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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults
Am J Trop Med Hyg. 2023 May 9:tpmd220773. doi: 10.4269/ajtmh.22-0773. Online ahead of print.ABSTRACTThe radiation-attenuated Plasmodium falciparum sporozoites (PfSPZ) Vaccine has demonstrated safety and immunogenicity in 5-month-old to 50-year-old Africans in multiple trials. Except for one, each trial has restricted enrollment to either infants and children or adults < 50 years old. This trial was conducted in Equatorial Guinea and assessed the safety, tolerability, and immunogenicity of three direct venous inoculations of 1.8 × 106 or 2.7 × 106 PfSPZ, of PfSPZ Vaccine, or normal saline administered at 8-week interva...
Source: The American Journal of Tropical Medicine and Hygiene - May 9, 2023 Category: Tropical Medicine Authors: Said A Jongo Vicente Urbano Nsue Ndong Nchama L W Preston Church Ally Olotu Stephen R Manock Tobias Schindler Ali Mtoro Natasha Kc Orrin Devinsky Elcin Zan Ali Hamad Elizabeth Nyakarungu Maxmillian Mpina Anna Deal Jos é Raso Bijeri Martin Eka Ondo Mangue Source Type: research
Biological activity of 1,2,3-triazole-2-amino-1,4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control
Eur J Med Chem. 2023 Apr 18;255:115400. doi: 10.1016/j.ejmech.2023.115400. Online ahead of print.ABSTRACTMalaria can be caused by several Plasmodium species and the development of an effective vaccine is challenging. Currently, the most effective tool to control the disease is the administration of specific chemotherapy; however, resistance to the frontline antimalarials is one of the major problems in malaria control and thus the development of new drugs becomes urgent. The study presented here sought to evaluate the antimalarial activities of compounds derived from 2-amino-1,4-naphthoquinones containing 1,2,3-triazole us...
Source: European Journal of Medicinal Chemistry - May 2, 2023 Category: Chemistry Authors: Renata Maria Costa Souza Lilian Maria Lapa Montenegro Pimentel Laryssa Kathleen Mendon ça Ferreira Val éria Rêgo Alves Pereira Aline Caroline Da Silva Santos Willyenne Mar ília Dantas Carla Jasmine Oliveira Silva Ramayana Morais De Medeiros Brito Jos Source Type: research
Extending the range of Plasmodium falciparum transmission blocking antibodies
Vaccine. 2023 Apr 24:S0264-410X(23)00453-X. doi: 10.1016/j.vaccine.2023.04.042. Online ahead of print.ABSTRACTRecent work demonstrating that asymptomatic carriers of P. falciparum parasites make up a large part of the infectious reservoir highlights the need for an effective malaria vaccine. Given the historical challenges of vaccine development, multiple parasite stages have been targeted, including the sexual stages required for transmission. Using flow cytometry to efficiently screen for P. falciparum gamete/zygote surface reactivity, we identified 82 antibodies that bound live P. falciparum gametes/zygotes. Ten antibod...
Source: Vaccine - April 26, 2023 Category: Allergy & Immunology Authors: Lacy M Simons Patricia Ferrer Nita Gombakomba Knashka Underwood Raul Herrera David L Narum Gaspar Canepa Festus Acquah Linda Amoah Patrick E Duffy Carolina Barillas-Mury Carole Long Shwu-Maan Lee Emily Locke Kazutoyo Miura Kim C Williamson Source Type: research
Effects of public health emergencies of international concern on disease control: a systematic review
CONCLUSIONS: Socioeconomic inequity is a determinant of the effects of public health emergencies of international concern within affected populations. The diversion of resources and attention from health authorities disproportionately affects vulnerable populations and can lead, over time, to a weakening of health systems. The analysis of the effects of public health emergencies is important for the development of new protocols that can better respond to future crises.PMID:37089787 | PMC:PMC10120386 | DOI:10.26633/RPSP.2023.74
Source: Pan American Journal of Public Health - April 24, 2023 Category: International Medicine & Public Health Authors: Giovanna Rotondo de Ara újo Pedro A S V de Castro Isabela R Ávila Juliana Maria T Bezerra David S Barbosa Source Type: research
A sting in the tail-are antibodies against the C-terminus of Plasmodium falciparum circumsporozoite protein protective?
EMBO Mol Med. 2023 Apr 21:e17556. doi: 10.15252/emmm.202317556. Online ahead of print.ABSTRACTMalaria remains a huge burden on global public health. Annually there are more than 200 million cases with > 600,000 deaths worldwide, the vast majority of which occur within Sub-Saharan Africa (WHO; World Malaria Report, 2021). Malaria disease is the consequence of infection by a protozoan parasite from the genus Plasmodium with most morbidity and mortality caused by P. falciparum. With rates of infection plateauing and rebounding in some areas (in particular, as a result of the disruption caused by the COVID-19 pandemic), the...
Source: Molecular Medicine - April 21, 2023 Category: Molecular Biology Authors: Jem Murdoch Jake Baum Source Type: research
