most of the adverse events observed from RTS,S/AS01 and RTS,S/AS02 malaria vaccines were reported in the control group and shared by other vaccines. Hence, the authors concluded that both RTS,S/AS01 and RTS,S/AS02 malaria vaccines are safe.PMID:36941908 | PMC:PMC10024506 | DOI:10.2147/CPAA.S400155
Source: Clinical Pharmacology: Advances and Applications - March 21, 2023 Category: Allergy & Immunology Authors: Wubetu Yihunie Bekalu Kebede Bantayehu Addis Tegegne Melese Getachew Dehnnet Abebe Yibeltal Aschale Habtamu Belew Bereket Bahiru Source Type: research
