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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Effects of public health emergencies of international concern on disease control: a systematic review
CONCLUSIONS: Socioeconomic inequity is a determinant of the effects of public health emergencies of international concern within affected populations. The diversion of resources and attention from health authorities disproportionately affects vulnerable populations and can lead, over time, to a weakening of health systems. The analysis of the effects of public health emergencies is important for the development of new protocols that can better respond to future crises.PMID:37089787 | PMC:PMC10120386 | DOI:10.26633/RPSP.2023.74
Source: Pan American Journal of Public Health - April 21, 2023 Category: International Medicine & Public Health Authors: Giovanna Rotondo de Ara újo Pedro A S V de Castro Isabela R Ávila Juliana Maria T Bezerra David S Barbosa Source Type: research
A sting in the tail-are antibodies against the C-terminus of Plasmodium falciparum circumsporozoite protein protective?
EMBO Mol Med. 2023 Apr 21:e17556. doi: 10.15252/emmm.202317556. Online ahead of print.ABSTRACTMalaria remains a huge burden on global public health. Annually there are more than 200 million cases with > 600,000 deaths worldwide, the vast majority of which occur within Sub-Saharan Africa (WHO; World Malaria Report, 2021). Malaria disease is the consequence of infection by a protozoan parasite from the genus Plasmodium with most morbidity and mortality caused by P. falciparum. With rates of infection plateauing and rebounding in some areas (in particular, as a result of the disruption caused by the COVID-19 pandemic), the...
Source: Molecular Medicine - April 21, 2023 Category: Molecular Biology Authors: Jem Murdoch Jake Baum Source Type: research
Molecular and functional properties of human Plasmodium falciparum CSP C-terminus antibodies
EMBO Mol Med. 2023 Apr 21:e17454. doi: 10.15252/emmm.202317454. Online ahead of print.ABSTRACTHuman monoclonal antibodies (mAbs) against the central repeat and junction domain of Plasmodium falciparum circumsporozoite protein (PfCSP) have been studied extensively to guide malaria vaccine design compared to antibodies against the PfCSP C terminus. Here, we describe the molecular characteristics and protective potential of 73 germline and mutated human mAbs against the highly immunogenic PfCSP C-terminal domain. Two mAbs recognized linear epitopes in the C-terminal linker with sequence similarity to repeat and junction motif...
Source: Molecular Medicine - April 21, 2023 Category: Molecular Biology Authors: Opeyemi Ernest Oludada Giulia Costa Clare Burn Aschner Anna S Obraztsova Katherine Prieto Caterina Canetta Stephen L Hoffman Peter G Kremsner Benjamin Mordm üller Rajagopal Murugan Jean-Philippe Julien Elena A Levashina Hedda Wardemann Source Type: research
Modelling the relative cost-effectiveness of the RTS,S/AS01 malaria vaccine compared to investment in vector control or chemoprophylaxis
CONCLUSIONS: Use of RTS,S results in reductions in malaria cases and deaths even when layered upon existing interventions. When comparing relative cost-effectiveness, scale up of ITNs, introduction of SMC, and switching to new technology nets should be prioritized in eligible settings.PMID:37080831 | DOI:10.1016/j.vaccine.2023.04.011
Source: Vaccine - April 18, 2023 Category: Allergy & Immunology Authors: Hillary M Topazian Nora Schmit Ines Gerard-Ursin Giovanni D Charles Hayley Thompson Azra C Ghani Peter Winskill Source Type: research
Plasmodium falciparum rhoptry neck protein 4 has conserved regions mediating interactions with receptors on human erythrocytes and hepatocyte membrane
Int J Med Microbiol. 2023 Apr 3;313(3):151579. doi: 10.1016/j.ijmm.2023.151579. Online ahead of print.ABSTRACTPlasmodium falciparum-related malaria represents a serious worldwide public health problem due to its high mortality rates. P. falciparum expresses rhoptry neck protein 4 (PfRON4) in merozoite and sporozoite rhoptries, it participates in tight junction-TJ formation via the AMA-1/RON complex and is refractory to complete genetic deletion. Despite this, which PfRON4 key regions interact with host cells remain unknown; such information would be useful for combating falciparum malaria. Thirty-two RON4 conserved region-...
Source: International Journal of Medical Microbiology - April 8, 2023 Category: Microbiology Authors: Fredy A Pulido-Quevedo Gabriela Ar évalo-Pinzón Jeimmy J Casta ñeda-Ramírez Adriana Barreto-Santamar ía Manuel E Patarroyo Manuel A Patarroyo Source Type: research
