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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Structural and genomic analysis of single nucleotide polymorphisms in human host factor endothelial protein C receptor (EPCR) reveals complex interplay with malaria parasites
Infect Genet Evol. 2023 Feb 10:105413. doi: 10.1016/j.meegid.2023.105413. Online ahead of print.ABSTRACTPlasmodium parasites responsible for malaria follow a complex life cycle of which half takes place inside the human host. Parasites present diverse antigens at different stages of their life cycle and interact with many surface molecules to attach to and enter host cells. The CIDRα1 domain of Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) in infected erythrocytes adheres to one such vascular receptor endothelial protein C receptor (EPCR). EPCR is implicated in the pathogenesis of severe malaria as prefere...
Source: Infection, Genetics and Evolution - February 12, 2023 Category: Genetics & Stem Cells Authors: Jasmita Gill Amit Sharma Source Type: research
IFN γ, TNFα polymorphisms and IFNγ serum levels are associated with the clearance of drug-resistant P. falciparum in Malian children
This study investigates host regulatory cytokines and immunogenomic factors associated with the clearance of Plasmodium falciparum carrying a chloroquine resistance genotype. Biological samples from participants of previous drug efficacy trials conducted in two Malian localities were retrieved. The P. falciparum chloroquine resistance transporter (Pfcrt) gene was genotyped using parasite DNA. Children carrying parasites with the mutant allele (Pfcrt-76T) were classified based on their ability to clear their parasites. The levels of the different cytokines were measured in serum. The polymorphisms of specific human genes in...
Source: Cytokine - February 11, 2023 Category: Molecular Biology Authors: Bourema Kouriba Charles Arama Dinkorma T Ouologuem Yacouba Cissoko Mahamadou Diakite Abdoul Habib Beavogui Mamadou Wele Mamadou Tekete Bakary Fofana Souleymane Dama Hamma Maiga Aminatou Kone Amadou Niangaly Issa Diarra Modibo Daou Ando Guindo Karim Traore Source Type: research
Extracellular Vesicles derived from Plasmodium-infected Hosts as Stimuli of ''Trained'' Innate Immunity
Curr Med Chem. 2023 Feb 7. doi: 10.2174/0929867330666230207115157. Online ahead of print.ABSTRACTAlthough the burden of malaria has been successfully controlled globally, this disease remains a major public health issue. To date, neither existing drugs nor vaccines against malaria are sufficient in eliminating malaria worldwide. To achieve the eradication of malaria by 2040, effective interventions targeting all Plasmodium species are urgently needed. As the cornerstone of vaccine design, immune memory serves a significant role in the host's defense against Plasmodium infections. It has long been considered that innate imm...
Source: Cancer Control - February 7, 2023 Category: Cancer & Oncology Authors: Jin-Guang Chen Yun-Ting Du Chang-Hui Guan Hua-Yu Fan Yang-Ai Liu Ting Wang Xin Li Guang Chen Source Type: research
Prevalence, determinants, and reasons for malaria vaccine hesitancy among caregivers of under-five children in Nigeria: Results from a nationwide cross-sectional survey
CONCLUSION: The findings of this survey provide a valuable blueprint for the development of targeted interventions to facilitate caregiver acceptance of the RTS,S vaccine.PMID:36725434 | DOI:10.1016/j.vaccine.2023.01.060
Source: Vaccine - February 1, 2023 Category: Allergy & Immunology Authors: Sahabi Kabir Sulaiman Fatimah Isma'il Tsiga-Ahmed Muhammad Sale Musa Abdulwahab Kabir Sulaiman Farouq Muhammad Dayyab Moien Ab Khan Saidu Idris Ahmad Udoyen Abasi-Okot Akpan UmmuKulthum Ibrahim Usman Abdulaziz Tjjani Bako Source Type: research
Cost of introducing and delivering RTS,S/AS01 malaria vaccine within the malaria vaccine implementation program
This study estimates the incremental costs of introducing and delivering the malaria vaccine within routine immunization programs in the context of malaria vaccine pilot introduction, to help inform decision-making.METHODS: An activity-based, retrospective costing was conducted from the governments' perspective. Vaccine introduction and delivery costs supported by the donors during the pilot introduction were attributed as costs to the governments under routine implementation. Detailed resource use data were extracted from the pilot program expenditure and activity reports for 2019-2021. Primary data from representative he...
Source: Vaccine - January 29, 2023 Category: Allergy & Immunology Authors: Ranju Baral Ann Levin Chris Odero Clint Pecenka John Tanko Bawa Kwadwo Odei Antwi-Agyei Kwame Amponsa-Achaino Mike Nenani Chisema Rose Eddah Jalango Rouden Mkisi Scott Gordon Winthrop Morgan Farzana Muhib Source Type: research
Assessment of the quality of antenatal care in Mozambique
CONCLUSIONS: In general, the criteria recommended for quality antenatal care are not incorporated into clinical practice in Mozambique.IMPLICATIONS FOR PRACTICE: While quality antenatal care is essential to reduce maternal morbidity and mortality, many sub-Saharan countries still have low-quality antenatal care services, which is one of the reasons why these countries have the highest maternal mortality rates worldwide.PMID:36706649 | DOI:10.1016/j.midw.2023.103598
Source: Midwifery - January 27, 2023 Category: Midwifery Authors: Belarmina Reis-Muleva Ana Luiza Vilela Borges Luciane Sim ões Duarte Carolina Cavalcante da Silva Dos Santos Nat ália de Castro Nascimento Source Type: research
Viruses to rescue health: Vaccination
Med Sci (Paris). 2022 Dec;38(12):1052-1060. doi: 10.1051/medsci/2022168. Epub 2022 Dec 13.ABSTRACTViruses have been used as tools to prevent viral infections themselves for more than two centuries with impressive success. After the empirical discoveries of the first vaccines, today the development of genetic engineering, molecular virology, reverse genetics, the manipulation of viral genomes, their high-throughput sequencing and their chemical synthesis, the mastery of cell culture and purification methods have greatly benefited the development of viral vaccines. Since smallpox and rabies, the history of vaccinology has fo...
Source: Cancer Control - January 24, 2023 Category: Cancer & Oncology Authors: Fr édéric Tangy Jean-Nicolas Tournier Source Type: research
Licensed liposomal vaccines and adjuvants in the antigen delivery system
BioTechnologia (Pozn). 2022 Dec 24;103(4):409-423. doi: 10.5114/bta.2022.120709. eCollection 2022.ABSTRACTLiposomes (LSs) are promising nanoparticles with unique properties such as controlled nanosize, large surface area, increased reactivity, and ability to undergo modification. Worldwide, licensed liposomal forms of antibiotics, hormones, antioxidants, cytostatics, ophthalmic drugs, etc., are available on the pharmaceutical market. This review focuses on the adjuvant properties of LSs in the production of vaccines (VACs). LS-VACs have the following advantages: antigens with low immunogenicity can become highly immunogeni...
Source: Herpes - January 23, 2023 Category: Infectious Diseases Authors: Yuriy Krasnopolsky Daria Pylypenko Source Type: research
