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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Strategies for malaria vaccination during the COVID-19 pandemic in African countries
Bull World Health Organ. 2022 Oct 1;100(10):582-582A. doi: 10.2471/BLT.21.287472.NO ABSTRACTPMID:36188023 | PMC:PMC9511673 | DOI:10.2471/BLT.21.287472
Source: Bulletin of the World Health Organization - October 3, 2022 Category: International Medicine & Public Health Authors: Kapil Narain Sudhan Rackimuthu Faisal A Nawaz Osaretin Christabel Okonji Henry Ashworth Stefan S Du Plessis Jaffer Shah Source Type: research
Population genetic analysis of Plasmodium falciparum cell-traversal protein for ookinetes and sporozoite among malaria patients from southern Nigeria
Infect Genet Evol. 2022 Sep 28:105369. doi: 10.1016/j.meegid.2022.105369. Online ahead of print.ABSTRACTPlasmodium falciparum immune escape mechanisms affect antigens being prioritized for vaccine design. As a result of the multiple surface antigens the parasite exhibits at different life cycle stages, designing a vaccine that would efficiently boost the immune system in clearing infections has been challenging. The P. falciparum cell-traversal protein for ookinetes and sporozoite (Pfceltos) is instrumental for ookinete traversal of the mosquito midgut and sporozoites invasion of the human liver cells. Pfceltos elicits bot...
Source: Infection, Genetics and Evolution - October 1, 2022 Category: Genetics & Stem Cells Authors: Mary A Oboh Clement Isaac Marissa N Schroeter Olanrewaju B Morenikeji Alfred Amambua-Ngwa Martin M Meremikwu Bolaji N Thomas Source Type: research
Housebreaking Plasmodium parasites leave their fingerprints at the door
Trends Parasitol. 2022 Sep 23:S1471-4922(22)00209-4. doi: 10.1016/j.pt.2022.09.005. Online ahead of print.ABSTRACTProtective antibodies against Plasmodium falciparum merozoite antigens, including EBA-175, can inhibit erythrocyte invasion. New data from Musasia et al. indicate that these antibodies can also trigger antibody-dependent phagocytosis of ring-infected and uninfected erythrocytes and that this correlates with protection from malaria. This provides a new pathway for vaccine design.PMID:36163104 | DOI:10.1016/j.pt.2022.09.005
Source: Trends in Parasitology - September 26, 2022 Category: Parasitology Authors: Lara Bardtke Ian A Cockburn Source Type: research
Deceiving and escaping complement - the evasive journey of the malaria parasite
Trends Parasitol. 2022 Sep 8:S1471-4922(22)00190-8. doi: 10.1016/j.pt.2022.08.013. Online ahead of print.ABSTRACTDuring its life cycle, Plasmodium, the malaria parasite, is exposed to the human and mosquito complement systems. Early experiments demonstrated that activation of complement can pose a serious threat to parasites, but recent studies revealed complement-evasion mechanisms important for parasite survival. Blood-stage parasites and gametes recruit regulators to neutralize human complement activation, while ookinetes inhibit mosquito complement by disrupting epithelial nitration in response to midgut invasion. Here...
Source: Trends in Parasitology - September 11, 2022 Category: Parasitology Authors: Maartje R Inklaar Carolina Barillas-Mury Matthijs M Jore Source Type: research
